NFL Odds & Week 10 Schedule | Betting Lines, Spreads and Totals for Every Game
NFL odds Week 10, 2026
The NFL odds for Week 10 are via bet365.
| Game | Spread | Moneyline | Over/Under |
|---|---|---|---|
| Commanders vs. Giants (TNF) | Giants -1.5 | WAS +108 / NYG -128 | 43.5 |
| Patriots vs. Lions (from Munich) | Lions -2.5 | NE +124 / DET -148 | 51.5 |
| Bills vs. Jets | Bills -7.5 | BUF -460 / NYJ +355 | 51.5 |
| Panthers vs. Saints | Panthers -1.5 | CAR -113 / NO -107 | 47.5 |
| Texans vs. Browns | Texans -4.5 | HOU -210 / CLE +175 | 39.5 |
| Jaguars vs. Titans | Jaguars -9.5 | JAX -490 / TEN +370 | 47.5 |
| Chiefs vs. Falcons | Chiefs -3.5 | KC -178 / ATL +149 | 45.5 |
| Dolphins vs. Colts | Colts -2.5 | MIA +116 / IND -136 | 40.5 |
| Vikings vs. Packers | Packers -3.5 | MIN +147 / GB -174 | 42.5 |
| Rams vs. Cardinals | Rams -7.5 | LAR -350 / ARI +275 | 44.5 |
| Seahawks vs. Raiders | Seahawks -3.5 | SEA -169 / LV +144 | 43.5 |
| 49ers vs. Cowboys | 49ers -4.5 | SF -220 / DAL +180 | 55.5 |
| Steelers vs. Bengals (SNF) | Bengals -3.5 | PIT +163 / CIN -196 | 47.5 |
| Chargers vs. Ravens (MNF) | Ravens -5.5 | LAC +190 / BAL -235 | 38.5 |
Our NFL picks will be locked and loaded for Week 9 as the league heads back to Europe
- The week starts with a TNF NFC East rematch between the Giants (-1.5) and Commanders from MetLife Stadium; kickoff is at 8:15 p.m. ET (Prime Video)
- The Patriots return to Germany to face the Lions (-2.5) at Allianz Arena in Munich; kickoff is 9:30 a.m. ET (NFL Network)
- Sunday finishes up the Steelers and Bengals (-3.5) on Sunday Night Football; kickoff from Paycor Stadium in Cincinnati at 8:20 p.m. ET (NBC)
- It's too bad flex rules can't help us out on Monday as the Chargers and Ravens (-5.5) meet at M&T Bank Stadium to wrap up the week; kickoff at 8:15 p.m. ET (ESPN)
- The Chicago Bears (7-2), Denver Broncos (7-2), Philadelphia Eagles (2-7), and Tampa Bay Buccaneers (3-6) are on bye
Commanders vs. Giants: Thursday Night Football
- Kickoff: 8:20 p.m. ET from MetLife Stadium (East Rutherford, N.J.)
- How to watch: Prime Video
Patriots vs. Lions (from Munich)
- Kickoff: 9:30 a.m. ET from Allianz Arena (Munich)
- How to watch: NFL Network
Steelers vs. Bengals: Sunday Night Football
- Kickoff: 8:20 p.m. ET from Paycor Stadium (Cincinnati)
- How to watch: NBC
Chargers vs. Ravens: Monday Night Football
- Kickoff: 8:15 p.m. ET from M&T Bank Stadium (Baltimore)
- How to watch: ESPN
NFL Week 10 odds and lines
There's an advantage to betting early NFL odds when attempting to beat the closing line with your NFL predictions. The closer you wait until kickoff to make your picks, the harder it becomes to identify edges and secure the best price on most sides or totals.
Who's playing on prime time in Week 10?
We have four prime-time games in Week 10, starting with the Giants hosting the Commanders on Thursday Night Football. The league stays in Europe as the Patriots and Lions tussle in Munich.
Sunday Night Football is an AFC North clash between the rival Bengals and Steelers, while the week finishes up with the winless Chargers and the Ravens.
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