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Kansas Jayhawks quarterback Jalon Daniels looks to fire a pass during the third quarter as we offer our best Big 12 bets for Week 6.
Kansas Jayhawks quarterback Jalon Daniels looks to fire a pass during the third quarter. Photo by © Evert Nelson/The Capital-Journal/USA TODAY NETWORK via Imagn Images

Our Big 12 predictions for Week 6 identify the best betting angles for a small slate of games.

There are only four conference matchups on Saturday, starting with a battle between Oklahoma State and West Virginia. Kansas’ trip to Arizona State will highlight a trio of evening games, which includes Baylor vs. Iowa State and Texas Tech vs. Arizona.

That doesn't include tonight's Big 12 matchup, which we broke down in our Houston vs. TCU prediction.

As part of our college football Week 6 predictions, here are my favorite ways to attack this week’s Big 12 schedule.

Big 12 best bets: Week 6

College football odds as of Thursday and subject to change. Track the college football scores for the latest line movement and matchup info.

Best Big 12 predictions this week

College football picks made Thursday; odds subject to change. Our NEW college football player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

Oklahoma State first-half ML (-135) ⭐⭐⭐⭐

The -135 betting line feels like the buy point on Mike Gundy’s Cowboys, who entered the year with conference championship aspirations after reaching the Big 12 title game last season.

Oklahoma State (3-2) has lost back-to-back games to Utah and Kansas State, two of the top contenders in the league. Last week, ahead of its 42-20 victory over OSU, Kansas State was my favorite bet.

But this is a get-right spot for the Cowboys’ offense.

West Virginia’s defense ranks 118th in the country in dropback success rate. College Football Insiders projects a 4.5-point margin between these two teams, suggesting value on Oklahoma State -3.

I prefer the first-half moneyline, especially since some of our best sportsbooks charge as much as -150 for this wager. A winning $10 bet will profit $7.41. 

Best odds: -135 via Caesars | Implied probability: 57.45%

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Arizona State ML (-135) ⭐⭐⭐⭐⭐

Fool me once; shame on you. Fool me twice, and I’m an idiot.

OK, that’s not how the expression goes, but I’ve certainly learned my lesson after betting KU’s moneyline in back-to-back weeks. The Jayhawks (1-4) are in trouble after starting the season ranked No. 22 in the AP preseason poll. 

The drop-off from Andy Kotelnicki to Jeff Grimes as offensive coordinator has been palpable.

Arizona State, meanwhile, is 3-1 in its first season in the Big 12 and coming off a bye. This will be KU’s first road trip out West in a new-look conference, and we saw how a similar trip went for Kansas State (against BYU) two weeks ago.

The market has moved this line in ASU’s favor since opening at -120, but this -135 price tag is still a value compared to BetMGM’s -145 odds.

Best odds: -135 via DraftKings | Implied probability: 57.45%

Jalon Daniels long completion Under 37.5 (-115) ⭐⭐⭐⭐⭐

The most concerning aspect of KU’s offense is the play of quarterback Jalon Daniels. He was once considered one of the best deep-ball passers in the league by PFF’s grading system, but that is no longer the case.

Per PFF, Daniels is 4-for-23 on passes of 20-plus yards this season, and he hasn’t completed a pass longer than 36 yards against an FBS foe this fall.

Take advantage of our best prop betting sites for offering this market. The Under is playable at 36.5 or better.

Best odds: -115 via bet365 | Implied probability: 53.49%

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