Big Ten Predictions, Odds & Best Bets Week 4

There are 12 games featuring Big Ten teams this weekend, including a showdown between two College Football Playoff odds contenders as USC makes its conference debut against Michigan.

The Wolverines host the Trojans in a marquee conference matchup, as we make the best Big Ten predictions for Week 4.

Despite opening as a college football championship odds favorite, Michigan has struggled offensively this season. Will its defense shut down the Trojans’ offense and give the team a chance to win?

In other action, Minnesota hosts Iowa in a matchup between two defensive-minded teams.

And in Chestnut Hill, Michigan State is a 6.5-point underdog at our college football betting sites against Boston College. Our Week 4 college football predictions detail why the Eagles are on upset alert.

Big Ten best bets: Week 4

College football odds as of Friday and subject to change. Track the college football scores for the latest line movement and matchup info.

• USC -4.5 (-110 via FanDuel) vs. Michigan ⭐⭐⭐⭐
• Iowa vs. Minnesota Under 35.5 (-105 via BetMGM) ⭐⭐⭐⭐
• Michigan State ML (+205 via bet365) vs. Boston College  ⭐⭐⭐

Best Big Ten predictions this week

College football picks made Friday; odds subject to change. Our NEW college football player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

USC -4.5 (-110) ⭐⭐⭐⭐

The Wolverines were blown out at home by Texas in Week 2, and they once again find themselves as home underdogs.

Alex Orji is getting his first start after Davis Warren threw six interceptions in the first three weeks of the season. But even with Orji under center, this is still an offense that only managed 28 points against Arkansas State.

Meanwhile, Miller Moss has completed 72.7% of his passes this season, and the Trojans’ offense is clicking. This offense is too good for the Wolverines and 17 points may be all they need to cover. 

FanDuel and DraftKings are the only sportsbooks with this spread under five points. FanDuel is offering a slightly better price, with a $10 winning bet paying a $9.09 profit.

Best odds: -110 via FanDuel | Implied probability: 52.38%

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Iowa vs. Minnesota Under 35.5 (-105) ⭐⭐⭐⭐

The Over has hit in all three of the Hawkeyes’ games this season. Last week, the offense put up 38 points, while the defense allowed 21. The defensive performance was a little concerning, but oddsmakers still have this number set incredibly low.

A big reason why this total is still so low is the defensive play of the Golden Gophers. They have shut out back-to-back teams.

Both of these teams has played one game against Power 4 conference teams, and the totals for those two contests were 39 and 36.

With non-conference play over, look for a typical Big Ten matchup between two teams that play a lot of defense, but struggle a lot on offense. If the Under hits, a $10 bet pays a $9.52 profit.

Best odds: -105 via BetMGM | Implied probability: 51.22%

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Michigan State ML (+205) ⭐⭐⭐

There is something so fishy about this game and the spread available at each of the five major sportsbooks. The Eagles are coming off a 27-21 road loss to No. 7 Missouri. And yet, they’re only favored by 6.5 in this game.

I recommend taking the Spartans against the spread to hedge, but the moneyline offers true value. This is a letdown spot for the Eagles after their near upset last week.

Meanwhile, the Spartans are coming off a 40-0 win over Prairie View A&M. Michigan State ranks 51st in passing yards per game and the Eagles are 96th in passing yards allowed. 

Aidan Chiles needs to take care of the football, but even if he turns it over once, the Spartans’ defense will do enough in this game to thwart a hungover Eagles’ offense. If they sneak away with a big win, a $10 bet pays a $20.50 profit.

Best odds: +205 via bet365 | Implied probability: 32.79%

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More Big Ten predictions for Week 4

• Illinois vs. Nebraska prediction
• Illinois vs. Nebraska player props
• UCLA vs. LSU prediction
• USC vs. Michigan prediction
• USC vs. Michigan player props

College football betting odds pages

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• bet365 Bonus Code: SBRBONUS | Read our bet365 Review
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• DraftKings Promo Code | Read our DraftKings Review

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