Best March Madness Parlay Today: Thursday's Best Moneyline Picks & Bets at +1080383 Odds

To celebrate the first day of the NCAA Tournament, we've put together our best March Madness moneyline parlay based on our expert score predictions.

C Jackson Cowart

Last updated: March 20, 2025 10:44 AM EDT • 10 min read

Pictured: UC San Diego Tritons mascot during practice at Ball Arena. Photo by Ron Chenoy / Imagn Images.

With 16 NCAA Tournament games tipping off today starting at 12:15 p.m. ET, there's no better time to fire off March Madness parlay bets to sweat from sunrise to sunset.

Our March Madness parlay features +1080383 odds based on moneyline picks from our college basketball experts. That would turn a $10 bet into a $108,038.30 profit. While it's tough to pull off a clean sweep on Day 1, it's worth a shot at a payday of a lifetime, right?

👉 Can't get enough March Madness action? Check out the rest of our March Madness first-round expert picks as part of our March Madness predictions.

A custom graphic of our March Tourney Survivor contest with $1,000 cash to the winner!

💰 Our best March Madness parlay bets today for the NCAA Tournament

📅 Check out the full March Madness first-round schedule & opening odds.

🔥 Louisville (-155) vs. Creighton
🔥 High Point (+290) vs. Purdue
🔥 Wisconsin (-2000) vs. Montana
🔥 Houston (-10000) vs. SIU Edwardsville
🔥 Auburn (-10000) vs. Alabama State
🔥 Clemson (-350) vs. McNeese
🔥 VCU (+115) vs. BYU
🔥 Gonzaga (-300) vs. Georgia
🔥 Tennessee (-3000) vs. Wofford
🔥 Kansas (-220) vs. Arkansas
🔥 Texas A&M (-350) vs. Yale
🔥 Drake (+210) vs. Missouri
🔥 Utah State (+195) vs. UCLA
🔥 St. John's (-3000) vs. Omaha
🔥 UC San Diego (+118) vs. Michigan
🔥 Texas Tech (-1400) vs. UNC Wilmington

🚀 Best parlay odds: +1080383 via BetMGM ($10 to win $108,038.30)

🏀 March Madness score predictions & moneyline odds for every game

Our NEW college basketball player prop odds tool can help you find the best odds for any March Madness market across legal sportsbooks in your area!

🔮 Louisville vs. Creighton score prediction & moneyline odds (12:15 p.m. ET, CBS)

🎯 Score prediction: Louisville 73, Creighton 69
💰 Best Louisville moneyline odds: -145 (ESPN BET)

Here's why Mike Spector is picking Louisville to win outright:

"The Cardinals average 78.6 points per game, and the Bluejays average 75.2. Yet, even with the offensive prowess of both teams, I expect this to be a low-scoring game.

Both teams allow fewer than 70 points per game, and there are bound to be some nerves with this being the first game of the NCAA Tournament. This game will be close, and it wouldn’t surprise me if either team wins. However, I’m backing the Cardinals."

👉 For more analysis, check out our Louisville vs. Creighton prediction.

📊 Louisville vs. Creighton odds

🔮 Purdue vs. High Point score prediction & moneyline odds (12:40 p.m. ET, truTV)

🎯 Score prediction: High Point 79, Purdue 75
💰 Best High Point moneyline odds: +290 (ESPN BET)

Here's why Brenden Schaeffer is picking High Point to win outright:

"In recent March Madness history, we’ve seen 13 seeds find success over 4 seeds, with three of the past four tournaments seeing at least one 13-over-4 upset. I’m going out on the limb that the Panthers can be the team to get it done in 2025."

👉 For more analysis, check out our Purdue vs. High Point prediction.

📊 Purdue vs. High Point odds

🔮 Wisconsin vs. Montana score prediction & moneyline odds (1:30 p.m. ET, TNT)

🎯 Score prediction: Wisconsin 85, Montana 65
💰 Best Wisconsin moneyline odds: -1429 (Caesars)

Here's why Mike Spector is picking Wisconsin to win outright:

"Montana ended the season with 14 wins in its last 15 games but lost its three games against NCAA Tournament competition by an average of 26 points. Thus, I am backing the Badgers to cover their first NCAA Tournament game since 2021 (0-3 ATS in that span)."

👉 For more analysis, check out our Wisconsin vs. Montana prediction.

📊 Wisconsin vs. Montana odds

🔮 Houston vs. SIU Edwardsville score prediction & moneyline odds (2 p.m. ET, TBS)

🎯 Score prediction: Houston 77, SIU Edwardsville 51
💰 Best Houston moneyline odds: -10000 (BetMGM)

Here's why Brenden Schaeffer is picking Houston to win outright:

"SIU Edwardsville's team total points sit at a paltry 49.5 at FanDuel, a sign that the market doesn’t expect the Cougars to penetrate the vaunted Houston defense ... Houston’s methodical pace relative to those teams lends itself to a low-scoring SIU Edwardsville game, but I’m predicting Ohio Valley’s Cougars to play for pride and sneak over 50 points in garbage time."

👉 For more analysis, check out our Houston vs. SIU Edwardsville prediction.

📊 Houston vs. SIU Edwardsville odds

🔮 Auburn vs. Alabama State score prediction & moneyline odds (2:50 p.m. ET, CBS)

🎯 Score prediction: Auburn 99, Alabama State 63
💰 Best Auburn moneyline odds: -10000 (BetMGM)

Here's why Phil Wood is picking Auburn to win outright:

"The Tigers enter this game with the 20th-best field-goal percentage in the nation. They’re going to light up the scoreboard, shooting over 50%. They’ll dominate on the boards, leading to increased possessions, and the defense will prevent the Hornets from getting anywhere near their average of 72.1."

👉 For more analysis, check out our Auburn vs. Alabama State prediction.

📊 Auburn vs. Alabama State odds

🔮 Clemson vs. McNeese score prediction & moneyline odds (3:15 p.m. ET, truTV)

🎯 Score prediction: Clemson 72, McNeese 61
💰 Best Clemson moneyline odds: -303 (Caesars)

Here's why Brenden Schaeffer is picking Clemson to win outright:

"McNeese dominated the Southland and nearly caught Alabama and Mississippi State napping in close losses earlier in the year, but the Cowboys rank 235th nationally in free-throw percentage - another reason I expect this game to slip out of reach for the underdogs."

👉 For more analysis, check out our Clemson vs. McNeese prediction.

📊 Clemson vs. McNeese odds

🔮 BYU vs. VCU score prediction & moneyline odds (4:05 p.m. ET, TNT)

🎯 Score prediction: VCU 75, BYU 74
💰 Best VCU moneyline odds: +115 (bet365)

Here's why Mike Spector is picking VCU to win outright:

"VCU played at altitude against Colorado State in Las Vegas and at New Mexico this season, splitting those two games against NCAA Tournament teams. The fact that No. 11 seeds have won half of the 24 meetings with No. 6 seeds since 2018 has me even more confident in predicting an upset."

👉 For more analysis, check out our BYU vs. VCU prediction.

📊 BYU vs. VCU odds

🔮 Gonzaga vs. Georgia score prediction & moneyline odds (4:35 p.m. ET, TBS)

🎯 Score prediction: Gonzaga 80, Georgia 74
💰 Best Gonzaga moneyline odds: -275 (FanDuel)

Here's why Brenden Schaeffer is picking Gonzaga to win outright:

"Gonzaga runs a top-50 adjusted tempo in the nation, which could speed up a Georgia team that ranks outside the top 200 in adjusted tempo. Still, we’ve got Gonzaga falling slightly below its season scoring average of 86.6 points per game due to Georgia’s 26th-ranked adjusted defensive efficiency according to KenPom."

👉 For more analysis, check out our Gonzaga vs. Georgia prediction.

📊 Gonzaga vs. Georgia odds

🔮 Tennessee vs. Wofford score prediction & moneyline odds (6:50 p.m. ET, TNT)

🎯 Score prediction: Tennessee 78, Wofford 57
💰 Best Tennessee moneyline odds: -2000 (Caesars)

Here's why Brenden Schaeffer is picking Tennessee to win outright:

"Tennessee has the top-ranked adjusted defensive efficiency in the country and should stymie Wofford in a manner somewhat comparable to what the Terriers experienced when they mustered just 35 points in a loss to Duke earlier this season."

👉 For more analysis, check out our Tennessee vs. Wofford prediction.

📊 Tennessee vs. Wofford odds

🔮 Kansas vs. Arkansas score prediction & moneyline odds (7:10 p.m. ET, CBS)

🎯 Score prediction: Kansas 73, Arkansas 71
💰 Best Kansas moneyline odds: -210 via FanDuel (FanDuel)

Here's why Isaiah Sirois is picking Kansas to win outright:

"Balancing both sides’ above-average pace with their top-25 adjusted defensive ratings since Feb. 1 is tricky, especially with both sides continuing to defend well in Quad 1 games. The Arkansas injury report makes this game even harder to handicap, as their recent results reflect a different team than the one we’ll see on Thursday."

👉 For more analysis, check out our Kansas vs. Arkansas prediction.

📊 Kansas vs. Arkansas odds

🔮 Texas A&M vs. Yale score prediction & moneyline odds (7:25 p.m. ET, TBS)

🎯 Score prediction: Texas A&M 81, Yale 68
💰 Best Texas A&M moneyline odds: -323 (Caesars)

Here's why Phil Wood is picking Texas A&M to win outright:

"These are two high-scoring teams, but the Aggies’ 50th-ranked scoring defense is ultimately going to be too much for the Bulldogs to overcome. Led by Poulakidas, the Bulldogs will knock down plenty of threes, but if they start missing shots, they simply won’t have an alternative to get back on track and stop any Aggies’ runs."

👉 For more analysis, check out our Texas A&M vs. Yale prediction.

📊 Texas A&M vs. Yale odds

🔮 Missouri vs. Drake score prediction & moneyline odds (7:35 p.m. ET, truTV)

🎯 Score prediction: Drake 65, Missouri 64
💰 Best Drake moneyline odds: +215 (FanDuel)

Here's why Isaiah Sirois is picking Drake to win outright:

"Let’s not forget that before the Tigers won their opening-round SEC tournament matchup, they were on a three-game losing skid, falling at Vanderbilt, at Oklahoma, and to Kentucky. The win over Mississippi State was nice, but immediately getting smacked by Florida had to hurt. In contrast, Drake is riding high off a tournament win."

👉 For more analysis, check out our Missouri vs. Drake prediction.

📊 Missouri vs. Drake odds

🔮 UCLA vs. Utah State score prediction & moneyline odds (9:25 p.m. ET, TNT)

🎯 Score prediction: Utah State 76, UCLA 74
💰 Best Utah State moneyline odds: +198 (FanDuel)

Here's why Brenden Schaeffer is picking Utah State to win outright:

"Utah State has the chops to fulfill (a Cinderella) role this year. Still, it’s honestly more about UCLA’s inconsistency than anything else—and at 247th in the nation in free-throw percentage, the favored Bruins are simply asking for trouble if they allow Utah State to hang around."

👉 For more analysis, check out our UCLA vs. Utah State prediction.

📊 UCLA vs. Utah State odds

🔮 St. John's vs. Omaha score prediction & moneyline odds (9:45 p.m. ET, CBS)

🎯 Score prediction: St. John’s 85, Omaha 62
💰 Best St. John's moneyline odds: -2000 (Caesars)

Here's why Isaiah Sirois is picking St. John's to win outright:

"While some 15-seeds are exciting (remember Dunk City?), I can’t get excited about a 22-12 Summit League team that showed little life against its lone big-name opponent this year. This game is also in Providence, so look for St. John’s to draw a massive home crowd en route to a big win."

👉 For more analysis, check out our St. John's vs. Omaha prediction.

📊 St. John's vs. Omaha odds

🔮 Michigan vs. UC San Diego score prediction & moneyline odds (10 p.m. ET, TBS)

🎯 Score prediction: UC San Diego 65, Michigan 63
💰 Best UC San Diego moneyline odds: +126 (FanDuel)

Here's why Phil Wood is picking UC San Diego to win outright:

"The Wolverines are hot entering this tournament, but I worry that having four days off between the Big Ten championship and their first-round game against UC San Diego will cool them off. This team lost four of six to end the regular season, including an ugly 20-point loss to Illinois."

👉 For more analysis, check out our Michigan vs. UC San Diego prediction.

📊 Michigan vs. UC San Diego odds

🔮 Texas Tech vs. UNC Wilmington score prediction & moneyline odds (10:10 p.m. ET, truTV)

🎯 Score prediction: Texas Tech 82, UNC Wilmington 60
💰 Best Texas Tech moneyline odds: -1111 (Caesars)

Here's why Isaiah Sirois is picking Texas Tech to win outright:

"When UNC Wilmington lost to Kansas by 18 earlier in the season, it was with a final tally of 84-66, not far from where we’re at here. I’m not especially high on the Big 12, but I am high on this red-hot Red Raiders team, and I’m pretty low on a Coastal Athletic Association that nearly gave a tournament bid to the Delaware Blue Hens (16-20)."

👉 For more analysis, check out our Texas Tech vs. UNC Wilmington prediction.

📊 Texas Tech vs. UNC Wilmington odds

🏀 Best March Madness odds, predictions & expert picks today

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Written By:
C Jackson Cowart

C Jackson Cowart is a publishing editor and lead writer for Sportsbook Review. An award-winning writer, reporter, and editor with a decade of sports media experience, "C-Jax" has worked with ESPN, Forbes, theScore, and various daily newspapers before joining the Sportsbook Review team. He's a proud graduate of the University of North Carolina, where he served as a beat writer for the Tar Heels' championship run through the NCAA men's basketball tournament in 2017. Jackson has spent the last five years covering sports betting as a predictive analyst, features writer, and industry reporter. Since joining the team in 2023, he's played a key role in Sportsbook Review's coverage of the Super Bowl, March Madness, and NBA playoffs while serving as the lead writer for the growing WNBA and NASCAR betting scenes. Though he's cashed some big bets over the years -- including Lamar Jackson to win MVP (twice) -- he's still haunted by enough second-place bet slips to wallpaper his home office. While Jackson is a committed "process over results" bettor with a keen eye for advanced stats and subtle bias in futures markets, he also embraces sports betting as a vehicle for entertainment and personal investment. He's written about everything from hot dogs to groundhogs and still hasn't forgiven his "inside source" for a sabotaged bet on the Gatorade color in Super Bowl LV.