NFL Player Props for Week 10: Best O/U Prop Bets & TD Picks This Week

Christian McCaffrey leads our NFL Week 10 player prop picks. We're examining roles, usage, and matchups behind our best bets.
Christian McCaffrey, featured in our NFL Player Props for Week 10, celebrating with a teammate.
Pictured: Christian McCaffrey, featured in our NFL Player Props for Week 10, celebrating with a teammate. Photo by Stan Szeto via Imagn Images
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My NFL player props for Week 10 feature Christian McCaffrey, George Kittle, and Bryce Young. I've also added two bonus picks from the Buffalo Bills vs. New York Jets game.

I cashed three out of five prop picks in Week 9. Let's get into the best bets for the forthcoming weekend slate.


NFL player prop bets for Week 10

See the latest NFL odds and our experts' NFL picks for every game this season.

Player Prop bet Best odds
Christian McCaffrey Over 61.5 rushing yards -114 via FanDuel 
George Kittle  Over 62.5 receiving yards -114 via FanDuel
Bryce Young  Over 244.5 passing yards  -114 via FanDuel
Bonus pick: James Cook Over 91.5 rushing yards -110 at bet365
Bonus pick: Josh Allen  Anytime TD -160 via BetMGM

Picks submitted: Nov. 12 at 5 p.m. ET. Odds subject to change. 

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Best NFL player props this week

Christian McCaffrey Over 61.5 rushing yards (-114)

McCaffrey rushed for at least 64 yards in three of the previous four games, and he's facing a Dallas Cowboys team with a notoriously poor run defense. The Cowboys rank 28th in defensive run DVOA and allow the most yards per carry (5), tied with two other teams. 

I expect the game script to help facilitate McCaffrey's Over. If the Cowboys keep things close at home, McCaffrey will be utilized in the run game throughout. And if the 49ers gain separation, McCaffrey should be an influential part in controlling the clock for the away team. 

⏰️ Set your alarm: 49ers vs. Cowboys

  • Kickoff: Sunday, 4:25 p.m. ET
  • Venue: AT&T Stadium (Arlington, Texas)
  • How to watch: FOX

George Kittle Over 62.5 receiving yards (-114)

Kittle surpassed this threshold in five of the previous seven games. The Cowboys have the third-worst defensive pass DVOA, and Brock Purdy will likely target Kittle more this week, especially with the likely absence of Mike Evans.

Kittle has been targeted 8.3 times per game over the last three, his highest average of any three-game stretch this season. 

Fantasy Pros projects him for 68.8 receiving yards in the matchup, which, excluding the opener where he had only 12 yards, is close to his game average of 67.3. 

Bryce Young Over 244.5 passing yards (-114)

Young hit the Over on this total in six of eight games this season, and he broke a two-game Under streak in Week 9 with a 276-yard performance against the Denver Broncos. Averaging 275 yards per game, Young will face a New Orleans Saints defense that allows 11.1 yards per reception, the seventh-most (tied with Baltimore). 

The Saints also have the fourth-worst pass defense via DVOA and conceded an average of 277 passing yards over the previous three games. 

⏰️ Set your alarm: Panthers vs. Saints 

  • Kickoff: Sunday, 1 p.m. ET
  • Venue: Caesars Superdome (New Orleans)
  • How to watch: FOX

💡 More NFL predictions

Want more NFL betting advice? Check out all of our NFL analysis and expert predictions for every game this season.