Giants vs. Patriots Predictions & Best Bets for Monday Night Football Tonight

The final game of NFL Week 13 kicks off shortly when the New England Patriots (10-2) host the New York Giants (2-10) on Monday Night Football (8:15 p.m. ET, ESPN) from Gillette Stadium in Foxborough, Mass. We've gathered all of our Giants vs. Patriots predictions and best bets for this MNF clash to wrap up our NFL Week 13 predictions.

Giants vs. Patriots predictions & best bets: Monday Night Football

See all of our NFL picks for every game based on the latest NFL odds.

Giants vs. Patriots prediction

Our NFL expert Gary Pearson has been on the Patriots all season long, so it's noteworthy that he's fading the NFL's hottest team and backing the Giants to not only cover the spread but pull off the outright upset and end New England's nine-game win streak.

Here's an excerpt from his Giants vs. Patriots prediction on why he's taking the Giants to cover the spread (and win outright) on Monday Night Football:

"While the Patriots have won a league-best nine in a row, they won three of four by six points or fewer, covering twice. Mike Vrabel's team failed to cover last week in Cincinnati despite facing an injury-riddled Bengals team that was without Trey Hendrickson, Ja'Marr Chase, and, at least for most of the fourth quarter, Tee Higgins."

Our Giants vs. Patriots AI predictions also expect this one to fall within the number in favor of New York, which could benefit from adverse weather conditions that suppress scoring and keep this game close to the end. We break that down further in our Giants vs. Patriots weather report.

Giants vs. Patriots player props

Pearson also dove into the player props market to find the best prop bets for Monday Night Football, and he has his eyes on receivers Isaiah Hodgins and Mack Hollins to make a surprise impact tonight for their respective sides.

Here's an excerpt from his Giants vs. Patriots player props on why he's backing Hodgins to finish with more than 20 receiving yards as his lone five-star bet tonight:

"Hodgins easily exceeded the 20.5-yard threshold in his only two games of the season thus far, accounting for 57 yards against Green Bay and 42 in Detroit versus the Lions. Tonight will mark the first time Hodgins and Dart will play together, but I expect the rookie QB to have taken note of Jameis Winston's success throwing to the 27-year-old. Fantasy Pros expects Hodgins to finish with 30.2 receiving yards."

Our NFL expert Dustin Saracini is also breaking down the outlook for both quarterbacks tonight with his best Drake Maye player props for the Patriots QB and his best Jaxson Dart player props for the Giants rookie.

Giants vs. Patriots anytime TD pick

Our NFL expert Esten McLaren has been money this year with his anytime TD picks in prime time, and he's targeting three players to reach this end zone tonight all with +220 odds or more - including a five-star bet at +250 odds to score on Monday Night Football.

Here's an excerpt from his anytime touchdown scorer predictions on why he's backing Patriots QB Drake Maye to find pay dirt tonight against the Giants:

"Maye is very much alive in the NFL MVP odds race after Matthew Stafford's stinker (two interceptions in a loss to the Carolina Panthers) yesterday. It's very fortunate for Maye that subpar effort from Stafford came right before his prime-time appearance, and he could take over as the MVP betting favorite with a big performance tonight at home with MVP chants likely to rain down. Maye has two rushing touchdowns this season while accumulating 307 yards on 75 rushing attempts. The Giants have given up four rushing touchdowns to opposing quarterbacks, and could help turn the MVP race in Maye's favor."

As McLaren alluded to, Maye could take over as the MVP favorite with a big performance at home tonight. We break down that race even further with a look at the latest Drake Maye MVP odds ahead of the Week 13 finale.

Giants vs. Patriots first TD pick

Our NFL expert Sean Tomlinson came oh-so-close to cashing his first TD bet last night on Courtland Sutton, which would have paid out at +850 odds. He's looking for more value bets tonight as he offers his three best picks to score the opening touchdown.

Here's an excerpt from his first touchdown scorer predictions on why TreVeyon Henderson is the best bet to score the first touchdown on Monday Night Football:

"The Giants field the league's worst run defense while allowing 157.2 rushing yards per game. They've given up the second-most yards to running backs and are tied for the third-most touchdowns allowed (12). Now that unit is tasked with slowing Henderson, who has scored five times across his last three games. He's still getting the bulk of the work even with Rhamondre Stevenson back from injury too, as last game Henderson received 21 touches with Stevenson at only seven."

You can follow all of our NFL touchdown props every week ahead of prime time.

Giants vs. Patriots same-game parlay

Our NFL expert Brenden Schaeffer is looking for the big payday tonight with his Giants vs. Patriots SGP, which pays out at +675 if all three legs hit tonight on Monday Night Football.

Here's an excerpt from his Giants vs. Patriots same-game parlay on why he's leaning in on Henderson, who is featured in two of his three legs tonight:

"We’re doubling down on Henderson because combining his two props with Giants +7.5 provides a strong negative correlation boost to our SGP odds at DraftKings. The Giants have allowed 12 rushing touchdowns to opposing running backs this season (tied for 4th-most in the NFL), and they've also surrendered four receiving scores to RBs (tied for second-most). Henderson has scored five touchdowns over his past three games."

How to watch Monday Night Football: Giants vs. Patriots

• Date: Monday, Dec. 1
• Kickoff: 8:15 p.m. ET
• Location: Gillette Stadium (Foxborough, Mass.)
• TV: ESPN