Yankees vs. Reds Prediction, Odds & Best Bets Tonight: Will New York Spoil Chase Burns' Debut?

It's probably not the ideal situation for a debut, as we offer our prediction for the Reds' highly Chase Burns against the Bronx Bombers.

C Jackson Cowart

Last Updated: June 24, 2025 4:32 PM EDT • 3 minute read

Yankees vs. Reds Prediction, Odds & Best Bets Tonight — Pictured: New York Yankees outfielder Aaron Judge prepares on deck. Photo by Katie Stratman via Imagn Images

Talk about a baptism of fire for Chase Burns, who makes his Cincinnati Reds (41-38) debut tonight when they face the New York Yankees at Great American Ball Park (7:10 p.m. ET).

Our Yankees vs. Reds prediction, odds, and best bets expect Burns to struggle against the Bronx Bombers, the betting favorites across our best sports betting sites.

The Yankees are favored between -160 and -165, with an Over/Under of 9 runs.

Yankees vs. Reds prediction: Yankees -1.5 (+100 via BetMGM) ⭐⭐⭐⭐
Over/Under prediction: Over 9.5 (-105 via BetMGM) ⭐⭐⭐
Best player prop pick: Chase Burns Over 2.5 earned runs allowed (-113 via Caesars) ⭐⭐⭐⭐

⚾ Yankees vs. Reds predictions & odds

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🧢 Yankees vs. Reds starting pitchers

Yankees: Carlos Rodon (9-5, 3.11 ERA)
Reds: Chase Burns (MLB debut)

💰 Yankees vs. Reds prediction & best bet

✅ Best bet: Chase Burns Over 2.5 earned runs allowed (-113 via Caesars)

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It's finally Chase Burns day for Reds fans, which comes less than a year after Cincinnati took him second overall in the rookie draft. While he dominated the lower levels across just 66 innings, I'm skeptical he'll flash that same form against arguably MLB's best lineup.

While the Dodgers boast more raw star power, the Yankees lead MLB in wOBACON (.403) and average exit velocity (90.7 MPH) while ranking second in barrel rate (11.1%). Translation? They're crushing baseballs across the yard, and I don't expect that to change at the third-best park for hitters.

If you think New York chases Burns before the fifth inning, DraftKings is offering +115 odds on a short outing for the rookie (Under 14.5 outs). I suspect he'll get a longer leash to showcase his dominant stuff during Burns' debut, but I'd be shocked if he isn't tagged for a few runs along the way.

🔢 Yankees vs. Reds updated betting insights

Updated betting info via BetMGM.

The Yankees opened at -160 moneyline favorites. Those odds haven't changed
The total, which hasn't changed, is at nine runs, juiced at -110 on both sides

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Written by:
C Jackson Cowart

C Jackson Cowart is a publishing editor and lead writer for Sportsbook Review. An award-winning writer, reporter, and editor with a decade of sports media experience, "C-Jax" has worked with ESPN, Forbes, theScore, and various daily newspapers before joining the Sportsbook Review team. He's a proud graduate of the University of North Carolina, where he served as a beat writer for the Tar Heels' championship run through the NCAA men's basketball tournament in 2017. Jackson has spent the last five years covering sports betting as a predictive analyst, features writer, and industry reporter. Since joining the team in 2023, he's played a key role in Sportsbook Review's coverage of the Super Bowl, March Madness, and NBA playoffs while serving as the lead writer for the growing WNBA and NASCAR betting scenes. Though he's cashed some big bets over the years -- including Lamar Jackson to win MVP (twice) -- he's still haunted by enough second-place bet slips to wallpaper his home office. While Jackson is a committed "process over results" bettor with a keen eye for advanced stats and subtle bias in futures markets, he also embraces sports betting as a vehicle for entertainment and personal investment. He's written about everything from hot dogs to groundhogs and still hasn't forgiven his "inside source" for a sabotaged bet on the Gatorade color in Super Bowl LV.