Cubs vs. Cardinals Prediction, Odds & Best Bets: Arenado, Cardinals to Get Best of Cubs

The Cardinals have teed off against Jameson Taillon over the course of his career, and I see it happening again tonight.
Cubs vs. Cardinals Prediction and Odds
Pictured: Nolan Arenado - who's highlighted in our Cubs vs Cardinals prediction - celebrates with teammates in the dugout after hitting a solo home run. Photo by Kamil Krzaczynski-Imagn Images.

The Chicago Cubs look to bounce back at Busch Stadium against the St. Louis Cardinals after four home runs ultimately did them in last night. Jameson Taillon is on the mound against Michael McGreevy at 7:45 p.m. ET, but where are we headed with our best Cubs vs. Cardinals prediction? Let's answer that very question and win some money while doing so.

  • Cubs vs. Cardinals prediction: Cardinals to win (-102 via FanDuel) ⭐⭐⭐⭐⭐
  • Over/Under prediction: Over 9 runs (-105 via BetMGM) ⭐⭐⭐⭐
  • Best player prop pick: Nolan Arenado Over 1.5 bases (+140 via FanDuel) ⭐⭐⭐⭐⭐

⚾ Cubs vs. Cardinals predictions & odds tonight

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💰 Cubs vs. Cardinals prediction & best bet

✅ Best bet: St. Louis Cardinals moneyline (-102 via FanDuel)

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Make no mistake - this will be a high-scoring affair between these two teams, and while I love the Over 9 runs at -105 betting odds, I think the best Cubs vs Cardinals prediction and value lies with St. Louis (-102 betting odds) on the moneyline.

If you know me, you know I love a large sample size, and that's exactly what we have with Taillon on the mound against the Cardinals - St. Louis just has his number, and that won't stop today at home.

Over 130 plate appearances, the Cards are hitting a scorching .315 against the right-hander, highlighted by Nolan Arenado (11-for-25) and Alec Burleson (6-for-15, 2 2B, 2 HR). Look for the ball to be in play a ton against Taillon, who's striking this team out at just a 16% rate.

Chicago and St. Louis are also some of the best Over teams in baseball, hitting at 56%. Be prepared for some runs, with the Cardinals coming out on top in the end.

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