College Football Week 6 Expert Picks

Our Sportsbook Review analysts have thoughtfully selected a collection of expert college football picks for Week 6 matchups, utilizing the finest NCAAF odds from our best sports betting apps. This page serves as your comprehensive resource, featuring our top Saturday selections.

We have already reached the midway point of the college football regular season, and Week 6 will provide crucial insights into the direction of this season. The rivalry showdown between Texas and Oklahoma could determine the front-runner for the Big 12 championship, while Alabama faces an important litmus test against Texas A&M.

Our college football experts have put together a list of their favorite picks on many of the top games this weekend. For even more bets, check out college football Week 6 player props, college football Week 6 predictions, and college football Week 6 upset picks.

Here are our best college football bets for Week 6 (odds via our best college football betting sites; pick confidence based on a 1-to-5-star scale).

College football Top 25 schedule

(Odds via FanDuel)

• No. 23 LSU (-4.5) at No. 22 Missouri
• Maryland at No. 4 Ohio State (-19.5)
• No. 12 Oklahoma at No. 3 Texas (-6.5)
• No. 13 Washington State at UCLA (-3.5)
• No. 11 Alabama (-1.5) at Texas A&M
• Syracuse at No. 14 North Carolina (-9.5)
• Virginia Tech at No. 5 Florida State (-23.5)
• No. 20 Kentucky at No. 1 Georgia (-14.5)
• No. 2 Michigan (-19.5) at Minnesota
• No. 10 Notre Dame (-6.5) at No. 25 Louisville
• Arizona at No. 9 USC (-21.5)

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College football Week 6 expert picks

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College football Week 6 top picks

Daniel Hishaw Jr. Over 0.5 rushing touchdowns (+145 via DraftKings) ⭐⭐⭐⭐⭐

Hishaw has -110 (or worse) anytime touchdown odds across the board at our best sports betting apps, which is why we are taking advantage of the +145 value by shopping at DraftKings. Hishaw has to score a rushing touchdown to cash this ticket, but that shouldn’t be a problem for the backup Kansas running back.

Devin Neal, who is the starting tailback for KU, is more of the pass-catching threat out of the backfield. Hishaw hasn’t recorded a single catch this season, but he has scored three times in four games as the red-zone and short-yardage back. Dating back to last year, Hishaw has 10 touchdowns in nine games for the Jayhawks. He also scored one of the two touchdowns against Texas last weekend.

With starting quarterback Jalon Daniels sidelined for the second week in a row, we expect Kansas to lean on the ground game against UCF. That’s great news for Hishaw and Co. in a game that has a total above 60.

–– Shane Jackson (SBR | Twitter/X)

Wake Forest team total Under 16.5 (-125 via bet365) ⭐⭐⭐⭐⭐

Clemson’s defense should put the clamps on the Wake Forest offense this week. The Tigers are playing at home in Death Valley this week while facing a Demon Deacons offense that really wishes Sam Hartman hadn’t transferred to Notre Dame.

Wake ranks 115th in adjusted offensive efficiency on the season. In its most recent game, a home contest in Week 4, this group mustered just 16 points against a Georgia Tech defense that ranks 104th in the country in adjusted defensive efficiency. Aside from that effort, GT has allowed 41.6 points per game to FBS opponents this year — failing to reach 20 against this unit is a huge indictment on Wake Forest.

Clemson, meanwhile, boasts the fourth-best adjusted defensive efficiency in the country. The Tigers rank 25th nationally in opponent rushing yards per game and should be able to stifle that element of the Wake offense. FanDuel lists Wake’s point total at 14.5 with -110 odds on Under. We’re angling for the bet365 offering as Wake Forest scoring three field goals and a touchdown would still cash that Under.

–– Brenden Schaeffer (SBR | Twitter/X)

K.J. Jefferson Over 1.5 passing touchdowns (+105 via DraftKings) ⭐⭐⭐⭐

Razorbacks quarterback K.J. Jefferson had the highest QBR last year of all SEC quarterbacks who returned this season. Thus, we are treating his 9-for-17 performance, in which he totaled a 20.7 QBR, as a one-off, and we expect him to fill up the box score given how many opportunities he will get against Ole Miss.

The Rebels play lightning-fast, averaging a play quicker than every 22 seconds, so Jefferson and the Razorbacks offense should possess the ball plenty. Jefferson has multiple passing touchdowns in three of five games this season, and in the two where he threw just one touchdown, his team averaged 26.5 points in those games. 

Ole Miss allowed LSU’s Jayden Daniels to throw for 414 yards and four touchdowns last week, and its secondary now has a coverage grade rank of 92nd among FBS teams. Considering Jefferson is averaging better than 10 yards per attempt and has a PFF passing grade of 86.5, he should have success against the Rebels. 

The same +105 odds can be found at DraftKings and bet365, while FanDuel offers worse value with -130 odds to back Jefferson to throw two-plus touchdowns.

–– Mike Spector (SBR | Twitter/X)

UCLA -3 (-115 via bet365) ⭐⭐⭐⭐

This spread makes absolutely no sense at first glance. The Cougars are 4-0, they’re ranked 13th in the country, and they’re averaging 533.8 yards per game. Meanwhile, the Bruins are 3-1, and they scored just seven points their last time out against the Utah Utes.

Both teams are coming off a bye, but the timing of that week off was much more beneficial for the Bruins than the Cougars. The Cougars offense was clicking, and they just posted a huge win over the Oregon State Beavers. For the Bruins, the bye week was about fixing an offense that looked horrible last time out.

Even after that bad performance, the Bruins are averaging 456 yards per game, and they’re about to face a defense that has allowed 21 points in every game this season. Finally, it’s worth noting that the Bruins opened as 2.5-point favorites, and despite 60% of wagers backing the Cougars, this spread has moved to 3, and even 3.5, at some of the major sportsbooks.

–– Phil Wood (SBR | Twitter/X)

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