Yankees vs. Twins Prediction, Odds & Expert Picks: MLB Best Bets for Sept. 15

We're targeting New York -1.5 and Carlos Rodon Under 6.5 strikeouts in our Yankees vs. Twins prediction.
Yankees vs. Twins Prediction, Odds & Expert Picks: MLB Best Bets for Sept. 15
Pictured: New York Yankees right fielder Aaron Judge (99) high-fives designated hitter Giancarlo Stanton (27) after hitting a solo home run. Photo by Brian Fluharty via Imagn Images.

The New York Yankees take on a reeling Minnesota Twins team, and I’m expecting them to add to the misery as I make my Yankees vs. Twins prediction. First pitch for the series opener is set for 7:40 p.m. ET on Monday evening from Target Field in Minneapolis.

My MLB picks like New York to cover as a 1.5-run favorite, while starting pitcher Carlos Rodon stays Under his strikeouts prop.

Meanwhile, our Mike Spector has Jazz Chisholm Jr. as his featured pick for his best home run predictions today.


⚾ Yankees vs. Twins expert picks & predictions

MLB odds subject to change.

  • Moneyline pick: Yankees (-185 via bet365) ⭐⭐
  • Run line pick: Yankees -1.5 (-110 via bet365) ⭐⭐⭐⭐
  • Over/Under pick: Over 8.5 (-115 via Caesars) ⭐⭐⭐

📝 Yankees vs. Twins preview & best bet

Track the latest MLB scores for line movement and matchup info.

🔥 Yankees -1.5 (-110) ⭐⭐⭐⭐

Yankees vs. Twins Prediction, Odds & Expert Picks: MLB Best Bets for Sept. 15
Pictured: New York Yankees first baseman Ben Rice (22) hits an RBI single. Photo by Paul Rutherford via Imagn Images.

The Yankees have historically enjoyed seeing the Twins on the schedule. New York has only lost a season series against Minnesota once since 2001 and is 8-1 vs. the Twins since the start of the 2024 campaign.

The Twins are 24th in team ERA (4.61) this season and also rank below league average in home runs allowed. That is a potential recipe for disaster against a Yankees lineup that leads MLB in home runs, runs scored, and OPS this season. The Twins are 3-10 in September with a 6.24 ERA, which is 29th in the league. 

Twins starting pitcher Simeon Woods Richardson has yet to face the Yankees in his career but has struggled to the tune of a 4.94 ERA over his last seven starts. This has all the makings of an eruption spot for the Yankees. 

One of the best sports betting sites, bet365, offered -110 odds on the Yankees -1.5, which nets out a profit of $9.09 on a $10 bet. The -110 odds have an implied probability of 52.38%.


💰 Best Yankees vs. Twins player prop bet

Our MLB player prop odds tool shows the best odds for every market across legal sportsbooks in your area.

⬇️ Carlos Rodon Under 6.5 strikeouts ⭐⭐⭐

Yankees vs. Twins Prediction, Odds & Expert Picks: MLB Best Bets for Sept. 15
Pictured: New York Yankees starting pitcher Carlos Rodon (55) delivers a pitch. Photo by Vincent Carchietta via Imagn Images.

This line feels a little lofty when considering Carlos Rodon's recent run on the mound. The All-Star left-hander has a solid 3.18 ERA since the All-Star break but only 51 strikeouts across 56 2/3 innings over that span.

He hasn’t fanned more than six batters in a start since Aug. 1. In fact, Rodon has only cleared six strikeouts in two of his last 11 starts. The Twins are right around league average in strikeout rate and have been performing relatively well at the plate so far in September.

Rodon did have success against Minnesota in his last outing, allowing just one run and one hit over seven strong innings. However, he struck out only five batters with a pair of walks in New York’s 9-1 victory. I think Rodon can have success with a similar blueprint to his last appearance against the Twins.

A $10 wager on Rodon’s Under pays out a profit of $8.33 at DraftKings. The -120 odds have an implied probability of 54.55%.


📊 Yankees vs. Twins odds: Sept. 15

MLB odds update live in real time.

📈 Yankees vs. Twins betting odds analysis

New York opened as high as a -200 favorite, with some of the best sports betting apps offering the Yankees as low as -178.


🔢 Yankees vs. Twins stats

Season stats courtesy of baseball-reference.com.

Yankees (83-66) Statistic (per game) Twins (65-84)
5.20 Runs 4.24
8.45 Hits 8.05
.249 AVG .239
.454 SLG .399
.783 OPS .712
4.00 ERA 4.61
8.98 K/9 8.59
3.52 BB/9 2.02
1.10 HR/9 1.24

🚑 Yankees vs. Twins injuries


📺 Yankees vs. Twins game info

  • When: Monday, Sept. 15
  • First pitch: 7:40 p.m. ET
  • Where: Target Field (Minneapolis)
  • How to watch: Local TV

💡 Expert MLB predictions today


❓ Yankees vs. Twins FAQs

Who is favored to win Yankees vs. Twins?

The Yankees are a -185 favorite to defeat the Twins on the road on Monday.

What is the run line for Yankees vs. Twins?

New York is a -1.5 run line favorite against Minnesota in Monday’s matchup.

What is the Over/Under for Yankees vs. Twins?

The total for Monday’s game between the Yankees and Twins is 7.5.

What are the best bets for Yankees vs. Twins?

My best bets for Monday’s Yankees vs. Twins game are New York -1.5 and Carlos Rodon Under 6.5 strikeouts (-120). 

When is the Yankees vs. Twins game?

First pitch is set for 7:40 p.m. ET on Monday.

How do baseball odds work?

When betting on MLB, the run line shows how many runs the favorite needs to win by in order to cash the bet. For example, a favorite of -1.5 must win by two or more runs to cover the run line, while an underdog at +1.5 must win outright or lose by one run to cover the run line.

Moneyline odds represent the payout for picking the outright winner (+200 means a $100 bet wins $200, while -200 means a $200 bet wins $100). Over/Unders let you wager on whether the combined total of runs will be higher or lower than the set number.

You can determine the payouts and implied probabilities for any wager - or convert odds to different formats - with our odds converter.

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