NFL Odds & Week 18 Schedule | Betting Lines, Spreads and Totals for Every Game

We look at the NFL odds and Week 18 lines & spreads, focusing on the biggest line movements and playoff implications for the season's final week.
San Francisco 49ers wide receiver Jauan Jennings runs to score a touchdown as we look at the Week 18 NFL odds
Pictured: San Francisco 49ers wide receiver Jauan Jennings runs to score a touchdown as we look at the Week 18 NFL odds. Photo by Kyle Terada-Imagn Images.
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NFL odds Week 18, 2025

The NFL odds for Week 18 are via bet365.

Game Spread  Moneyline Over/Under
Panthers vs. Buccaneers (Saturday) Buccaneers -2.5 CAR +125 / TB -150 44
Seahawks vs. 49ers (Saturday) 49ers +1.5 SEA -120 / SF +100 48
Browns vs. Bengals Bengals -7.5 CLE +290 / CIN -370 44.5
Cowboys vs. Giants Giants +3.5 DAL -205 / NYG +170 51.5
Packers vs. Vikings Vikings -7 GB +275 / MIN -350 35.5
Colts vs. Texans Texans -10 IND +425 / HOU -575 39
Saints vs. Falcons Falcons -3 NO +150 / ATL -180 45
Titans vs. Jaguars Jaguars -12.5 TEN +500 / JAX -700 47.5
Cardinals vs. Rams Rams -7 ARI +260 / LAR -320 46.5
Lions vs. Bears Bears -3 DET +140 / CHI -165 50.5
Chiefs vs. Raiders Raiders +5.5 KC -275 / LV +225 36.5
Chargers vs. Broncos Broncos -12.5 LAC +550 / DEN -800 37.5
Dolphins vs. Patriots Patriots -10.5 MIA +425 / NE -575 45.5
Jets vs. Bills Bills -7 NYJ +280 / BUF -360 38
Commanders vs. Eagles Eagles -4 WSH +165 / PHI -200 39
Ravens vs. Steelers (SNF) Steelers +3.5 BAL -190 / PIT +160 40.5

Our NFL picks will be locked and loaded for Week 18 as we get ready for the season's final week.

  • We have two games on Saturday with division titles on the line:
    • The Bucs are a 2.5-point betting favorite over the visiting Panthers in a battle for the NFC South (Raymond James Stadium, 4:30 p.m. ET, ABC/ESPN)
    • The 49ers are a 1.5-point betting underdog against the visiting Seahawks to claim the NFC West and top seed in the conference (Levi's Stadium, 8 p.m. ET, ABC/ESPN)
  • Sunday's action wraps with the Ravens a 3.5-point road betting favorite over the Pittsburgh Steelers per the Sunday Night Football odds (Acrisure Stadium, 8:20 p.m. ET, NBC/Peacock)

🏈 AFC Seeding Scenarios and Playoff Picture

  • No. 1: Denver Broncos (13-3) -> Denver has clinched the AFC West, and a win will clinch the top seed in the AFC
  • No. 2: New England Patriots (13-3) -> New England has clinched the AFC East, and a win combined with a Denver loss would clinch the top seed in the AFC
  • No. 3: Jacksonville Jaguars (12-4) -> The Jags need one more win to lock up the AFC South; a win combined with Denver and New England losses would clinch the top seed
  • No. 4: Pittsburgh Steelers (9-7) -> The Steelers will clash with the Ravens in Week 18, to the winner goes the AFC North; a loss is playoff elimination
  • No. 5: Houston Texans (11-5) -> The Texans are the top wild card, but could grab the AFC South with a win over the Colts combined with a Jaguars loss
  • No. 6: Los Angeles Chargers (11-5) -> The Bolts are clinched to the postseason but can't claim in the AFC West and will go in as a wild-card team
  • No. 7: Buffalo Bills (11-5) -> The Bills will go in as the third wild-card team due to tiebreakers
  • No. 9 Baltimore Ravens (8-8) -> They might be ninth in the standings, but a victory over Pittsburgh on SNFL will propel them to the AFC North crown and a playoff berth

🏈 NFC Seeding Scenarios and Playoff Picture

  • No. 1: Seattle Seahawks (13-3) -> Seattle will claim the NFC West crown and the top seed with a victory over the 49ers in Week 18
  • No. 2: Chicago Bears (11-5) -> Chicago claimed the NFC North crown last week, but can't move to the top seed and could fall to third if they lose to Detroit and Philadelphia wins
  • No. 3: Philadelphia Eagles (11-5) -> Philadelphia could jump to second if it beats Washington and Chicago loses
    • The Eagles are reportedly resting their starters in Week 18, resulting in the spread moving from -7 to -4
  • No. 4: Carolina Panthers (8-8) -> Carolina faces Tampa Bay in the final week for a chance to claim the NFC South with a win or tie
  • No. 5: San Francisco 49ers (12-4) -> A win over Seattle in the final week would push them to the conferences top seed, a loss and they could fall to sixth
  • No. 6: Los Angeles Rams (11-5) -> The NFC West is out of reach, but the fifth seed could be theirs if they beat Arizona and the 49ers lose
  • No. 7: Green Bay Packers (9-6-1) -> The Pack are locked in as the number seven seed
  • No. 11: Tampa Bay Buccaneers (7-9) -> The Bucs can get in with a victory over the Panthers if Atlanta loses to New Orleans, if Atlanta and Tampa win, all three teams finish 8-9, and Carolina gets in

💡 Draft pick ramifications

  • No. 1: Las Vegas Raiders (2-14)
    • The Raiders enter on a 10 game skid and a 5.5-point underdog against the visiting Chiefs
  • No. 2: New York Giants (3-13)
    • The Giants won last week, but are a 3.5-point underdog against the visiting Cowboys
  • No. 3: New York Jets (3-13)
    • The Jets have dropped four straight and are a 7-point underdog against the Bills
  • No. 4: Tennessee Titans (3-13)
    • The Titans lost last week and are a 12.5-point underdog against the Jaguars to make it two straight
  • No. 5: Arizona Cardinals (3-13)
    • The Cardinals are on an eight game slide and are a 7-point underdog versus the Rams
  • No. 6: Cleveland Browns (4-12)
    • The Browns won last week but are a 7.5-point underdog at the Bengals
  • No. 7: Washington Commanders (4-12)
    • The Commanders enter off two losses but are only a 4-point underdog at the Eagles

Panthers vs. Buccaneers odds: NFC South title game

Seahawks vs. 49ers: NFC West title game

Ravens vs. Steelers odds: AFC North title game

NFL Week 18 odds and lines

There's an advantage to betting early NFL odds when attempting to beat the closing line with your NFL Week 18 predictions. The closer you wait until kickoff to make your picks, the harder it becomes to identify edges and secure the best price on most sides or totals.

Who's playing on prime time in Week 18?

We have three prime-time games in Week 18, with divisions on the line. The Buccaneers host the Panthers for the NFC South on Saturday at 4:30 p.m. ET, and the 49ers finish the day against the visiting Seahawks to claim the NFC West at 8 p.m. ET. The regular season wraps with AFC North foes clashing for the division as the Pittsburgh Steelers host the Baltimore Ravens at 8:29 p.m. ET


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