March Madness Sweet 16 Schedule Today: 2025 NCAA Tournament Sweet 16 Game Info, Odds

There's no way around it: the first two rounds of March Madness were about as chalky as it gets. The following seeds advanced: All four No. 1 seeds, three No. 2 seeds, two No. 3 seeds, three No. 4 seeds, one No. 5 seed, two No. 6 seeds, and a No. 10 seed.  

Kudos to No. 10 Arkansas, the final double-digit domino to fall in the Sweet 16, which concludes tonight. The best thing about chalky tournaments is the elite head-to-head matchups in the latter rounds.

The 2025 March Madness Sweet 16 schedule and odds are full of the nation's best, including the March Madness odds favorite Duke Blue Devils. The schedule and NCAA Tournament Sweet 16 betting lines below, including game times and TV schedule, will crank the excitement dial.

We offer our best bets for each game with our March Madness Sweet 16 predictions.

🗓️ March Madness Sweet 16 schedule

Here is the remaining March Madness Sweet 16 schedule for today. Listed odds are from BetMGM.

👉 See all of the college basketball odds from our best March Madness betting sites.

🏀 Sweet 16 odds & predictions for today 

Here are Friday's March Madness odds:

No. 2 Michigan State vs. No. 6 Ole Miss odds, 7:09 p.m. ET

• When: Friday, March 28 | 7:09 p.m. ET
• Where: State Farm Arena (Atlanta)
• How to watch: CBS
• Michigan State vs. Ole Miss prediction

No. 2 Tennessee vs. No. 3 Kentucky odds, 7:39 p.m. ET

• When: Friday, March 28| 7:39 p.m. ET
• Where: Lucas Oil Stadium (Indianapolis)
• How to watch: TBS/truTV
• Tennessee vs. Kentucky prediction

No. 1 Auburn vs. No. 5 Michigan odds, 9:39 p.m. ET

• When: Friday, March 28| 9:39 p.m. ET
• State Farm Arena (Atlanta)
• How to watch: CBS
• Auburn vs. Michigan prediction | Auburn vs. Michigan player props

No. 1 Houston vs. No. 4 Purdue odds, 10:09 p.m. ET

• When: Friday, March 28| 10:09 p.m. ET
• Where: Lucas Oil Stadium (Indianapolis)
• How to watch: TBS/truTV
• Houston vs. Purdue prediction

⏰ When is March Madness Sweet 16?

The 2025 NCAA Tournament Sweet 16 takes place today with four games. The early games start at 7:09 p.m. ET and 7:39 p.m. ET, while the later games start at 9:39 p.m. ET, and 10:09 p.m. ET. 

🧠 Sweet 16 expert picks

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🆚 Sweet 16 game predictions

• Michigan State vs. Ole Miss prediction
• Michigan State vs. Ole Miss player props
• Tennessee vs. Kentucky prediction
• Tennessee vs. Kentucky player props
• Auburn vs. Michigan prediction
• Auburn vs. Michigan player props
• Houston vs. Purdue prediction
• Houston vs. Purdue player props

💰 March Madness betting odds pages

👑 Best March Madness betting sites

Ready to place your March Madness bets? Check out the best March Madness betting promos from the best March Madness betting sites, as determined by our expert team at Sportsbook Review.

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