Astros vs. Blue Jays Prediction, Odds & Expert Picks: MLB Best Bets for Sept. 10

My Astros vs. Blue Jays prediction expects a high-scoring game featuring two pitchers who have been giving up a ton of traffic on the bases.
Astros vs. Blue Jays Prediction, Odds & Expert Picks: MLB Best Bets for Sept. 10
Pictured: Toronto Blue Jays first baseman Vladimir Guerrero Jr. (27) reacts after hitting an infield single. Photo by: John Jones-Imagn Images

Look at that team in Canada - who would've thought? The Toronto Blue Jays seek to continue their run for the American League East crown when they host the Houston Astros tonight, and I break down Game 2 of the series with my Astros vs. Blue Jays prediction as part of my MLB picks.   

The Blue Jays are the -142 moneyline betting favorite, but the total of 9 runs is catching my eye because both starting pitchers have been giving up some hard contact recently.

One of baseball's hottest hitters is the focus of my best Astros vs. Blue Jays player prop. This matchup is part of a 15-game MLB slate, with the first pitch flying at 7:07 p.m. ET from the Rogers Centre in Toronto, Ontario.


⚾ Astros vs. Blue Jays prediction

MLB expert picks odds subject to change.

  • Moneyline pick: Blue Jays (-142 via FanDuel) ⭐⭐⭐
  • Run line pick: Astros +1.5 (-172 via FanDuel) ⭐⭐⭐
  • Over/Under pick: Over 9 (-110 via DraftKings) ⭐⭐⭐⭐

📝 Astros vs. Blue Jays preview & best bet

Track the latest MLB scores for line movement and matchup info.

⬆️ Over 9 (-110) ⭐⭐⭐⭐

The Blue Jays are facing a Jose Berrios problem.

"La Makina" has been enduring issues with his velocity this season and is down a full tick from the veteran's 2024 campaign (and two ticks since 2023). Aside from lasting just two innings during his previous start against the Cincinnati Reds (five hits, six runs against, two earned), he's only striking this Astros team out at a 13% clip across 123 plate appearances. 

Berrios also owns the highest barrel percentage (11.1%) of his career, and the second-highest average exit velocity (90.1 mph) since his rookie age-22 season. We'll be looking for balls to be in play early and often and for a ton of traffic on the basepaths tonight as part of my Astros vs. Blue Jays prediction.

On the other side, Jason Alexander has been going through his own struggles, specifically with keeping the baseball in the ballpark. The right-hander has served up six bombs across his last four starts, and he's going up against one of the best offenses in baseball. The math is adding up.

A $10 winning wager would net $8.33 in profit through DraftKings' -120 odds.


💰 Best Astros vs. Blue Jays player prop bet

Our MLB player prop odds tool shows the best odds for every market across legal sportsbooks in your area.

⬆️ Vladimir Guerrero Jr. Over 1.5 total bases (-115) ⭐⭐⭐⭐

Were you there when I told you Jason Alexander has been struggling with home run issues? Well yeah, that plays a role in our best Astros vs. Blue Jays player prop. 

Not only does the right-hander love to serve up pitches on a platter, but Vladimir Guerrero Jr. might just be the hottest hitter in baseball right now.

Yes, you're seeing this correctly. Vladdy has posted six consecutive multi-hit games, and he's riding an eight-game hit streak with two bombs during that span. His batting average has jumped from .287 to .304 as a result. He's seeing the ball incredibly well, and it's time to ride his bat to the bank tonight.

At betting odds of -115 through FanDuel, a successful $10 bet would reel in $9.52.


📊 Astros vs. Blue Jays odds: Sept. 10

MLB odds update live in real time.

📈 Astros vs. Blue Jays betting odds analysis

The total opened at 8.5 (-120) last night and this morning, but it quickly shifted to 9 (-110) with bets pouring in on the Over at most of the best sports betting apps. If you're looking to get in on the action, act now before we potentially see this number shift to 9.5


🔢 Astros vs. Blue Jays stats

Season stats courtesy of baseball-reference.com.

Astros (78-67) Statistic (per game) Blue Jays (83-61)
4.2 Runs 5.0
8.68 Hits 9.2
.253 AVG .269
.401 SLG .432
.719 OPS .770
3.85 ERA 4.23
9.56 K/9 8.98
3.34 BB/9 2.95
176 HR given up 192

🚑 Astros vs. Blue Jays injuries


📺 Astros vs. Blue Jays game info

  • When: Wednesday, Sept. 10
  • First pitch: 7:07 p.m. ET 
  • Where: Rogers Centre, Toronto, Ontario
  • How to watch: MLBN, SN

💡 Expert MLB predictions today


❓Astros vs. Blue Jays FAQs

Who is favored to win Astros vs. Blue Jays?

The Blue Jays are the -142 betting favorite to beat the Astros at home tonight.

What is the run line for Astros vs. Blue Jays?

Toronto's -1.5 odds range from +145 to +150, while Houston's +1.5 odds are at -175 on the high end of the market.

What is the Over/Under for Astros vs. Blue Jays?

Most of the best sports betting sites are setting the total at 9 runs, and it's juiced to -105 for the Over and -115 for the Under.

What are the best bets for Astros vs. Blue Jays?

My Astros vs. Blue Jays best bets back the Over to cash and Vladdy Jr. to collect over 1.5 bases.

When is the Astros vs. Blue Jays game?

The Astros vs. Blue Jays first pitch is set for 7:07 p.m. ET, airing on MLBN and Sportsnet.

How do baseball odds work?

When betting on MLB, the run line shows how many runs the favorite needs to win by in order to cash the bet. For example, a favorite of -1.5 must win by two or more runs to cover the run line, while an underdog at +1.5 must win outright or lose by one run to cover the run line.

Moneyline odds represent the payout for picking the outright winner (+200 means a $100 bet wins $200, while -200 means a $200 bet wins $100). Over/Unders let you wager on whether the combined total of runs will be higher or lower than the set number.

You can determine the payouts and implied probabilities for any wager - or convert odds to different formats - with our odds converter.

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