49ers vs. Chargers Prediction, Picks & Best Bets: NFL Preseason Week 2 Odds
The San Francisco 49ers and Los Angeles Chargers meet in Week 2 of the NFL preseason, ahead of their December regular-season matchup. My 49ers vs. Chargers prediction looks to exploit an injured San Francisco side with a murky backup quarterback situation.
Kickoff from SoFi Stadium in Inglewood, Calif., is set for 10 p.m. ET (NFL Network), with the Chargers priced as a 1.5-point betting favorite.
π 49ers vs. Chargers prediction: NFL preseason Week 2
See the latest NFL odds and our experts' NFL picks for every game this season.
| π° Pick | βοΈ Units | π§ Why I bet this |
|---|---|---|
| Chargers -1.5 (-110 via DraftKings) | 0.6u β 0.55u | 49ers could be without their three top QBs. |
| Under 38.5 (-108 via DraftKings) | 0.4u β 0.37u | SF could struggle to score amid offensive depth issues. |
Total wagered: 1 unit | Max profit: 0.92 units
π° 49ers vs. Chargers best bet
Chargers -1.5 (-110)
Preseason quarterback depth is critical to my evaluation, especially when inexperienced reserves dominate the snap count. The 49ers' backup situation is bleak if QB2 Mac Jones misses another week. Kurtis Rourke is unlikely to play versus the Chargers after a rib injury sent him to the hospital last week, while fourth-stringer Adrian Martinez completed less than 50% of his passes in relief of Rourke.
Meanwhile, Los Angeles' backups led five scoring drives in their Week 1 preseason victory. I bet the Chargers to win and cover the 1.5-point spread at DraftKings' -110 odds.
Score prediction: Chargers 19, 49ers 16
π 49ers vs. Chargers same-game parlay
I'm combining my best bets for the matchup into a 2-leg parlay at +268 odds at DraftKings. The 49ers' offensive cupboard is presently barren, especially at the quarterback position, resulting in what I believe will be a low-scoring Chargers victory in Week 2 of the preseason. That was the recipe for L.A. in its win a week ago.
💵 49ers vs. Chargers SGP picks
- Chargers -1.5
- Under 38.5
Best odds: +268 via DraftKings (0.2u β 0.54u)
π΅ My betting record for NFL picks
All NFL preseason picks, including SGPs, have been tracked since Aug. 7.
| Bet type | Record | Net profit | ROI |
|---|---|---|---|
| Overall | 6-5 | +0.57 units β | 14.25% β |
| Game picks | 5-5 | +0.32 units β | 8.89% β |
| Player props | 1-0 | +0.25 units β | 62.5% β |
π‘ How I'm betting 49ers vs. Chargers: NFL preseason strategy
Follow all of our NFL analysis and betting advice for the 2026 NFL season.
Itβs important not to get carried away with your bet sizes in the preseason. Iβm only betting one unit total across my two favorite wagers for 49ers vs. Chargers because there is so much uncertainty in the preseason surrounding player snap counts, play-calling, and other variables. My most confident play (Chargers -1.5) received the highest wager at 0.6 units, slightly above my other best bet. Bankroll management is crucial in sports betting, so be smart with yours.
π 49ers vs. Chargers odds: NFL preseason Week 2
Our live 49ers vs. Chargers odds update in real time.
π 49ers vs. Chargers latest injuries
πΊ How to watch 49ers vs. Chargers: NFL preseason Week 2
- Date: Thursday, Aug. 20
- Kickoff: 10 p.m. ET
- Location: SoFi Stadium (Inglewood, Calif.)
- TV: NFL Network
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