College Football Expert Picks Week 6: Top CFB Predictions This Week
With a schedule full of Big Ten and SEC matchups, we're making our Week 6 college football expert picks.
- Oregon looks to reignite its college football championship odds against a struggling Michigan State program
- A College Football Playoff odds contender, Missouri has a chance at its first quality win of the season against a surging Texas A&M team
- Despite his Heisman Trophy odds taking a hit last week, Ole Miss QB Jaxson Dart can get back on track against South Carolina
As part of our Week 6 college football predictions, our experts break down their top picks for the best games this weekend. Shane Jackson continues offering up his best bets with his college football Week 6 player prop picks.
Mike Spector also offers his Week 6 college football predictions & best bets Week 6, which focus in on some of the less heralded matchups on the board.
College football expert picks for Week 6
College football odds as of Thursday and subject to change. See all of our college football picks for more on this week's top matchups.
| Rob Paul | C Jackson Cowart | |
|---|---|---|
| Michigan State vs. Oregon | Aidan Chiles 2+ interceptions (+230 via bet365) | Oregon -23.5 (-110 via BetMGM) |
| Missouri vs. Texas A&M | Luther Burden Over 69.5 receiving yards (-115 via Caesars) | Missouri +2.5 (-110 via DraftKings) |
| Iowa vs. Ohio State | Will Howard Under 247.5 passing yards (-114 via FanDuel) | Under 45.5 (-110 via BetMGM) |
| Auburn vs. Georgia | Trevor Etienne Over 85.5 rushing yards (-109 via Caesars) | Georgia -22 (-112 via DraftKings) |
| Ole Miss vs. South Carolina | Tre Harris Over 93.5 receiving yards (-115 via bet365) | Under 53.5 (-105 via BetMGM) |
| Clemson vs. Florida State | Phil Mafah Over 85.5 rushing yards (-114 via FanDuel) | Clemson -14.5 (-102 via FanDuel) |
Top picks for Week 6
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Michigan State vs. Oregon prediction: Aidan Chiles 2+ interceptions ⭐⭐⭐
The Spartans offense is one of the worst in the country - 111th in SP+ - and Chiles is a large reason why. He's thrown 2-plus interceptions in three of five games and is second in the country in both interceptions (8) and turnover-worthy plays (14), per PFF.
Meanwhile, Oregon's defense is eighth in EPA per dropback and has one of the most talented secondaries in the country. If the Ducks can pick Chiles off twice, a $10 bet pays a $23 profit.
The Ducks defense is a key reason why Mike Spector likes the home team in his Michigan State vs. Oregon prediction.
Best odds: +230 via bet365 | Implied probability: 30.30%
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Missouri vs. Texas A&M prediction: Missouri +2.5 ⭐⭐⭐⭐
I was high on Missouri coming into the season, and a close win two weeks ago against Vanderbilt doesn't deter me ahead of this matchup with Texas A&M, which narrowly beat Bowling Green and Arkansas in consecutive weeks.
With QB Conner Weigman a legitimate game-time decision for the Aggies and the Tigers' run defense profiling as one of the nation's best, I love the value at +2.5 with three of our best sportsbooks stuck at +2.
Brenden Schaeffer also sees value on the Tigers in his Missouri vs. Texas A&M prediction.
Best odds: -110 via DraftKings | Implied probability: 52.38%
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–– C Jackson Cowart (SBR | Twitter/X)
Iowa vs. Ohio State prediction: Will Howard Under 247.5 passing yards ⭐⭐⭐⭐
For as good as Ohio State's offense has been, Howard remains a question mark. He's thrown for Under 247.5 passing yards in two of four games and has made just four big-time throws with an ADOT of 7.4 yards.
Iowa's defense ranks first in SP+ and is allowing 210.8 passing yards per game. If the Hawkeyes hold Howard to fewer than 248 passing yards, a $10 bet pays an $8.77 profit.
This bet is featured in my favorite Iowa vs. Ohio State player props, which also focus on a star receiver for the Buckeyes.
Best odds: -114 via FanDuel | Implied probability: 53.27%
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Auburn vs. Georgia prediction: Georgia -22 ⭐⭐⭐⭐⭐
After last week's loss to Alabama, I would expect one heck of an effort from the preseason No. 1 team, which is still firmly in the playoff mix.
Meanwhile, Auburn is 0-3 against power conference opponents and has lost eight straight trips to Athens by an average of 21.6 points. In its first road game of the season, I wouldn't expect much of a contest.
Phil Wood sees this contest similarly to how I do, which is why he's laying the points in his Auburn vs. Georgia prediction.
Best odds: -112 via DraftKings | Implied probability: 52.83%
–– C Jackson Cowart (SBR | Twitter/X)
Ole Miss vs. South Carolina prediction: Tre Harris Over 93.5 receiving yards ⭐⭐⭐⭐
Tre Harris leads the country in receiving yards by more than 150 yards (804) and even managed 176 yards in the loss to Kentucky. He's averaging the most yards per route run in the nation (5.62) and has topped 93.5 yards in every game this season.
In its most recent SEC game, South Carolina gave up 285 passing yards, and it has allowed 94-plus receiving yards to a receiver in two of four games. If Harris hits that number, a $10 bet pays an $8.70 profit.
Best odds: -115 via bet365 | Implied probability: 53.49%
Clemson vs. Florida State prediction: Clemson -14.5 ⭐⭐⭐⭐⭐
For as bad as the Seminoles have looked through five games - they're 1-4 after last week's 42-16 loss to SMU - it could get even worse amid a rash of injuries to key starters.
Backup QB Brock Glenn will make his first start of the season on Saturday against Clemson, which is coming off three straight wins by 24 points or more. While most books are moving this toward -15, FanDuel is headed in the opposite direction with the best odds on the market.
Best odds: -102 via FanDuel | Implied probability: 50.50%
–– C Jackson Cowart (SBR | Twitter/X)
College football betting odds pages
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