Bills vs. Jaguars Player Props & Best Bets: NFL Wild Card Weekend Prop Bets

Buffalo heads to Jacksonville to open Sunday’s action at 1 p.m. ET on ESPN, and it’s time to break down my best Bills vs. Jaguars player props to get you set for kickoff.

The Jaguars are laying 1.5 points at home - can Josh Allen do enough to keep up with the relentless team in Jacksonville, or will Trevor Lawrence guide his guys to a W? Let’s dig in.

🏈 Bills vs. Jaguars player props: NFL Wild Card Weekend

See the latest NFL odds and our experts' NFL picks for every game this season.

💰 Jaguars vs. Bills best prop bet: Josh Allen Over 227.5 passing yards (-114) ⭐⭐⭐⭐

Follow all of our NFL analysis and betting advice for the 2026 NFL playoffs.

We're going to see Superman in this one. At least that's what Josh Allen's teammates think. The Jaguars are undoubtedly the more complete team in this matchup, but the Bills have one X-Factor, and it's their quarterback. If Jacksonville goes up early, expect Buffalo to lean heavily on Allen and his arm. He's gone over this number twice in his last four games, but the playoffs are a different animal. If the No. 1 run-stopping unit limits James Cook, it'll be on Allen to take over.

🔥 More Bills vs. Jaguars prop picks

Trevor Lawrence anytime touchdown (+175)⭐⭐⭐⭐

Lawrence was a certified menace down the stretch, racking up four rushing touchdowns in the final four games of the season. With more than five carries per game during that run, it wouldn’t be a surprise to see him find the end zone again - especially against a Bills defense that lets opponents score nearly 60% of the time once they reach the red zone, a mark that sits firmly in the bottom 10 league-wide.

I also backed Lawrence to hit pay dirt in my Bills vs. Jaguars prediction. 

James Cook Under 79.5 rushing yards (-114) ⭐⭐⭐⭐

Cook and the Buffalo offense could be in for a long game against the Jaguars. Jacksonville has the No. 1-ranked run-stopping unit in football, allowing just 85 yards per game on the ground. The Jags didn't give up a 100-yard rusher all season long. If the Bills are trailing, expect them to abandon the run game and lean on their star QB in this one.

🚀 Bills vs. Jaguars same-game parlay

See all of our NFL same-game parlays for Wild Card Round, and our best NFL parlay betting sites.

• Josh Allen Over 227.5 passing yards
• Trevor Lawrence anytime touchdown
• James Cook Under 79.5 rushing yards

Best SGP odds: +869 via FanDuel

📺 How to watch Bills vs. Jaguars: NFL Wild Card Weekend

• Date: Sunday, Jan. 11, 2026
• Kickoff: 1 p.m. ET
• Location: EverBank Stadium (Jacksonville, FL.)
• TV: ESPN