Cubs vs. Cardinals Prediction, Odds & Best Bets: Arenado, Cardinals to Get Best of Cubs

Last Updated: June 24, 2025 1:26 PM EDT • 3 minute read X Social Google News Link

The Chicago Cubs look to bounce back at Busch Stadium against the St. Louis Cardinals after four home runs ultimately did them in last night. Jameson Taillon is on the mound against Michael McGreevy at 7:45 p.m. ET, but where are we headed with our best Cubs vs. Cardinals prediction? Let's answer that very question and win some money while doing so.
- Cubs vs. Cardinals prediction: Cardinals to win (-102 via FanDuel) ⭐⭐⭐⭐⭐
- Over/Under prediction: Over 9 runs (-105 via BetMGM) ⭐⭐⭐⭐
- Best player prop pick: Nolan Arenado Over 1.5 bases (+140 via FanDuel) ⭐⭐⭐⭐⭐
⚾ Cubs vs. Cardinals predictions & odds tonight
🔎 Our NEW MLB player prop odds tool can help you find the best MLB odds to make your best MLB picks.
📊 Live Cubs vs. Cardinals odds
💰 Cubs vs. Cardinals prediction & best bet
✅ Best bet: St. Louis Cardinals moneyline (-102 via FanDuel)
Each product featured on our website has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.
Make no mistake - this will be a high-scoring affair between these two teams, and while I love the Over 9 runs at -105 betting odds, I think the best Cubs vs Cardinals prediction and value lies with St. Louis (-102 betting odds) on the moneyline.
If you know me, you know I love a large sample size, and that's exactly what we have with Taillon on the mound against the Cardinals - St. Louis just has his number, and that won't stop today at home.
Over 130 plate appearances, the Cards are hitting a scorching .315 against the right-hander, highlighted by Nolan Arenado (11-for-25) and Alec Burleson (6-for-15, 2 2B, 2 HR). Look for the ball to be in play a ton against Taillon, who's striking this team out at just a 16% rate.
Chicago and St. Louis are also some of the best Over teams in baseball, hitting at 56%. Be prepared for some runs, with the Cardinals coming out on top in the end.
💡 More MLB predictions today
- Best NRFI bets today
- MLB home run predictions
- Athletics vs. Tigers prediction
- Braves vs. Mets prediction
- Yankees vs. Reds prediction
- Chase Burns player prop bets
- Cubs vs. Cardinals prediction
- Phillies vs. Astros prediction
💵 Best MLB betting sites
Want to bet on Cubs vs. Cardinals? Check out the best MLB betting sites and best sportsbook promos for today's MLB games:
- FanDuel Promo Code | Read our FanDuel Review
- DraftKings Promo Code | Read our DraftKings Review
- Hard Rock Bet Promo Code | Read our Hard Rock Bet Review
(21+. Gambling Problem? Call 1-800-GAMBLER)
* Bonuses not applicable in Ontario.
Not intended for use in MA.
Each betting site featured on SBR has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.

Dustin Saracini X social