College Football Predictions Week 1: Picks & Odds for Marquee Games

After four games in Week 0, college football is back in full force with the Week 1 slate having a plethora of games.

Rob Paul

Last updated: September 2, 2024 12:51 PM EDT • 4 min read

Florida State quarterback DJ Uiagalelei passes the ball against Georgia Tech. The Seminoles are among the teams highlighted in our college football predictions for Week 1. — Florida State quarterback DJ Uiagalelei passes the ball against Georgia Tech. Photo by Tom Maher/INPHO/USA TODAY Sports via Imagn.

College football is back in full force with games from Thursday through Monday that are sure to shake up the college football championship odds.

With over 15 marquee matchups, there's a plethora of college football predictions for Week 1 to be made with the top college football betting sites.

But the biggest game of Week 1 gets the Saturday slate underway with Clemson and Georgia playing at Mercedes-Benz Stadium. The winner will get a massive boost to their College Football Playoff odds.

One of this week's hidden storylines will be the absence of Nick Saban on Alabama's sideline. Our C Jackson Cowart looked at how the world has changed since Saban wasn't the head coach at Alabama.

With several other games involving AP Top 25 programs, there's bound to be an upset or two.

College football picks & predictions Week 1

USC vs. LSU prediction

Boston College vs. Florida State prediction

Don't miss the rest of our Week 1 college football picks.

College football predictions for Monday

Boston College vs. Florida State odds

Prediction: Over 49.5 (-110 via FanDuel) ⭐⭐⭐⭐

Pick made by Rob Paul.

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When: Monday, Sept. 2 (7:30 p.m. ET)
Where: Doak Campbell Stadium (Tallahassee, Fla.)
How to watch: ESPN
Moneyline: Boston College (+490) | Florida State (-675)
Spread: Boston College +15.5 (-110) | Florida State -15.5 (-110)
Total: 50 (-110/-110)

Can Florida State win in 2024-25 despite the loss to Georgia Tech in Week 0? Definitely, but the Seminoles need a huge bounce-back game at home against Boston College. For as fun as Eagles' QB Thomas Castellanos is, the Seminoles should blow them out by three touchdowns. Bill O'Brien is getting far too much respect from the line in his first game as a college head coach in a decade.

College football picks roundup: Week 1

College football betting odds pages

College football championship odds	College football win totals	Big Ten championship odds	Mountain West championship odds
Heisman Trophy Odds	FCS Championship odds	Big 12 championship odds	MAC championship odds
College Football Playoff Odds	SEC championship odds	ACC championship odds	College bowl game odds

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Written By:
Rob Paul

Rob is a Publishing Editor at Sportsbook Review. He’s been with the team since early 2024, with this being his first full-time role in the sports betting industry. Before joining SportsbookReview.com, he contributed to various sports outlets, including FanSided and Pro Football Network. During that period, he spent five years working full-time as a local community journalist, after attending Durham College for journalism and Wilfrid Laurier University for history. He previously hosted an NFL draft and college football-focused podcast where he had the opportunity to interact with future NFL players such as Maxx Crosby and Quinn Meinerz. Rob has spent multiple years working as a freelance podcast producer for numerous sports-related podcasts while making guest appearances on several college football shows. He’s also made guest appearances on SportsTalk Mississippi on several occasions to talk all things NFL draft. Rob values the way sports betting acts as a catalyst for telling stories and growing interest in certain sports, particularly FCS football, WNBA, and mid-major college basketball. He’s always been drawn to the more obscure teams and conferences in major college sports, but most of all, Rob loves using stats to find the best player props to back.