Nebraska vs. Illinois Predictions, Picks & Odds Week 6: Defensive Struggle in Champaign?

Check out our best prediction for the Week 6 college football matchup between Nebraska and Illinois based on the best NCAAF odds.
Reduced Juice Sportsbooks

Defense should play a massive role in Friday night's Big Ten matchup as we make our Nebraska-Illinois prediction based on the best college football odds.

Nebraska (2-3) hasn’t found the mark in conference play to begin the campaign. The Huskers are searching for their first Big Ten win this year as they travel to face Illinois (2-3) on Friday night in Champaign.

Meanwhile, Illinois has had trouble gaining traction in the early going, and it looks to bounce back from a 44-19 defeat at the hands of Purdue last Saturday. Could this be a bit of a cagey affair?

To help fill out your college football predictions for Week 6, here is our best Nebraska vs. Illinois prediction and our college football picks (odds via our best college football betting sites; pick confidence based on a 1-to-5-star scale).

Nebraska vs. Illinois prediction

Under 43.5 (-115 via BetMGM) ⭐⭐⭐

Nebraska and Illinois don’t profile as robust offensive teams by any stretch of the imagination. The Illini rank 94th in the nation in scoring on a points-per-game basis, averaging 21.6 PPG. The Cornhuskers are even worse, scoring an average of 18.8 PPG (111th in FBS).

Given the relative inefficiencies of both offenses compared to both defenses, there’s no reason to believe the scoring expectations should change much for Friday night’s game. Nebraska’s offensive efficiency ranks outside the top 100 across FBS, but its adjusted defensive efficiency suggests a capable group, coming in at No. 49 overall. Offensively, Illinois similarly ranks better on the defensive side, as the Illini are 91st in adjusted offensive efficiency but 72nd in defensive efficiency. 

Though Illinois runs an offense that ranks 20th in the nation in seconds per play, Nebraska will look to turn the game into a slog with its 114th-ranked pace offensively as part of our college football predictions for Week 6. The notion that both offenses are less efficient than the defenses they’ll be opposing will contribute to the belief in a low-scoring affair.

Although Nebraska’s strength offensively is in the run game—an area where Illinois has statistically been weaker this season—the notion of Nebraska chewing up time of possession by running the ball with frequency should still contribute to keeping the total points down in the game. Therefore, we don’t view Nebraska running all over the Illini as a risk to keeping the total to the Under.

Up To $1,500 First Bet

Bonus bets will expire in 7 days. One new customer offer only. Additional terms and conditions apply.

Each product featured on our website has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.

Not intended for use in MA
Affiliate Disclosure:
Sportsbook Review may receive advertising commissions for visits to a sportsbook

Visit our Google News page and click "Follow" (⭐) for the latest odds, picks and news!  

Nebraska vs. Illinois best odds

Under 43.5 (-115 via BetMGM)

DraftKings FanDuel BetMGM Caesars bet365
Under 43 Under 43.5 Under 43.5 Under 43 Under 43
-110 -120 -115 -110 -110

DraftKings, Caesars, and bet365 provide identical odds and an identical line on this total at 43 with standard -110 odds. FanDuel and BetMGM list the total at a half-point higher at 43.5, but charge a premium to get the Under at that number.

FanDuel’s juice to -120 is not worth the squeeze compared to the more reasonable -115 odds on Under 43.5 at BetMGM. We recommend this Under as a four-star play at 43.5, and would play it as a three-star play down to 41.5.

Nebraska vs. Illinois odds

Nebraska vs. Illinois odds analysis

Illinois opened as a 3-point home favorite and has seen that number move to -3.5 across our best sports betting apps. Nearly 55% of point-spread wagers have been placed on Illinois.

The total opened at 44.5 and has dipped slightly to between 43 and 43.5 across our best sports betting sites. Despite this movement, 61% of wagers have come in on the Over.

Nebraska vs. Illinois game info

  • When: Friday, Oct. 6, 2023 at 8 p.m. ET
  • Where: Memorial Stadium, Champaign, IL
  • How to watch: FS1
  • Weather: 53 degrees, 20 mph winds, 25% chance of precipitation

Nebraska-Illinois prediction made Wednesday at 4 p.m. ET.

Kentucky bettors: Sports betting is here!

Kentucky sports betting launched on Sept. 28 - so sign up with the best Kentucky sportsbook promos now! And check out our list of the best Kentucky sports betting apps!

21+ and present in KY. Gambling Problem? Call 1-800-GAMBLER

College football betting odds pages

Check out our best college football betting sites:

(21+. Gambling Problem? Call 1-800-GAMBLER)
* Bonuses not applicable in Ontario.

Related pages