NFL Week 5 Predictions: Picks & Odds for Marquee Games
The Super Bowl odds continue to move every week, and the 14-game Week 5 slate features several highly impactful matchups.
We'll round up our betting experts' NFL Week 5 predictions throughout the week as we look to get the best of the odds from our best NFL betting sites.
The Kansas City Chiefs remain undefeated and the Super Bowl favorites. The Baltimore Ravens climbed the rankings with Sunday night's statement beatdown of the Buffalo Bills. And the Minnesota Vikings are the most surprising 4-0 team as we prepare to cross over the quarter-pole of the season.
All three are favorites by the NFL Week 5 odds.
NFL picks & predictions Week 5
Our NEW NFL player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!
- Jets vs. Vikings early picks (London)
- Jets vs. Vikings prediction
- Jets vs. Vikings player prop bets
- Aaron Rodgers player prop bets
- Justin Jefferson touchdown picks
- Ravens vs. Bengals player prop bets
- Ja'Marr Chase touchown picks
- Jayden Daniels player prop bets
- Bills vs. Texans player prop bets
- Cowboys vs. Steelers early picks (SNF)
- Cowboys vs. Steelers prediction
- Cowboys vs. Steelers SNF player prop bets
- Cowboys vs. Steelers SNF parlay
- Dak Prescott SNF player prop bets
- Justin Fields SNF player prop bets
- First touchdown scorer predictions for SNF
- Saints vs. Chiefs early picks (MNF)
- Saints vs. Chiefs prediction
- Saints vs. Chiefs MNF player prop bets
Don't miss the rest of our Week 5 NFL picks. Listed odds for all games via bet365 unless stated otherwise.
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NFL odds for Sunday
Jets vs. Vikings odds
Prediction: Vikings -2.5 (-110 via BetMGM) vs. Jets ⭐⭐⭐
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Pick made by Mike Spector.
- When: Sunday, Oct. 6 - 9:30 a.m. ET
- Where: Tottenham Hotspur Stadium, London
- How to watch: NFL Network
- Moneyline: Jets +120 | Vikings -140
- Spread: Jets +2.5 (-110) | Vikings -2.5 (-110)
- Total: 40.5 (-110/-110)
Dolphins vs. Patriots odds
- When: Sunday, Oct. 6 - 1 p.m. ET
- Where: Gillette Stadium, Foxborough, Mass.
- How to watch: FOX
- Moneyline: Dolphins -120 | Patriots +100
- Spread: Dolphins -1 (-110) | Patriots +1 (-110)
- Total: 36.5 (-110/-110)
Ravens vs. Bengals odds
Prediction: Lamar Jackson Over 199.5 passing yards (-110 via DraftKings) ⭐⭐⭐⭐
Terms and conditions apply.
Pick made by Andrew Brennan.
- When: Sunday, Oct. 6 - 1 p.m. ET
- Where: Paycor Stadium, Cincinnati
- How to watch: CBS
- Moneyline: Ravens -150 | Bengals +125
- Spread: Ravens -2.5 (-110) | Bengals +2.5 (-110)
- Total: 51 (-110/-110)
Bills vs. Texans odds
Prediction: Cam Akers Over 51.5 rushing yards (-110 via bet365) ⭐⭐⭐⭐
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Pick made by Philip Wood.
- When: Sunday, Oct. 6 - 1 p.m. ET
- Where: NRG Stadium, Houston
- How to watch: CBS
- Moneyline: Bills -105 | Texans -115
- Spread: Bills +1 (-110) | Texans -1 (-110)
- Total: 46.5 (-110/-110)
Browns vs. Commanders odds
Prediction: Jayden Daniels longest completion Under 34.5 Yards (-115 via BetMGM) ⭐⭐⭐⭐
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Pick made by Connor Cooper.
- When: Sunday, Oct. 6 - 1 p.m. ET
- Where: Northwest Stadium, Landover, Md.
- How to watch: FOX
- Moneyline: Browns +145 | Commanders -170
- Spread: Browns +3 (+100) | Commanders -3 (-120)
- Total: 44 (-110/-110)
Colts vs. Jaguars odds
- When: Sunday, Oct. 6 - 1 p.m. ET
- Where: EverBank Stadium, Jacksonville
- How to watch: CBS
- Moneyline: Colts +125 | Jaguars -150
- Spread: Colts +2.5 (+100) | Jaguars -2.5 (-120)
- Total: 46 (-110/-110)
Panthers vs. Bears odds
- When: Sunday, Oct. 6 - 1 p.m. ET
- Where: Soldier Field, Chicago
- How to watch: FOX
- Moneyline: Panthers +160 | Bears -190
- Spread: Panthers +4 (-110) | Bears -4 (-110)
- Total: 42.5 (-110/-110)
Raiders vs. Broncos odds
- When: Sunday, Oct. 6 - 4:05 p.m. ET
- Where: Empower Field at Mile High, Denver
- How to watch: FOX
- Moneyline: Raiders +125 | Broncos -150
- Spread: Raiders +2.5 (+100) | Broncos -2.5 (-120)
- Total: 36.5 (-110/-110)
Cardinals vs. 49ers odds
- When: Sunday, Oct. 6 - 4:05 p.m. ET
- Where: Levi's Stadium, Santa Clara, Calif.
- How to watch: FOX
- Moneyline: Cardinals +275 | 49ers -350
- Spread: Cardinals +7.5 (-110) | 49ers -7.5 (-110)
- Total: 50.5 (-110/-110)
Giants vs. Seahawks odds
- When: Sunday, Oct. 6 - 4:25 p.m. ET
- Where: Lumen Field, Seattle
- How to watch: CBS
- Moneyline: Giants +220 | Seahawks -270
- Spread: Giants +6 (-110) | Seahawks -6 (-110)
- Total: 42 (-110/-110)
Packers vs. Rams odds
- When: Sunday, Oct. 6 - 4:25 p.m. ET
- Where: SoFi Stadium, Inglewood, Calif.
- How to watch: CBS
- Moneyline: Packers -190 | Rams +160
- Spread: Packers -3.5 (-110) | Rams +3.5 (-110)
- Total: 48 (-110/-110)
Cowboys vs. Steelers odds
Prediction: Cowboys +2.5 (-105 via DraftKings) vs. Steelers ⭐⭐⭐
Terms and conditions apply.
Pick made by Mike Spector.
- When: Sunday, Oct. 6 - 8:20 p.m. ET
- Where: Acrisure Stadium, Pittsburgh
- How to watch: NBC/Peacock
- Moneyline: Cowboys +120 | Steelers -140
- Spread: Cowboys +2.5 (-110) | Steelers -2.5 (-110)
- Total: 43 (-110/-110)
NFL odds for Monday
Saints vs. Chiefs odds
- When: Monday, Oct. 7 - 8:15 p.m. ET
- Where: GEHA Field at Arrowfield Stadium, Kansas City
- How to watch: ESPN
- Moneyline: Saints +200 | Chiefs -245
- Spread: Saints +5.5 (-110) | Chiefs -5.5 (-110)
- Total: 42.5 (-110/-110)
NFL picks roundup: Week 5
- NFL survivor picks
- NFL Week 5 against the spread
- NFL upset picks Week 5
- NFL predictions & best bets Week 5
- Anytime touchdown scorer predictions
- Touchdown parlay Week 5
- NFL player props Week 5
NFL betting odds pages
Here are our best NFL betting sites:
- Caesars Promo Code: SBRBONUS1000 | Read our Caesars Review
- BetMGM Bonus Code: SBRBONUS | Read our BetMGM Review
- bet365 Bonus Code: SBRBONUS | Read our bet365 Review
- FanDuel Promo Code | Read our FanDuel Review
- DraftKings Promo Code | Read our DraftKings Review
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Related pages
- Best Sports Betting Sites | Best Sportsbook Promos (U.S. only)
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