Best NFL Long Shot Parlay Today: Week 4 Moneyline Picks for Every Game

My best NFL long shot parlay today features three plays, one of which is a 16-leg moneyline parlay that will profit $3,524 if every prediction pans out. 

The NFL picks below are part of the NFL predictions for Week 4. 

💰 My best NFL parlay picks for Week 4

Our NFL player prop odds tool shows the best NFL odds for every market across legal sportsbooks in your area.

I started the five-leg parlay with both Los Angeles teams to secure victory.

The Chargers travel to New York to play the Jaxson Dart-led New York Giants, while the Rams host the surprising Indianapolis Colts. I picked both of those teams to cover in my against-the-spread picks, so backing them on the moneyline is a given.

De'Von Achane had at least seven receptions in two of his three games, J.K. Dobbins hit the Over on this 60.5-yard total in all three games, while Nico Collins busted things open for 104 yards last week against Jacksonville. C.J. Stroud should go to his primary receiver as often against the Tennessee Titans.

The 5-leg parlay will yield a $141.51 profit if every leg hits. 

🎯 My best NFL long-shot parlay for Week 4

I added two legs to my previous 5-leg parlay, making this a 7-leg play that will yield a profit of $500.92 if everything hits.

Both additions feature the total as I've got Under 42.5 points for the Carolina Panthers vs. New England Patriots and the Over for the Colts vs. Rams in La La Land. 

The Panthers have the third-worst offensive DVOA, while New England is ranked 17th.

The Colts head into the game at SoFi Stadium with the top-ranked offensive DVOA, with the Rams sitting in fifth. The perfect conditions at SoFi Stadium should be conducive to these explosive offenses alternating blows.

🚀 My best NFL moneyline parlay picks for every game

So, I've only gone with two underdogs for my 16-leg moneyline parlay, which will yield a $3,524.09 profit on a winning $10 bet. Those underdogs are the Washington Commanders (+110) and the Chicago Bears (+115). 

The Commanders will be without Jayden Daniels and Terry McLaurin, so they have their work cut out for them. However, the Atlanta Falcons have struggled offensively, and Marcus Mariota impressed in his first start of the season against the Las Vegas Raiders.

The Chicago Bears were excellent against the Dallas Cowboys last week, while the Raiders have bitterly disappointed since winning in Week 1 against the New England Patriots. Our Mike Spector also backs the Bears in his upset picks for Week 4. 

❓NFL parlay betting FAQs

What is a parlay bet in the NFL?

A parlay combines multiple bets (spreads, totals, props, or moneylines) into one wager, with all selections needing to win for the bet to cash. Parlays are popular in NFL betting because they offer bigger payouts.

How do NFL parlay odds work?

Parlay odds are calculated by multiplying the odds of each individual selection, which increases both the potential payout and the risk. The more legs you add, the higher the reward but the lower the probability of winning.

Are parlays a smart betting strategy for the NFL?

Parlays can be fun for chasing large payouts but are harder to win consistently. Many sharp bettors prefer single-game wagers, but NFL parlay bets can add excitement when used responsibly.

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