Ohio State vs. Penn State Early Picks, Predictions & Odds Week 10

In the most significant game of the Week 10 slate, Ohio State takes on Penn State at Beaver Stadium in a matchup between two top four teams.

Rob Paul

Last Updated: October 28, 2024 2:13 PM EDT • 5 minute read

Penn State defensive end Abdul Carter celebrates after a defensive stop against West Virginia. We're backing the Nittany Lions in our Ohio State vs. Penn State early leans. — Penn State defensive end Abdul Carter celebrates after a defensive stop against West Virginia. Photo by Ben Queen via Imagn Images.

Ryan Day gets a chance at redemption when he leads Ohio State against Penn State at Beaver Stadium in University Park, Pa. on Saturday at noon ET (FOX) in a clash of two top-four teams.

With the Nittany Lions a 4-point underdog, our Ohio State vs. Penn State early picks think James Franklin's team is the program to back
Both schools are among the five programs with shorter than 15/1 college football championship odds
Despite the teams being ranked No. 3 and No. 4, respectively, neither boasts a Heisman Trophy odds contender with odds shorter than 50/1

There's a lot of pressure on both programs in this Big Ten matchup since this is the best game of Week 10 between AP Top 25 teams, and the first College Football Playoff rankings coming out Nov. 5.

Now that we're closer to kickoff, Mike Spector has provided us with his Ohio State vs. Penn State prediction.

My early Ohio State vs. Penn State prediction

College football picks made Monday; odds subject to change. Our NEW college football player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

Prediction: Penn State +3.5

Best odds: -104 via FanDuel | Implied probability: 50.98%

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There's clearly a massive issue with Ohio State's offensive line after potential first-round left tackle Josh Simmons suffered a season-ending injury against Oregon. That's the key to this matchup.

Penn State boasts one of the nation's best defensive line trios in Abdul Carter, Zane Durant, and Dani Dennis-Sutton (if he plays). They've pushed the Nittany Lions to a No. 3 ranking in SP+ defensively.

Meanwhile, Ohio State could only muster 285 yards and 21 points against Nebraska in Week 9 because of offensive line issues. While I do think the Buckeyes win, they won't cover.

The health of Penn State QB Drew Allar will be key to the Nittany Lions covering. He exited late in the second quarter against Wisconsin last week. If Allar can't play, this line could move to Buckeyes -6. If that's the case, I'd take Ohio State to cover.

Assuming Allar plays, I have Ohio State winning this one 23-20.

Our Shane Jackson is eyeing Nittany Lions receiver Harrison Wallace III to go Over his receiver yardage prop as part of his college football Week 10 player prop picks.

Don't miss our guide for how to bet on college football or this week's best sportsbook promos.

Ohio State vs. Penn State live odds

See the college football odds from our best college football betting sites for every Week 10 game.

Moneyline

Ohio State best odds: -170 via FanDuel | Implied probability: 62.96%
Penn State best odds: +160 via bet365 | Implied probability: 38.46%

Our best sports betting sites don't differ much on the moneyline, with the Buckeyes sitting around -190 at most.

That's why this price at FanDuel (-170) is definitely the best to back, with a $10 winning bet leading to a $5.88 profit. Penn State is between +140 and +160, and I don't expect that to change unless Allar is ruled out.

Spread

Ohio State best odds: -4 (-110) via DraftKings
Penn State best odds: +3.5 (-104) via FanDuel

Most of our best NFL betting sites are featuring Ohio State as a 4-point favorite with -110 odds. FanDuel is the exception, with Penn State being +3.5 at -104.

Again, the line movement will depend on if Allar plays. SP+ projects a 25-24 Buckeyes win, while CFB Graphs forecasts a 23-22 win for the Buckeyes.

Over/Under

Over best odds: 47 (-110) via Caesars
Under best odds: 47.5 (-110) via BetMGM

There's a little more discrepancy with the game total in this matchup than with the spread. FanDuel is posting it lower at 46.5 (-114 Over, -106 Under) while BetMGM is offering 47.5 (-110 Over/Under).

Our other best NFL prop betting sites are all at 47 (-110 Over/Under). I'd take the Under on any of those numbers, with both defenses ranking in the top 16 in EPA per rush and dropback.

I don't expect the total to move below 46.5 at any of our best sportsbooks unless Allar is out.

How to watch Ohio State vs. Penn State

When: Saturday, Nov. 2
Kickoff: Noon ET
Where: Beaver Stadium (University Park, Pa.)
How to watch: FOX
Weather: 55 degrees, 20% chance of precipitation, wind 2 mph NE
Favorite: Ohio State -4 (-110 via bet365)

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Written by:
Rob Paul

Rob is a Publishing Editor at Sportsbook Review. He’s been with the team since early 2024, with this being his first full-time role in the sports betting industry. Before joining SportsbookReview.com, he contributed to various sports outlets, including FanSided and Pro Football Network. During that period, he spent five years working full-time as a local community journalist, after attending Durham College for journalism and Wilfrid Laurier University for history. He previously hosted an NFL draft and college football-focused podcast where he had the opportunity to interact with future NFL players such as Maxx Crosby and Quinn Meinerz. Rob has spent multiple years working as a freelance podcast producer for numerous sports-related podcasts while making guest appearances on several college football shows. He’s also made guest appearances on SportsTalk Mississippi on several occasions to talk all things NFL draft. Rob values the way sports betting acts as a catalyst for telling stories and growing interest in certain sports, particularly FCS football, WNBA, and mid-major college basketball. He’s always been drawn to the more obscure teams and conferences in major college sports, but most of all, Rob loves using stats to find the best player props to back.