Oklahoma vs. Iowa Prediction, Odds & Preview: Best Picks for Women's March Madness

Last Updated: March 24, 2025 9:24 AM EDT • 6 minute read X Social Google News Link

The No. 3 seed Oklahoma Sooners (26-7) meet the No. 6 seed Iowa Hawkeyes (23-10) in the women's NCAA Tournament second round today at 4 p.m. ET (ESPN) at Lloyd Noble Center in Norman, Okla.
The Sooners are 4.5-point betting favorites to advance in the Spokane 4 Region of the women's March Madness bracket. We dive into whether the Hawkeyes have a chance for the upset in our Oklahoma vs. Iowa prediction, odds and preview as part of our women's March Madness predictions.
🏀 Oklahoma vs. Iowa prediction & picks for Monday
Here are my best Oklahoma vs. Iowa predictions for the second round of the NCAA Tournament; use our parlay calculator to get the best odds for any same-game parlay:
✅ Against the spread pick: Oklahoma -4.5 (-110 via BetMGM) vs. Iowa ⭐⭐⭐⭐
🔥 Best player prop bet: Payton Verhulst 4+ 3-pointers made (+205 via FanDuel) ⭐⭐⭐
🎯 Exact score prediction: Oklahoma 92, Iowa 83 (OFF)
👉 Want more picks? Check out our latest college basketball picks and the rest of our March Madness second-round predictions.
🏆 Best Oklahoma vs. Iowa pick, player prop bet & score prediction
Our NEW college basketball player prop odds tool can help you find the best odds for any March Madness market across legal sportsbooks in your area!
✅ Oklahoma to cover the spread: -4.5 ⭐⭐⭐⭐
In the first round of the NCAA Tournament, the Hawkeyes had no trouble slowing down the third-highest-scoring offense in the nation.
The Murray State Racers ended the season averaging 86.8 points per game, but the Hawkeyes held them to just 57. Today, the Hawkeyes’ defense will be tested against another great offense, as the Sooners are averaging 85.1 points per game, fifth-best in the nation.

Unlike Saturday, the Hawkeyes’ defense is going to struggle. The Sooners have been one of the best offensive teams all season, scoring at will against some of the best teams in the nation, such as Alabama, Tennessee, and LSU.
The Hawkeyes rank 45th in the country, averaging 74.8 points per game. Yet, while the Sooners rank 278th in scoring defense, they’ve held three of their last four opponents to 65 or fewer points. After a straightforward win in the first round, the Hawkeyes’ offense won’t be able to keep pace with the Sooners, as the Hawkeyes lose a very high-scoring game.
📊 Best odds: -110 via BetMGM ($10 to win $9.09)
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🔥 Payton Verhulst 4+ 3-pointers made ⭐⭐⭐
Verhulst was just 1-for-5 from long-range in her first game of the tournament, managing 13 points in 34 minutes. She’s now made three or fewer 3-pointers in four consecutive games. Despite that, I expect Verhulst to light it up tonight against the Hawkeyes.
Verhulst is the Sooners’ second-leading-scorer, averaging 14.9 points per game. She also leads the team in 3-pointers, knocking down 77 for the season. Her average from beyond the arc sits at an impressive 34.8%.
Verhulst has made at least four 3-pointers in eight games this season, so this is a risk. However, the price for this prop considers that risk. You could take her to make more than 2.5 shots from beyond the arc, but the price is -128. That’s a steep price considering Verhulst hasn’t shot the ball well in recent games.
Still, I expect this game to be so high-scoring that I am happy to take her to make more shots than she usually does for great odds.
📊 Best odds: +205 via FanDuel ($10 to win $20.50)
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🎯 Score prediction: Oklahoma 92, Iowa 83
The Sooners scored 81 points in their first game of the tournament. In a much more competitive game, they should top their season average and get into the 90s for the first time since March 2. After all, this team scored at least 90 in 10 games this season.
The Hawkeyes’ offense is good enough to keep pace for most of the game, but the Sooners will ultimately hit more shots to secure the win. Though the spread for this game isn’t huge, exact score props are currently unavailable. However, based on recent evidence, I expect a price of +19000 or +20000 when it goes live.
📊 Best odds: OFF
🤖 Oklahoma vs. Iowa AI prediction
For entertainment purposes, we asked ChatGPT to analyze historical trends and live NCAA Tournament stats before predicting the winner and exact score for Oklahoma vs. Iowa. Our AI prediction projects a final score of Iowa 86, Oklahoma 78.
🖥️ AI score prediction: Iowa 86, Oklahoma 78
- Oklahoma is one of the highest-scoring teams in the country, averaging over 80 points per game. The Sooners’ offense is highly effective, thanks to their fast-paced play, three-point shooting, and offensive versatility.
- Both teams have shown they can struggle defensively against high-powered offenses.
- Iowa is a solid rebounding team. The Hawkeyes are not as dominant on the boards as other top teams, but they are good enough to compete with most opponents.
🤔 Betting takeaway: ChatGPT's AI prediction would mean Iowa covering the spread (+4.5) and a total of Over 155.5 points. ChatGPT is not a dedicated sports betting model, but it can identify data that March Madness bettors might overlook.
📊 Live Oklahoma vs. Iowa odds
Follow the latest live March Madness college basketball odds and real-time NCAA Tournament scores for the second round.
🔢 Oklahoma vs. Iowa opening odds
- Spread: Oklahoma -4.5 (-110) | Iowa +4.5 (-110)
- Moneyline: Oklahoma -192 | Iowa +160
- Over/Under: Over 158.5 (-110) | Under 158.5 (-110)
📺 How to watch Oklahoma vs. Iowa: NCAA Tournament second round
📅 Date: Monday, March 24
🕗 Time: 4 p.m. ET
📍 Location: Lloyd Noble Center (Norman, Okla.)
📺 TV: ESPN
💻 Streaming: March Madness Live
💰 March Madness betting odds pages
March Madness odds | March Madness MVP odds |
Women's March Madness odds | March Madness MVP predictions |
Final Four odds | March Madness prop bets |
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