South Carolina vs. Indiana Prediction, Odds & Preview: Best Picks for Women's March Madness

The No. 1 seed South Carolina Gamecocks (31-3) meet the No. 9 seed Indiana Hoosiers (20-12) in the women's NCAA Tournament first round on Sunday at 3 p.m. ET (ABC) at Colonial Life Arena in Columbia, SC.

The Gamecocks are 22.5-point favorites to advance in the Birmingham 2 Region of the women's March Madness bracket.

We explain why the Hoosiers may have a chance to keep this closer than our best sportsbooks expect in the South Carolina vs. Indiana prediction, odds, and preview as part of our women's March Madness predictions.

🏀 South Carolina vs. Indiana prediction & picks for Sunday

Here are my best South Carolina vs. Indiana predictions for the first round of the NCAA Tournament; use our parlay calculator to get the best odds for any same-game parlay:

✅ Against the spread pick: Indiana +22.5 (-102 via BetMGM) vs. Indiana ⭐⭐⭐
🔥 Best team prop bet: Indiana Over 57.5 points (+100 via DraftKings) ⭐⭐⭐
🎯 Exact score prediction: South Carolina 80, Indiana 63 (+19000 via DraftKings)

👉 Want more March Madness action? Check out the rest of our college basketball picks for both the men's and women's NCAA tournament.

🏆 Best South Carolina vs. Indiana pick, player prop bet & score prediction

Our NEW college basketball player prop odds tool can help you find the best odds for any March Madness market across legal sportsbooks in your area!

✅ Indiana to cover the spread: +22.5 ⭐⭐⭐

This is only a three-star play because the women's March Madness odds co-favorites can blow out any team in the country. However, the Hoosiers could surprise a lot of bettors and keep this much closer than expected.

The Hoosiers are playing their best basketball of the season right now. They lost by just five to the USC Trojans in their final game before the NCAA Tournament. It was their second single-digit loss to the Trojans this season. In late February, they also knocked off the Ohio State Buckeyes, and they haven’t lost a game by more than 14 since Nov. 25.

At 31-3, there is no doubt the Gamecocks are one of the best teams in the country, but they won five consecutive games by 21 or fewer points before the NCAA Tournament.

Though they had an impressive 19-point win over the Texas Longhorns in the SEC championship, they had lost to that same team earlier in the season. It's a risky play, but I’ll take the hot Hoosiers to avoid getting blown out.

📊 Best odds: -102 via BetMGM ($10 to win $9.80)

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🔥 Indiana Over 57.5 points ⭐⭐⭐

The Hoosiers have scored at least 58 points in 11 of their last 12 games. During that stretch, they played four ranked opponents, including the Trojans. The Gamecocks are allowing 57.5 points per game, so even though the Hoosiers are averaging 70.5 points per contest, oddsmakers like the Gamecocks’ defense to dominate.

The Hoosiers had a miserable 39-point performance against the North Carolina Tar Heels earlier this season. However, it was played so long ago that I won’t let it overshadow what this team has done lately.

While the Gamecocks have held back-to-back opponents to 48 or fewer points, they allowed at least 59 in four consecutive games beforehand. During that span, the Sooners managed to drop 75.

📊 Best odds: +100 via DraftKings ($10 to win $10)

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🎯 Score prediction: South Carolina 80, Indiana 63

I’ve been singing the Hoosiers’ praises; now it’s time to give the Gamecocks some love. While the Hoosiers have played well of late and will keep this game within 20 points, I don’t expect it to be a very competitive contest. The Gamecocks have won seven games in a row, and all those victories have been by double digits.

The Hoosiers will score enough to keep this entertaining early, but the Gamecocks will assert their dominance as the game goes on. The Gamecocks have scored at least 75 in seven of their last eight games, and I expect it to become eight of nine today.

📊 Best odds: +19000 via DraftKings ($10 to win $1,900)

🤖 South Carolina vs. Indiana AI prediction

For entertainment purposes, we asked ChatGPT to analyze historical trends and live NCAA Tournament stats before predicting the winner and exact score for South Carolina vs. Indiana. Our AI prediction projects a final score of South Carolina 75, Indiana 63.

🖥️ AI score prediction: South Carolina 75, Indiana 63

• The Gamecocks’ defense is likely to hold Indiana in check and can capitalize on key moments.
• South Carolina has the edge in nearly every category: rebounding, defense, and overall depth.
• The Hoosiers are a very strong defensive team but may not match South Carolina’s physicality and pressure on the ball.

🤔 Betting takeaway: ChatGPT's AI prediction would mean Indiana covering the spread (+22.5) and a total of Under 136.5 points. ChatGPT is not a dedicated sports betting model, but it can identify data that March Madness bettors might overlook.

📊 South Carolina vs. Indiana odds

Follow the latest women's March Madness odds for the NCAA Tournament.

While South Carolina vs. Indiana isn't one of the most bet games on the docket today, the public is loving the Gamecocks. South Carolina is the most bet team to cover the spread (-22.5) at BetMGM. The Gamecocks are unsurprisingly receiving 84% of the bets and 88% of the handle at our best live betting sites.

🔢 South Carolina vs. Indiana opening odds

• Spread: South Carolina -22.5 (-110) | Indiana +22.5 (-110)
• Moneyline: South Carolina -10000 | Indiana +3000
• Over/Under: Over 136.5 (-110) | Under 136.5 (-110)

📺 How to watch South Carolina vs. Indiana: Women's March Madness

📅 Date: Sunday, March 23
🕗 Time: 3 p.m. ET
📍 Location: Colonial Life Arena (Columbia, SC)
📺 TV: ABC
💻 Streaming: March Madness Live

💰 March Madness betting odds pages

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