Best March Madness Sweet 16 Parlay: Best Moneyline Picks Today With +1615 Odds

Favorites have dominated the NCAA Tournament so far, but our best March Madness Sweet 16 parlay bets feature two underdogs with a shot at cashing in tonight.

We've combined our expert picks for every Sweet 16 game today into a four-leg parlay with +1615 odds, which would turn a $10 bet into a $161.50 profit if we hit on our four moneyline picks for tonight's games.

👉 Can't get enough March Madness action? Check out the latest March Madness Sweet 16 odds & full schedule and the rest of our March Madness predictions.  

💰 Our best March Madness parlay bets today for the NCAA Tournament

Here are the best odds for our March Madness Sweet 16 parlay using our NEW parlay calculator to instantly determine the best price across our best sports betting sites.

🔥 BYU (+190) vs. Alabama
🔥 Maryland (+230) vs. Florida
🔥 Duke (-556) vs. Arizona
🔥 Texas Tech (-233) vs. Arkansas

🚀 Best parlay odds: +1615 via ESPN BET ($10 to win $161.50)

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🔮 March Madness score predictions & Sweet 16 moneyline odds tonight

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🏀 Alabama vs. BYU prediction, 7:09 p.m. ET (CBS), East Region

🎯 Score prediction: BYU 94, Alabama 90
💰 Best Alabama moneyline odds: +190 via bet365

Here's why Mike Spector is picking BYU to win outright:

"Alabama plays one of the most unique styles of any D-I college basketball team, blending an up-tempo attack with elite spacing and shooting and getting almost all of its shots from 3-point range or at the rim. While many teams struggle with dealing with the Crimson Tide’s modernized philosophies, that plays right into BYU’s hands. The Cougars are arguably the closest mirror image of Alabama as any team in the country."

👉 For more analysis & latest odds, check out our Alabama vs. BYU prediction.

📊 Alabama vs. BYU odds

🏀 Florida vs. Maryland prediction, 7:39 p.m. ET (TBS/truTV), West Region

🎯 Score prediction: Maryland 76, Florida 74
💰 Best Maryland moneyline odds: +230 via bet365

Here's why Isaiah Sirois is picking Maryland to win outright:

"While I respect the incredible offensive output from Florida, both teams have been playing slower. The other key part of the equation is that Maryland’s defense matches well against the Gators. The Gators rank 37th in 3-point rate since the start of February, so if Maryland can continue to play strong perimeter defense, the favorites won’t have such an easy time winning this game."

👉 For more analysis & latest odds, check out our Florida vs. Maryland prediction.

📊 Florida vs. Maryland odds

🏀 Duke vs. Arizona prediction, 9:39 p.m. ET (CBS), East Region

🎯 Score prediction: Duke 80, Arizona 75
💰 Best Duke moneyline odds: -480 via FanDuel

Here's why Mike Spector is picking Duke to win outright:

"Though the Blue Devils and Wildcats combined to score just 124 points in their Nov. 22 meeting, I expect both offenses to have more success and play with more fluidity with 36 games apiece under their belts. That’s why I’m predicting a final score of Duke 80, Arizona 75."

👉 For more analysis & latest odds, check out our Duke vs. Arizona prediction.

📊 Duke vs. Arizona odds

🏀 Texas Tech vs. Arkansas prediction, 10:09 p.m. ET (TBS/truTV), West Region

🎯 Score prediction: Texas Tech 80, Arkansas 70
💰 Best Texas Tech moneyline odds: -233 via ESPN BET

Here's why Isaiah Sirois is picking Texas Tech to win outright:

"The stats don’t support a bet on Arkansas here. Since Feb. 1, Texas Tech ranks a nice eighth in T-Rank led by its seventh-best offense. Arkansas ranks 24th, with its 16th-ranked defense leading the way. Texas Tech runs a balanced offense, ranking 10th in turnover rate over that sample, with the defense a steady 42nd."

👉 For more analysis & latest odds, check out our Texas Tech vs. Arkansas prediction.

📊 Texas Tech vs. Arkansas odds

🏀 Best March Madness odds, predictions & expert picks today

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🗓️ Sweet 16 schedule & TV info today

• No. 2 Alabama vs. No. 6 BYU, 7:09 p.m. ET (CBS), East Region
• No. 1 Florida vs. No. 4 Maryland, 7:39 p.m. ET (TBS/truTV), West Region
• No. 1 Duke vs. No. 4 Arizona, 9:39 p.m. ET (CBS), East Region
• No. 3 Texas Tech No. 10 Arkansas, 10:09 p.m. ET (TBS/truTV), West Region

💰 March Madness betting odds pages

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