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Jalen Hurts #1 of the Philadelphia Eagles rushes the ball against the San Francisco 49ers at Lincoln Financial Field on Sept. 19, 2021.
Jalen Hurts #1 of the Philadelphia Eagles rushes the ball against the San Francisco 49ers at Lincoln Financial Field on Sept. 19, 2021. Tim Nwachukwu/Getty Images/AFP

The San Francisco 49ers head on the road to face the Philadelphia Eagles in the NFC Championship game after winning 12 straight games. Here are our best 49ers vs. Eagles NFL picks based on the best NFL odds.

The 49ers haven’t lost since Oct. 23, and quarterback Brock Purdy has never lost an NFL game as a starting quarterback. After surviving the Divisional Round with a 19-12 win over the Dallas Cowboys, the 49ers are 2.5-point underdogs as they take on the NFC’s top seed.

Get more action on the NFC Championship with our 49ers vs. Eagles player prop picks and 49ers vs. Eagles SGP picks, as well as our Jalen Hurts player props and Christian McCaffrey player props.

Including the postseason, the Eagles are 15-1 in games started by quarterback Jalen Hurts this season. They have won those 15 games by an average of 12.7 points per contest. They are averaging 28.6 points per game, the second-most in the NFL, and allowing 19.6 per contest, the sixth-fewest in the league.

Check out below for our best 49ers vs. Eagles pick for the NFC Championship game (odds via Caesars Sportsbook; pick confidence based on a 1-to-5-star scale), then check out our 49ers vs. Eagles player prop picks.

Check out our Bengals vs. Chiefs picks and NFL best bets for the Conference Championships.

49ers vs. Eagles game info

Date: Sunday, Jan. 29, 3 p.m.
Location: Lincoln Financial Field, Philadelphia, PA
Weather: 50 degrees, 8-mph winds, 59% chance of precipitation

Looking to get an early start on The Big Game? Check out our break down of the hypothetical Super Bowl odds and lines ahead of Championship Weekend, as well as our 2023 Super Bowl odds.

49ers vs. Eagles odds

49ers vs. Eagles odds analysis

With just hours remaining before kickoff, the Eagles are now trading at -3 at Caesars, after spending much of the week at -2.5 with increased juice on their side of the spread. Are other sportsbooks likely to follow suit or are they more comfortable keeping the line at Eagles -2.5 with increased juice? 

As for the total, the number opened at 45, and despite 60% of bets on the Under, it has gone up to as high as 45.5 at all of the major sportsbooks. We’ve seen this type of movement often this postseason, such as last weekend when the Cincinnati Bengals were a popular pick, but the spread kept growing in favor of the Buffalo Bills. Ultimately, the public was right.

Check out our Super Bowl odds and Super Bowl MVP odds.

49ers vs. Eagles pick

Eagles -2.5 (-115 via Caesars Sportsbook) vs. 49ers ⭐⭐⭐

This is a tough game to pick whether looking at player props, the spread, or the total. The 49ers are the hottest team in football, and they have the best-scoring defense in the league. They have allowed just two teams to score 30 or more against them this year. That’s been a recipe for success, as they’re averaging 26.8 points per game, tied for fourth most in the NFL, and they have scored more than 30 in four of their last five games.

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Yet, the Eagles’ numbers are just as impressive. Despite being without Hurts for two games at the end of the season, the Eagles still averaged the second-most points in the league, and their defense has been one of the most underrated units in all of football this season. We’ve seen both of these teams win by scoring in the 20s, but we’ve also seen them win shootouts. Therefore, it’s hard to know exactly what kind of game we’re going to get on Sunday.

However, we’re taking the Eagles for two reasons. First, they have been fantastic at home this season. They're 8-2 and though their only loss with Hurts under center did come at Lincoln Financial Field, they outscored their opponents by an average of 12.5 points in their home victories. Five of their 10 home games were against playoff teams. Second, they have Hurts who has been the most dynamic player in the NFL all season.

The 49ers are allowing just 79 yards rushing per game, which makes it hard to trust Hurts’ prop, but if he can add to his 794 rushing yards, it could take the 49ers out of their game plan. This is a tough game to pick, but the Eagles have the slight edge and should probably be favored by more than three.

Check out our Jalen Hurts player prop bets and Christian McCaffrey player prop bets.

49ers vs. Eagles best odds

Caesars (-115)

Eagles -2.5Eagles -2.5Eagles -2.5Eagles -2.5Eagles -2.5

The five major sportsbooks are all in agreement on the line for this game, but DraftKings is offering a slightly inflated price for the Eagles. Therefore, if you're on the 49ers, the best place to bet is DraftKings, but if you are on the Eagles, any of the other four major sportsbooks are fine to bet at. 

Interestingly, DraftKings is offering the best Eagles’ moneyline, so if you’re looking to parlay their outright win with other props, then DraftKings is the best place to do so. And finally, Caesars is offering the lowest total, so if you like the Eagles and the Over, then Caesars is the place to go.

49ers vs. Eagles pick made 01/27/2023 at 8:49 a.m. ET.

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