Best Home Run Predictions Today: MLB Odds, Picks & Prop Bets for Sept. 15

Our best home run predictions today are eyeing Jazz Chisholm Jr., Alejandro Kirk, Shohei Ohtani, and Matt Olson.

Mike Spector

Last Updated: September 15, 2025 9:38 AM EDT • 4 minute read

Pictured: New York Yankees second baseman Jazz Chisholm Jr. celebrates as we look at our best home run predictions today. Photo by Wendell Cruz / Imagn.

Though there are just nine games on Monday’s MLB slate, four of the league's top six home run hitters are in action, which means there should be plenty of value for my best home run predictions today.

My MLB picks are centered around New York Yankees slugger Jazz Chisholm Jr., who etched his name among several of the franchise’s greats over the weekend. My best home run bets today also take fliers on Alejandro Kirk, Shohei Ohtani, and Matt Olson for potential juicy payouts.

A $10 parlay on all four sluggers going yard would pay out over $4,400 in profit if they each hit a four-bagger.

💰 MLB best home run predictions & odds today: Sept. 15

Here are my best MLB home run predictions and odds today, with my pick confidence based on a 1-to-5-star scale. You can also check out our MLB player prop odds tool for the latest MLB odds at the best legal sportsbooks in your region.

🧨 Matt Olson to hit a home run (+360 via FanDuel) ⭐⭐⭐
🧨 Alejandro Kirk to hit a home run (+520 via FanDuel) ⭐⭐
🧨 Jazz Chisholm Jr. to hit a home run (+340 via DraftKings) ⭐⭐⭐⭐
🧨 Shohei Ohtani to hit a home run (+310 via FanDuel) ⭐⭐⭐

💣 Best home run prediction today: MLB expert picks & prop bets

Here is my favorite MLB home run bet today and analysis of why it leads my MLB home run predictions.

💣 Best home run prediction today: MLB expert picks & prop bets

Here are my best home run bets today. Check out the rest of our MLB picks along with our guide on how to bet on MLB.

⚾ Jazz Chisholm Jr. (Yankees) to hit a home run ⭐⭐⭐

Chisholm hit his 40th home run as a Yankee over the weekend and 29th this season. He's now one home run shy of his first career campaign with 30 round-trippers and 30 stolen bases, and the infielder has already set a career-high with 75 RBI.

Chisholm is one of seven Yankees to hit 40-plus home runs within their first 162 games with the franchise. He now faces Minnesota Twins righty Simeon Woods Richardson, who has allowed at least one home run in five of his last six starts, and seven total dingers during that span.

Woods Richardson has given up four long balls in his last 13 2/3 innings, making Chisholm’s 22.73% implied probability to homer a great value play based on DraftKings’ +340 odds. That's where I'm heading for the best payout, as a $10 winning wager would net $34 in profit.

Our Josh Goldberg also breaks down the full Monday night matchup in his Yankees vs. Twins prediction.

📊 Yankees vs. Twins odds

🚀 Best home run parlay picks

Here is our best MLB home run parlay for Monday's baseball action; use our parlay calculator to get the best odds for any parlay.

💣 Matt Olson to hit a home run (+360 via FanDuel)
💣 Alejandro Kirk to hit a home run (+520 via FanDuel)
💣 Jazz Chisholm Jr. to hit a home run (+340 via FanDuel)
💣 Shohei Ohtani to hit a home run (+255 via FanDuel)

Parlay odds: +44448 via FanDuel ($10 to win $4,444.82)

💡 Expert MLB predictions today

❓ Best home run predictions FAQs

What are the best home run props for tonight?

My best home run predictions today feature Jazz Chisholm Jr., Alejandro Kirk, Shohei Ohtani, and Matt Olson.

What is a home run bet?

A home run bet is a wager on a hitter to hit a HR at any point during a game. Some sportsbooks allow you to bet on a hitter to not hit a home run, but the most common bet is on them to do so.

Can you parlay home run bets?

Yes, you can parlay home run bets. We've provided our best home run parlay today.

How do I place a home run bet?

To place a home run bet, simply go to your favorite sportsbook and go to the game featuring the player of your choice. Then click on batter props and you should see an option to bet a player to hit a home run.

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Written by:
Mike Spector

Mike started in the sports writing industry in July 2019, and gained a lot of followers in his first year after finishing with the No. 2 overall record in an annual NFL betting competition, which made picks against the spread, and from an Over/Under and moneyline perspective. Mike is an avid fan of the NFL, MLB, tennis, and all college sports. In his opinion, March Madness is the best sporting event there is, and he's especially euphoric starting with conference tournament time in college basketball. Mike's a big advocate of "fading the public" and making plays that are contrarian, constantly citing that "there are reasons why they have those big shiny buildings in Las Vegas." When making wagers, Mike leans on his NFL experience and always scours the best odds at all of the major sports betting sites, where he mostly sifts through DraftKings, FanDuel, BetMGM, and bet365. He's tried several others and is of the firm belief that bettors should not just stick to one sportsbook, as there is always likely better value to be had with the same wager. In addition, while Mike received his undergraduate degree from Villanova University, he has no issue betting against the Wildcats when it comes to college basketball wagering, and suggests other bettors should always put their “head” before their “hearts.”