49ers vs. Raiders Odds, Picks, Predictions Week 17: Niners Celebrate Purdy Season in Las Vegas

Get our best 49ers vs. Raiders NFL odds, picks and predictions for Week 17!

Last Updated: January 1, 2023 8:12 AM EST • 3 minute read

The Las Vegas Raiders have moved on from quarterback Derek Carr, and in Week 17 they face a San Francisco 49ers squad that's in fine form. We break down the NFL odds and offer our top 49ers-Raiders NFL picks.

The 49ers are the NFL’s juggernaut at the moment, winning eight consecutive games. They’re the only team in the Super Bowl era to win eight straight games in a single season while holding their opponents to fewer than 80 rushing yards in each game.

The Raiders blew a fourth-quarter lead against the Pittsburgh Steelers on an emotional Christmas Eve night in the Steel City. Raiders QB Derek Carr threw three interceptions in the 13-10 loss and has been dropped for Jarrett Stidham.

Here is our best 49ers vs. Raiders NFL pick for Week 17 (odds via DraftKings Sportsbook; pick confidence based on a 1-to-5-star scale).

Check out our NFL best bets and all of our top NFL picks for Week 17!

49ers vs. Raiders Game Info

Date: Sunday, Jan. 1, 4:05 p.m. ET
TV: FOX
Location: Allegiant Stadium, Las Vegas, NV
Weather: Indoors

49ers vs. Raiders Odds

49ers vs. Raiders Odds Analysis

The 49ers opened as 4.5-point favorites, but that line has had a huge shift to 9.5 points after news that Jarrett Stidham would be starting at quarterback for the Raiders. Well over half the cash (55%) is on the Niners, while 84% of the tickets are also backing San Francisco.

The total opened at 44.5 but has dropped to 41 with some of our Best NFL Betting Sites. There’s not much confidence in the Raiders’ ability to score against this dominant Niners defense, with 77% of the cash on the Under, while 60% of the tickets are backing the Over.

Editor's note: Hey Ohio! Welcome to legal sports betting. Check out the best sites for Ohio sports betting and the best Ohio sportsbook promos!

49ers vs. Raiders Pick

49ers team total Over 26.5⭐⭐⭐⭐⭐

San Francisco has scored over 30 points in five of its last eight games. The Raiders' defense had six interceptions last season and has just five so far this season. No NFL team has had six or fewer interceptions in back-to-back seasons but 49ers quarterback, Brock Purdy can’t seem to do anything wrong. He’s one of three QBs in the Super Bowl era to have a passer rating of 120.0 or better over his first three career starts, along with Patrick Mahomes (130.1) and Kurt Warner (125.0).

Niners tight end George Kittle has 213 total receiving yards and four touchdowns in his last two games, while running back Christian McCaffrey has scored five total touchdowns across his last four outings. You can rely on this 49ers team to score.

49ers vs. Raiders Best Odds

Caesars (-110)

DraftKings	FanDuel	BetMGM	Caesars	PointsBet
25.5	25.5	25.5	25.5	26.5
-115	-112	-115	-110	-105

Barring any severe blips, the 49ers should win this game. Stidham commanding this Raiders offense with Nick Bosa and company breathing down his neck doesn’t fill you with confidence. There’s no value in betting the moneyline, with PointsBet offering the best odds of -450.

The 10-point spread feels like too much, regardless of how good San Francisco is. The Niners are -110 to cover at all the main sportsbooks. It’s worth pointing out that the Raiders' last eight games were each decided by one score, the second-longest streak in team history.

While most sportsbooks have settled on a team total of 25.5 for the 49ers, the highest value is with Caesars, priced at a standard -110. That is the best return for a play on a team that’s seemingly scoring for fun as it chases the No. 2 seed in the NFC.

49ers-Raiders pick made 12/29/2022 at 3:28 a.m. ET.

Here are our Best NFL Betting Sites:

FanDuel: Get a $1,000 No-Sweat Free Bet | Read our FanDuel Review
Caesars: Earn a Free Bet of Up to $1,250 | Read our Caesars Review
DraftKings: Get a 20% Deposit Match up to $1,000 | Read our DraftKings Review
PointsBet: Earn Five Free Bets of Up to $100 Each | Read our PointsBet Review
BetMGM: Get a Free Bet of Up to $1,000 | Read our BetMGM Review

* Bonuses not applicable in Ontario.

Best Online Sportsbooks | Best U.S. Sportsbook Promos

Written by:
Anthony Wootton

Anthony Wootton has worked in the sports industry for more than 20 years. He’s reported on Premier League games for BBC radio and continues to cover the league, as well as other high-profile soccer competitions such as the UEFA Champions League. He is a founding member of the NFL Writers Network with NFL Europe, having covered every NFL London game since 2014 and multiple Super Bowls. Anthony has also reported on the Germany games in Munich and Frankfurt. His book, "The Greatest American Football Story That Has Never Been Told", has been an Amazon bestseller for American Football and Sports History publications. He is a member of the Professional Football Researchers Association. Anthony started writing for betting companies in 2018, working with some of the world’s largest gambling sites. He is an avid bettor on soccer and football, using multiple apps as he targets the best value on props and plays. Anthony is the host of the "TransAtlantic Sports Show" podcast and runs a weekly parlay feature on his YouTube channel throughout the NFL season. He has appeared on leading international podcasts such as the BBC World Service’s Sportshour, the Nat Coombs Show, and the Irish NFL Show. Anthony holds a bachelor’s degree in media from Sheffield Hallam University.