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Colorado wide receiver Travis Hunter stiff arms Nebraska defensive back Tommi Hill. We're breaking down Colorado vs. Colorado State in our college football predictions for Week 3.
Colorado wide receiver Travis Hunter stiff arms Nebraska defensive back Tommi Hill. Photo by Dylan Widger via Imagn Images.

The first two weeks of the season have had a major impact on the college football championship odds.

Several AP Top 25 teams have already lost, and as we dive into our college football Week 3 odds and predictions, there could be even more upsets with this slate. 

Saturday has a few hidden gems, too, with multiple rivalry games. That includes Colorado vs. Colorado State as Shedeur Sanders and Travis Hunter look to boost their Heisman Trophy odds.

But of all the matchups, ESPN College GameDay is headed to Columbia, S.C. with LSU a 7-point favorite at our college football betting sites against South Carolina.

College football picks & predictions Week 3

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Don't miss the rest of our Week 3 college football picks.

College football odds for Saturday

UTSA vs. Texas odds

Prediction: Jaydon Blue Under 81.5 rushing yards (-115 via bet365) ⭐⭐⭐⭐

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Pick made by Mike Spector.

  • When: Saturday, Sept. 14 (7 p.m. ET)
  • Where: DKR-Texas Memorial Stadium, Austin, Texas
  • How to watch: ESPN
  • Moneyline: OFF
  • Spread: UTSA +35 (-108) | Texas -35 (-112)
  • Total: 53.5 (-112/-108)

Georgia vs. Kentucky odds

Prediction: Brock Vandagriff Under 120.5 passing yards (-115 via bet365) ⭐⭐⭐⭐

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Pick made by Brenden Schaeffer.

  • When: Saturday, Sept. 14 (7:30 p.m. ET)
  • Where: Kroger Field, Lexington, Ky.
  • How to watch: ABC
  • Moneyline: Georgia (-3600) | Kentucky (+1500)
  • Spread: Georgia -24 (-110)| Kentucky +24 (-110)
  • Total: 45 (-108/-112)

Colorado vs. Colorado State odds

Prediction: Justin Marshall 70+ rushing yards (-105 via DraftKings) ⭐⭐⭐⭐

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Pick made by Mike Spector.

  • When: Saturday, Sept. 14 (7:30 p.m. ET)
  • Where: Canvas Stadium, Fort Collins, Colo.
  • How to watch: CBS
  • Moneyline: Colorado (-310) | Colorado State (+250)
  • Spread: Colorado -7.5 (-110) | Colorado State +7.5 (-110)
  • Total: 58.5 (-108/-112)

San Diego State vs. California odds

Prediction: Marquez Cooper Over 61.5 rushing yards (-114 via FanDuel) ⭐⭐⭐

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Pick made by Phil Wood.

  • When: Saturday, Sept. 14 (10:30 p.m. ET)
  • Where: California Memorial Stadium, Berkeley, Calif.
  • How to watch: ESPN
  • Moneyline: San Diego State (+750) | California (-1200)
  • Spread: San Diego State +18.5 (-108) | California -18.5 (-112)
  • Total: 47.5 (-112/-108)

College football picks roundup: Week 3

College football betting odds pages

Here are our best college football betting sites:

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