NFL Week 2 Against the Spread Picks for Every Game
Week 1 flew by faster than Tyreek Hill on his 80-yard touchdown reception against the Jacksonville Jaguars.
With the opening week in the rearview, let's look ahead to my NFL ATS Week 2 picks. We'll focus on three featured games, one of which involves the second-biggest Super Bowl odds favorite.
Headlined by a few agonizingly near misses (thanks for nothing Buffalo, Miami, and Houston) and an admittedly lucky selection (thanks for everything Bears' defense and special teams), my Week 1 ATS picks went 9-7.
The below ATS picks are part of our comprehensive NFL Week 2 predictions.
NFL ATS picks Week 2: Every game
NFL odds via DraftKings and subject to change; pick confidence based on a 1-to-5-star scale.
| Matchup | Pick | Confidence |
|---|---|---|
| Bills vs. Dolphins (-2.5) | Bills (+2.5) | ⭐⭐⭐ |
| Raiders vs. Ravens (-9.5) | Raiders (+9.5) | ⭐⭐⭐ |
| Saints vs. Cowboys (-6.5) | Cowboys (-6.5) | ⭐⭐⭐⭐ |
| Seahawks (-3.5) vs. Patriots | Seahawks (-3.5) | ⭐⭐⭐⭐ |
| Chargers (-6.5) vs. Panthers | Chargers (-6.5) | ⭐⭐⭐ |
| Colts (-3) vs. Packers | Colts (-3) | ⭐⭐⭐⭐ |
| 49ers (-6) vs. Vikings | 49ers (-6) | ⭐⭐⭐⭐ |
| Buccaneers vs. Lions (-7) | Buccaneers (+7) | ⭐⭐⭐ |
| Jets (-3.5) vs. Titans | Jets (-3.5) | ⭐⭐⭐⭐ |
| Browns vs. Jaguars (-3) | Jaguars (-3) | ⭐⭐⭐⭐ |
| Giants vs. Commanders (-1.5) | Commanders (-1.5) | ⭐⭐⭐ |
| Rams vs. Cardinals (-1.5) | Rams (+1.5) | ⭐⭐⭐⭐ |
| Bengals vs. Chiefs (-5.5) | Chiefs (-5.5) | ⭐⭐⭐⭐ |
| Steelers (-3) vs. Broncos | Steelers (-3) | ⭐⭐⭐⭐ |
| Bears vs. Texans (-6.5) | Texans (-6.5) | ⭐⭐⭐⭐ |
| Falcons vs. Eagles (-6.5) | Eagles (-6.5) | ⭐⭐⭐⭐ |
My favorite ATS picks this week
NFL picks as of Tuesday. Our NEW NFL player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!
Browns vs. Jaguars (-3)
I made an egregious error in thinking any team led by Deshaun Watson could cover the spread.
Until he is reincarnated as the Houston Texans version of himself or the Cleveland Browns find a way to offload him and his soaking-wet-diaper swollen contract, which could be a possibility with the latest news, I can't get behind the Browns' cause.
The Browns' defense was graded 10th in their Week 1 loss to the Dallas Cowboys.
While a decent grade, the defense must come up with a first-or-second overall caliber performance to stand a chance.
The Jacksonville Jaguars gave the Miami Dolphins everything they could handle but lost grip of the game in the second half, primarily due to a Travis Etienne fumble on the goal line in the third quarter.
The Jaguars would have increased their lead to 17 had Etienne not moisturized his hands before the pivotal play.
The Browns were 2-6-1 ATS on the road last season, and they won't have the injured David Njoku against Jacksonville.
BetMGM and DraftKings have the line at -3, the only two of our best NFL betting sites that haven't increased to -3.5. Take that line while you still can. A $10 wager will yield an $8.70 profit.
Best odds: -115 via BetMGM | Implied probability: 53.48%
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Saints vs. Cowboys (-6.5)
Dak Prescott got paid mere hours before the Dallas Cowboys thrashed the Browns. While Prescott is a consummate professional, it seems illogical to think the suitcases of cash provided by the Cowboys didn't considerably help his psyche.
Fast forward to Week 2 at AT&T Stadium.
CeeDee Lamb and Prescott both got Scrooge McDuck rich, so vibes in the locker room must be as euphoric as the idyllic scene in the movie "The Beach" before things went sideways.
Not to mention Micah Parsons, who would not be upstaged by his offensive colleagues.
Remember, Parsons is also in the running for a new contract, albeit in the slightly more distant future.
The Cowboys scored an average of 37 points per game and were 6-2 ATS at home last season.
Meanwhile, the New Orleans Saints thrashed the Carolina Panthers, who appeared better suited for the XFL.
Take that result with a grain of salt.
The Saints were 3-5-1 ATS on the road last season, and that losing record should continue in Big D.
The -110 odds will profit $9.09 on a winning $10 bet.
Best odds: -110 via BetMGM | Implied probability: 52.36%
Bonus bets will expire in 7 days. One new customer offer only. Additional terms and conditions apply.
49ers (-6) vs. Vikings
The San Francisco 49ers' offense was in motion against the New York Jets more than a flimsy dingy on the open seas during a tropical storm.
It featured motion on 90% of its Monday night snaps, the second-highest of Week 1 behind, you guessed it, Miami (91%).
Kyle Shanahan's team also showcased its seemingly bottomless depth, with backup running back Jordan Mason racking up 147 yards (the second-most in Week 1) on 28 carries in Christian McCaffrey's absence.
Among the Offensive Player of the Year odds front-runners, McCaffrey, while is listed as day-to-day, has Achilles tendonitis, which can flare up at any moment. His status is unclear for Sunday.
Even if he doesn't play, I like the 49ers' chances.
Brock Purdy, graded third among passers in Week 1 and among the NFL MVP odds leaders, was outstanding against the Jets, while Brandon Aiyuk and Trent Williams should be rust-free in Minnesota for the Week 2 encounter against the Vikings.
Sam Darnold and the Vikings played well against the New York Giants, but, like the Saints' win over the Panthers, I won't be reading too much into that result.
The 49ers are 6-point favorites at four of our best sports betting apps, with FanDuel (-6.5) the only exclusion. The -110 is the consensus line at the aforementioned quartet.
Best odds: -110 via bet365 | Implied probability: 52.36%
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