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Miami Hurricanes quarterback Cam Ward (1) celebrates as we offer our college football Week 6 predictions.
Miami Hurricanes quarterback Cam Ward celebrates against the Virginia Tech Hokies. Photo by Sam Navarro / Imagn Images.

After the biggest week of the college football season so far, our college football Week 6 predictions feature just one ranked matchup but a whole host of tricky conference matchups for top teams.

The top game on Saturday kicks off at noon ET when Missouri faces Texas A&M in a matchup between college football championship odds contenders from the SEC.

Later in the day, Michigan faces Washington rematch of last year's title game as the Wolverines look to keep their College Football Playoff odds alive for another week. That contest kicks off at 7:30 p.m. ET on NBC.

Saturday's action wraps with Heisman Trophy odds contender Cam Ward and eighth-ranked Miami traveling to face California at 10:30 p.m. ET in their first clash as ACC foes.

College football picks & predictions Week 6

Our NEW college football player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

Don't miss the rest of our Week 6 college football picks.

College football odds for Saturday

College football odds via DraftKings and subject to change. Follow the latest college football scores for line history and matchup info.

Michigan vs. Washington odds

Prediction: Washington -1.5 (-108 via FanDuel) ⭐⭐⭐⭐

Pick made by Brenden Schaeffer

  • When: Saturday, Oct. 5 (7:30 p.m. ET)
  • Where: Alaska Airlines Field at Husky Stadium (Seattle)
  • How to watch: NBC
  • Moneyline: Michigan +115 | Washington -140
  • Spread: Michigan +2.5 (-105) | Washington -2.5 (-115)
  • Total: 40.5 (-110/-110)

Miami vs. California odds

Prediction: California +10.5 (-105 via Caesars) vs. Miami ⭐⭐⭐⭐

Pick made by Mike Spector

  • When: Saturday, Oct. 5 (10:30 p.m. ET)
  • Where: California Memorial Stadium (Berkeley, Calif.)
  • How to watch: ESPN
  • Moneyline: Miami -375 | California +295
  • Spread: Miami -10 (-112) | California +10 (-108)
  • Total: 54.5 (-112/-108)

College football picks roundup: Week 6

College football betting odds pages

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