March Madness Predictions Today: Expert Picks & Scores for Every NCAA Tournament Game

Last updated: March 23, 2025 9:23 AM EDT β’ 5 min read X Social Google News Link

After an exciting first day in the second round of the NCAA Tournament featured wildly competitive contests, our March Madness predictions today expect even more upheaval, with the first game of the remaining Round of 32 slate tipping off at 12:10 p.m. ET.
π Can't get enough March Madness action? Check out the rest of our March Madness second-round expert picks as part of our March Madness predictions.
π° March Madness predictions, NCAA Tournament odds & expert picks today
π Sunday's March Madness odds & schedule
π No. 3 Kentucky vs. No. 6 Illinois, 5:15 p.m. ET (CBS), Midwest Region
β
ATS prediction: Illinois -1.5 (-110 via Caesars) vs. Kentucky ββββ
π― Score prediction: Illinois 87, Kentucky 84 (+17000 via DraftKings)
Here's why Brenden Schaeffer is picking Illinois to cover the spread (-1.5):
"We like the Illini to neutralize Kentuckyβs strength from behind the arc, as Illinois ranks third in the nation in limiting opposing 3-point percentage. With both teams trotting out elite offenses, weβre siding with Illinois, which holds the clear edge on defense (29th in effective field-goal percentage defensively, compared to 143rd for Kentucky)."
π For more analysis, check out our Kentucky vs. Illinois prediction.
π Kentucky vs. Illinois odds
π No. 2 Alabama vs. No. 7 Saint Mary's, 6:10 p.m. ET (TNT), East Region
β
ATS prediction: Alabama -5.5 (-110 via BetMGM) vs. St. Maryβs ββββ
π― Score prediction: Alabama 82, Saint Maryβs 73 (+19000 via DraftKings)
Here's why Phil Wood is picking Alabama to cover the spread (-5.5):
"This spread feels like a massive overreaction to how the Crimson Tide played in the first round. They beat the Auburn Tigers and Kentucky Wildcats right before the tournament, so writing Alabama off after sleepwalking against an inferior opponent seems unwise."
π For more analysis, check out our Alabama vs. Saint Mary's prediction.
π Alabama vs. Saint Mary's odds
π No. 4 Maryland vs. No. 12 Colorado State, 7:10 p.m. ET (TBS), West Region
β
ATS prediction: Maryland -7 (-110 via Caesars) vs. Colorado State ββββ
π― Score prediction: Maryland 77, Colorado State 66 (+14000 via DraftKings)
Here's why Isaiah Sirois is picking Maryland to cover the spread (-7):
"The advanced stats paint a rosy picture of Maryland. Since Feb. 1, the Terps rank sixth in T-Rank, led by their first-ranked defense. Maryland is 15th in 3-point percentage allowed through that stretch at 28.3%. Colorado State is a solid 19th in T-Rank, but its offense has depended upon the unit's third-ranked 3-point percentage (43%)."
π For more analysis, check out our Maryland vs. Colorado State prediction.
π Maryland vs. Colorado State odds
π No. 3 Iowa State vs. No. 6 Ole Miss, 7:45 p.m. ET (truTV), South Region
β
ATS prediction: Ole Miss +5.5 (-110 via BetMGM) vs. Iowa State ββββ
π― Score prediction: Iowa State 79, Ole Miss 77 (+19000 via DraftKings)
Here's why Phil Wood is picking Ole Miss to cover the spread (+5.5):
"The Cyclones were essentially perfect in their first game. However, Iβm not putting much stock in that blowout. The Cyclones didn't feel the absence of Keshon Gilbert much in the first round. But that will change now, as the battle-tested Rebels should keep this close and potentially pull off the upset."
π For more analysis, check out our Iowa State vs. Ole Miss prediction.
π Iowa State vs. Ole Miss odds
π No. 2 Michigan State vs. No. 10 New Mexico, 8:40 p.m. ET (TNT), South Region
β
ATS prediction: New Mexico +7.5 (-110 via FanDuel) vs. Michigan State βββ
π― Score prediction: Michigan State 74, New Mexico 70 (+18000 via DraftKings)
Here's why Mike Spector is picking New Mexico to cover the spread (+7.5):
"While Michigan State uses its tempo as an advantage over most teams, Richard Pitinoβs bunch will not be fazed, as it plays at the sixth-fastest tempo in the country. With this Spartans team ranking outside the top 300 in 3-point shooting, I'm taking the Lobos to cover."
π For more analysis, check out our Michigan State vs. New Mexico prediction.
π Michigan State vs. New Mexico odds
π No. 4 Arizona vs. No. 5 Oregon, 9:40 p.m. ET (TBS), East Region
β
ATS prediction: Oregon +4 (-110 via bet365) vs. Arizona βββ
π― Score prediction: Arizona 76, Oregon 75 (+17000 via DraftKings)
Here's why Mike Spector is picking Oregon to cover the spread (+4):
"The Ducks possess much more size this season with 7-foot Nate Bittle healthy (he was limited to six games last season) to compete with Arizonaβs frontcourt. Oregonβs only loss since Feb. 8 is to Michigan State, and the Ducks should be well rested for this matchup, with no player playing more than 27 minutes in Fridayβs rout of Liberty."
π For more analysis, check out our Arizona vs. Oregon prediction.
π Arizona vs. Oregon odds
π Best March Madness odds, predictions & expert picks today
Here are our best March Madness picks for Sunday's second-round action:
- March Madness odds & schedule today
- March Madness survivor pool picks today
- March Madness predictions today
- Best March Madness player props today
- March Madness upset picks today
π° March Madness betting odds pages
March Madness odds | March Madness MVP odds |
Women's March Madness odds | March Madness MVP predictions |
Final Four odds | March Madness prop bets |
π Best March Madness betting sites
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