Bills vs. Jaguars Prediction, Best Bets Today: Wild Card Weekend Expert Picks
Iβm riding with Jacksonville in my Bills vs. Jaguars prediction for todayβs 1 p.m. ET Wild Card matchup at EverBank Stadium on ESPN, with a strong performance from Trevor Lawrence being a huge reason why.
The Jaguars are the 1.5-point home betting favorite for the anticipated clash. As part of the NFL playoff predictions, I've featured an anytime TD scorer pick along with a final score projection.
π Bills vs. Jaguars prediction: NFL Wild Card Weekend
See the latest NFL odds and our experts' NFL picks for every game this postseason.
| Predictions | Best odds | Confidence |
|---|---|---|
| Jaguars ML | -108 via FanDuel | βββββ |
| Under 51.5 | -105 via FanDuel | ββββ |
| Trevor Lawrence anytime touchdown | +170 via FanDuel | βββ |
π° Bills vs. Jaguars best bet: Jaguars moneyline (-108) βββββ
Follow all of our NFL analysis and betting advice for the 2026 NFL playoffs.
"But this might be the only time Josh Allen has a run in him with Patrick Mahomes out of the playoffs!" Yea, football doesn't care. The Jaguars are one of the most complete teams in the league, boasting a top-10 pass defense alongside the league's best run-stopping unit. Trevor Lawrence surged up the NFL MVP odds board down the stretch and is playing the best football of his career. It's a different feeling in Jacksonville this year, leading me to believe they might make a deep run.
Score prediction: Jaguars 24, Bills 21
π Best Bills vs. Jaguars touchdown scorer prediction: Trevor Lawrence (+170) βββ
See all of our NFL touchdown props for the 2026 NFL playoffs.
Lawrence was a straight-up force down the stretch, punching in four rushing touchdowns over the final four games of the season. He averaged north of five carries per game during that span, and against a Bills defense that allows opponents to score on nearly 60% of red-zone trips - bottom 10 in the league - the setup is there for Lawrence to find the end zone again.
I also backed Lawrence to hit pay dirt in my Bills vs. Jaguars player props.
ποΈ Most-bet games on Wild Card Weekend
| Game | Spread |
|---|---|
| Green Bay Packers at Chicago Bears | GB -1.5 |
| Buffalo Bills at Jacksonville Jaguars | BUF -1.5 |
| Los Angeles Rams at Carolina Panthers | LAR -10.5 |
π Bills vs. Jaguars odds: NFL Wild Card Weekend
Our live Bills vs. Jaguars odds update in real time.
π Bills vs. Jaguars betting trends: NFL Wild Card Round
| Bills | Statistic | Jaguars |
|---|---|---|
| 12-5 | W-L record | 13-4 |
| 8-9 | ATS record | 12-5 |
| 9-8 | O/U record | 10-7 |
| 5.9 | Yards per play | 5.2 |
| 5.2 | Yards allowed per play | 5.0 |
| +0.1 | Turnover margin | +0.8 |
| 4-1 | Last 5 games | 5-0 |
π Bills vs. Jaguars latest injuries
π€οΈ Bills vs. Jaguars weather: Sunday, 1:00 p.m. ET
There's a slight chance of rain in Jacksonville, according to nflweather.com, but overall, sportsbooks don't seem to expect the weather to factor into this AFC wild-card matchup.
This game has the highest total of the Wild Card Round, with the best sports betting sites offering between 51.5 and 52.5 points.
Our NFL weather report for Wild Card Weekend has more.
πΊ How to watch Bills vs. Jaguars: NFL Wild Card Weekend
- Date: Sunday, Jan. 11, 2026
- Kickoff: 1:00 p.m. ET
- Location: EverBank Stadium (Jacksonville, FL.)
- TV: ESPN
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