NFL Predictions Week 4: Best Bets & Odds for Every Game

We have one more week before NFL bye weeks come into play, and we're offering our NFL predictions for every Week 4 game - including our NFL picks and live odds for all 16 matchups from Thursday through Monday.

🏈 NFL predictions for Week 4

• Seahawks vs. Cardinals prediction (coming soon)
• Seahawks vs. Cardinals early prediction
• Seahawks vs. Cardinals player props (coming soon)
• Seahawks vs. Cardinals parlay picks (coming soon)
• Seahawks vs. Cardinals anytime touchdown scorer predictions (coming soon)
• Seahawks vs. Cardinals first touchdown scorer predictions (coming soon)
• Seahawks vs. Cardinals expert picks (coming soon)
• Vikings vs. Steelers prediction (coming soon)
• Vikings vs. Steelers early prediction (coming soon)
• Vikings vs. Steelers player props (coming soon)
• Vikings vs. Steelers parlay picks (coming soon)
• Vikings vs. Steelers anytime touchdown scorer predictions (coming soon)
• Saints vs. Bills player props (coming soon)
• Browns vs. Lions player props (coming soon)
• Eagles vs. Buccaneers player props (coming soon)
• Ravens vs. Chiefs prediction (coming soon)
• Ravens vs. Chiefs early prediction
• Ravens vs. Chiefs player props (coming soon)
• Ravens vs. Chiefs parlay picks (coming soon)
• Ravens vs. Chiefs anytime touchdown scorer predictions (coming soon)
• Packers vs. Cowboys prediction (coming soon)
• Packers vs. Cowboys early prediction (coming soon)
• Packers vs. Cowboys player props (coming soon)
• Packers vs. Cowboys parlay picks (coming soon)
• Packers vs. Cowboys anytime touchdown scorer predictions (coming soon)
• Packers vs. Cowboys first touchdown scorer predictions (coming soon)
• Jets vs. Dolphins prediction (coming soon)
• Jets vs. Dolphins early prediction (coming soon)
• Bengals vs. Broncos prediction (coming soon)
• Bengals vs. Broncos early prediction (coming soon)

💰 NFL odds & expert picks: Week 4

Live NFL odds for every Week 4 game; updated in real time.

📊 Seahawks vs. Cardinals odds

• Date: Thursday, Sept. 25
• Kickoff: 8:15 p.m. ET
• Location: State Farm Stadium (Glendale, Ariz.)
• How to watch: Prime Video
• Early pick: Seahawks +1.5 (-110 via DraftKings)

The Seahawks open as a 1.5-point betting favorite over the Cardinals after blowing out the Saints a week ago. Seattle feels like one of the most undervalued teams in the league in my view, and I'll gladly take the points on Mike Macdonald's bunch until the market corrects itself.

📊 Vikings vs. Steelers odds

• Date: Sunday, Sept. 28
• Kickoff: 9:30 a.m. ET
• Location: Croke Park (Dublin, Ireland)
• How to watch: NFL Network
• Early pick: Vikings -1.5 (-105 via FanDuel)

The Vikings open as a 1.5-point betting favorite over the Steelers in this neutral-site matchup in Dublin, Ireland. Minnesota has already signaled that Carson Wentz will start in place of J.J. McCarthy, though I care much more about the way the Vikings' defense has played of late. This feels like a rough spot for Aaron Rodgers and Co. after a narrow win last week in New England.

📊 Saints vs. Bills odds

• Date: Sunday, Sept. 28
• Kickoff: 1 p.m. ET
• Location: Highmark Stadium (Orchard Park, N.Y.)
• How to watch: CBS
• Early pick: Bills -15.5 (-110 via DraftKings)

The Bills open as a 15.5-point betting favorite over the Saints in one of the most lopsided matchups of the 2025 NFL season. I usually shy away from laying this many points on any team, but the Bills are taking no prisoners this year as they seek to end their title drought. Godspeed, Saints bettors.

📊 Titans vs. Texans odds

• Date: Sunday, Sept. 28
• Kickoff: 1 p.m. ET
• Location: NRG Stadium (Houston)
• How to watch: CBS
• Early pick: Titans +7.5 (-120 via FanDuel)

The Texans open as a 7.5-point betting favorite over the Titans in an AFC South clash between two teams seeking their first win. I'm frankly shocked to see Houston laying more than a touchdown given the state of its offensive line, so I'm grabbing this number before it inevitably moves toward Tennessee.

📊 Browns vs. Lions odds

• Date: Sunday, Sept. 28
• Kickoff: 1 p.m. ET
• Location: Ford Field (Detroit)
• How to watch: FOX
• Early pick: Lions -8.5 (-110 via Caesars)

The Lions open as an 8.5-point betting favorite over the Browns in a rare meeting between two of the NFL's most storied (and troubled) franchises. Cleveland's defense might be the most underappreciated unit in the league, but its offense is abysmal enough to bet on a double-digit win for Detroit.

📊 Commanders vs. Falcons odds

• Date: Sunday, Sept. 28
• Kickoff: 1 p.m. ET
• Location: Mercedes-Benz Stadium (Atlanta)
• How to watch: FOX
• Early pick: Falcons +3 (-115 via bet365)

The Commanders open as a 3-point betting favorite over the Falcons with Jayden Daniels (knee) expected to be back for Washington in Week 4. It's easy to fade the Falcons to oblivion after last week's rough outing, but Atlanta looked like a force a week earlier - I'm buying the dip on the home 'dogs.

📊 Eagles vs. Buccaneers odds

• Date: Sunday, Sept. 28
• Kickoff: 1 p.m. ET
• Location: Raymond James Stadium (Tampa, Fla.)
• How to watch: FOX
• Early pick: Buccaneers +3 (-110 via Caesars)

The Eagles open as a 3-point betting favorite over the Buccaneers in a matchup between divisional winners last season. This bet is less about Philly's slow start last week and more about my belief that Tampa Bay is a tough team to close out - especially on the road following a draining win for the Eagles.

📊 Panthers vs. Patriots odds

• Date: Sunday, Sept. 28
• Kickoff: 1 p.m. ET
• Location: Gillette Stadium (Foxborough, Mass.)
• How to watch: CBS
• Early pick: Patriots -4.5 (-105 via DraftKings)

The Patriots open as a 4.5-point betting favorite over the Panthers in just their sixth meeting since the Super Bowl in 2004. Carolina is riding high after blowing out the Falcons in a game that went the Panthers' way from the jump, but they looked like the NFL's worst team before that. Don't buy it.

📊 Chargers vs. Giants odds

• Date: Sunday, Sept. 28
• Kickoff: 1 p.m. ET
• Location: MetLife Stadium (East Rutherford, N.J.)
• How to watch: CBS
• Early pick: Chargers -5.5 (-115 via Caesars)

The Chargers open as a 5.5-point betting favorite over the Giants in a matchup between a 3-0 contender and an 0-3 doormat. Do we know who will be under center for New York - and does it matter? Los Angeles looks like a legitimate force on both sides of the ball, and I'd expect a comfortable win at home.

📊 Jaguars vs. 49ers odds

• Date: Sunday, Sept. 28
• Kickoff: 4:05 p.m. ET
• Location: Levi's Stadium (Santa Clara, Calif.)
• How to watch: CBS
• Early pick: Jaguars +4.5 (-115 via DraftKings)

The 49ers open as a 4.5-point betting favorite over the Jaguars after surviving the Cardinals last week en route to a 3-0 start. I'm not convinced that San Francisco is the better team in this matchup, and I keep waiting for Jacksonville to catch a break - don't be surprised if the Jags win this outright.

📊 Colts vs. Rams odds

• Date: Sunday, Sept. 28
• Kickoff: 4:05 p.m. ET
• Location: SoFi Stadium (Inglewood, Calif.)
• How to watch: CBS
• Early pick: Rams -3.5 (-105 via Caesars)

The Rams open as a 3.5-point betting favorite over the Colts after blowing a 19-point lead against the Eagles in Week 3. I take no pleasure in fading the undefeated Colts on a weekly basis, but this is Indy's toughest test yet against an L.A. side that will be eager to erase the bitter taste from last week's loss.

📊 Bears vs. Raiders odds

• Date: Sunday, Sept. 28
• Kickoff: 4:25 p.m. ET
• Location: Allegiant Stadium (Las Vegas)
• How to watch: FOX
• Early pick: Bears +1.5 (-115 via FanDuel)

The Raiders open as a 1.5-point betting favorite over the Bears in a compelling clash between 1-2 teams with new head coaches. I'm a bit surprised that Chicago isn't a consensus road favorite after a bounce-back effort for Ben Johnson and Co. last week, especially with Las Vegas looking listless for two straight weeks.

📊 Ravens vs. Chiefs odds

• Date: Sunday, Sept. 28
• Kickoff: 4:25 p.m. ET
• Location: GEHA Field at Arrowhead Stadium (Kansas City)
• How to watch: CBS
• Early pick: Ravens -2.5 (-110 via BetMGM)

The Ravens open as a 2.5-point betting favorite over the Chiefs in a rematch of last week's Week 1 thriller at Arrowhead Stadium. Lamar Jackson has struggled to get the best of Patrick Mahomes over the years, but Baltimore looks like the best team in the NFL - that's enough for me to lay a field goal in this matchup.

📊 Packers vs. Cowboys odds

• Date: Sunday, Sept. 28
• Kickoff: 8:20 p.m. ET
• Location: AT&T Stadium (Arlington, Texas)
• How to watch: NBC
• Early pick: Packers -5.5 (-115 via DraftKings)

The Packers open as a 5.5-point betting favorite over the Cowboys in Micah Parsons' return to Dallas after a blockbuster trade late last month. I don't love the number here, but I do think Green Bay is miles ahead of Dallas on the field - even after a lazy finish to last week's loss. Expect a strong response in Week 4.

📊 Jets vs. Dolphins odds

• Date: Monday, Sept. 29
• Kickoff: 7:15 p.m. ET
• Location: Hard Rock Stadium (Miami Gardens, Fla.)
• How to watch: ESPN
• Early pick: Jets +2.5 (-105 via Caesars)

The Dolphins open as a 2.5-point betting favorite over the Jets in a prime-time battle between winless AFC East squads. Even after an inspired effort in last week's loss to the Bills, I haven't seen enough from Miami to lay points on the 'Fins as a favorite - though I'd rather bet the Under than trust either offense.

📊 Bengals vs. Broncos odds

• Date: Monday, Sept. 29
• Kickoff: 8:15 p.m. ET
• Location: Empower Field at Mile High (Denver)
• How to watch: ESPN
• Early pick: Bengals +7.5 (-110 via DraftKings)

The Broncos open as a 7.5-point betting favorite over the Bengals after both teams suffered tough losses last week. Cincinnati was blown out in Jake Browning's first start of the season, but we've seen him lead this offense to impressive heights before - a touchdown margin feels much too wide in this matchup.

💡 NFL expert picks for Week 4

• NFL picks against the spread Week 4 (coming soon)
• NFL fantasy pickup player props Week 4 (coming soon)
• NFL weather report Week 4 (coming soon)
• NFL QB clutch player ratings Week 4 (coming soon)
• NFL rookie player props Week 4 (coming soon)
• NFL survivor picks Week 4 (coming soon)
• NFL upset picks Week 4 (coming soon)
• NFL moneyline picks Week 4 (coming soon)
• How to bet Week 4 on a $20 budget (coming soon)
• NFL AI predictions Week 4 (coming soon)
• NFL player props Week 4 (coming soon)
• NFL expert picks Week 4 (coming soon)
• NFL live betting guide Week 4 (coming soon)
• NFL anytime touchdown scorer predictions Week 4 (coming soon)
• NFL anytime touchdown scorer parlay Week 4 (coming soon)
• NFL best bets Week 4 (coming soon)
• NFL long-shot parlay Week 4 (coming soon)

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