College Football AI Predictions Week 4: ATS Picks & Score Projections for Saturday

Our college football AI predictions include projected scores and box scores for the best Week 4 matchups.
College Football AI Predictions Week 4: ATS Picks & Score Projections for Saturday
Pictured: Oklahoma Sooners quarterback John Mateer (10) runs the ball against the Michigan Wolverines. Photo by Bryan Terry / The Oklahoman via Imagn Images.

Our college football AI predictions take aim at the best games for Week 4 - including three ranked matchups between top-25 teams and two other highly anticipated clashes as we dive into conference play.

We trained the latest and most advanced ChatGPT model to predict the top matchups every week while offering college football picks and score predictions for the rest of this week's premier slate - led by Texas Tech vs. Utah, Auburn vs. Oklahoma, and Illinois vs. Indiana.

Looking for our (human) expert picks? We have you covered with all of our college football predictions for Week 4.


🤖 College football AI predictions for Week 4

College football AI predictions and score projections via ChatGPT simulation model with ATS pick confidence based on a 1-to-5-star scale and latest college football odds.

Prediction ATS pick Confidence
Memphis 31, Arkansas 27 Memphis +7.5 ⭐⭐⭐
TCU 30, SMU 23 TCU -6.5 ⭐⭐⭐⭐
Utah 24, Texas Tech 20 Utah -3.5 ⭐⭐⭐
Clemson 35, Syracuse 23 Syracuse +17 ⭐⭐⭐
Oregon 41, Oregon State 17 Oregon State +34.5 ⭐⭐⭐⭐
Michigan 24, Nebraska 20 Michigan -1.5 ⭐⭐⭐
Notre Dame 34, Purdue 17 Purdue +25.5 ⭐⭐⭐⭐
Ole Miss 31, Tulane 27 Tulane +12.5 ⭐⭐⭐
UCF 33, North Carolina 27 North Carolina +7 ⭐⭐⭐
Oklahoma 31, Auburn 21 Oklahoma -6.5 ⭐⭐⭐⭐
Missouri 30, South Carolina 20 Missouri -9.5 ⭐⭐⭐⭐
Washington 38, Washington State 24 Washington State +19.5 ⭐⭐⭐
Miami 28, Florida 24 Florida +8.5 ⭐⭐⭐
Illinois 24, Indiana 23 Illinois +6.5 ⭐⭐⭐⭐
Baylor 28, Arizona State 23 Baylor -2.5 ⭐⭐⭐
Colorado 35, Wyoming 17 Colorado -13 ⭐⭐⭐⭐
USC 38, Michigan State 20 Michigan State +19.5 ⭐⭐⭐⭐
Sbr Bt B Lobby 1 K

🏈 Texas Tech vs. Utah prediction

College Football AI Predictions Week 4: ATS Picks & Score Projections for Saturday
Pictured: Utah Utes quarterback Devon Dampier (4) runs the ball against the Cal Poly Mustangs. Photo by Rob Gray / Imagn Images.

🚨 Texas Tech vs. Utah projected score

Team 1Q 2Q 3Q 4Q Final
Texas Tech 7 3 3 7 20
Utah 3 7 7 7 24

🔢 Utah projected stats

  • Passing leader: Devon Dampier - 19/29, 238 yards, 1 TD
  • Rushing leader: Wayshawn Parker - 17 rushes, 86 yards, 1 TD
  • Receiving leader: Ryan Davis - 6 receptions, 78 yards, 1 TD

🔢 Texas Tech projected stats

  • Passing leader: Behren Morton - 24/37, 277 yards, 2 TD, 1 INT
  • Rushing leader: Adam Hill - 13 rushes, 66 yards
  • Receiving leader: Coy Eakin - 6 receptions, 90 yards, 1 TD

🆚 Texas vs. Utah preview

Utah’s profile looks stable: a turnover-light start from Devon Dampier, a productive early season from Wayshawn Parker, and an experienced target in Ryan Davis give the Utes reliable answers on standard downs. At home, they’re well-positioned to control tempo, play the field-position game, and finish drives at a higher rate than they did a year ago.

Texas Tech still brings real punch through Behren Morton and a healthy Coy Eakin, but the Red Raiders are thinner at running back after Quinten Joyner’s season-ending injury and now lean on a three-headed backfield led by freshman Adam Hill. If Tech can’t generate early-down efficiency, Utah’s pass rush and crowd noise tilt the key third-down snaps.


🏈 Michigan vs. Nebraska prediction

College Football AI Predictions Week 4: ATS Picks & Score Projections for Saturday
Pictured: Michigan quarterback Bryce Underwood (19) runs for a first down against Central Michigan. Photo by Junfu Han / USA TODAY NETWORK via Imagn Images.

🚨 Michigan vs. Nebraska projected score

Team 1Q 2Q 3Q 4Q Final
Michigan 7 7 3 7 24
Nebraska 3 7 3 7 20

🔢 Michigan projected stats

  • Passing leader: Bryce Underwood - 18/29, 224 yards, 1 TD, 1 INT
  • Rushing leader: Justice Haynes - 22 rushes, 118 yards, 1 TD
  • Receiving leader: Donaven McCulley - 5 receptions, 81 yards

🔢 Nebraska projected stats

  • Passing leader: Dylan Raiola - 21/33, 248 yards, 1 TD, 1 INT
  • Rushing leader: Emmett Johnson - 19 rushes, 82 yards
  • Receiving leader: Dane Key - 7 receptions, 96 yards, 1 TD

🆚 Michigan vs. Nebraska preview

Memorial Stadium gives Nebraska a real lift, and Dylan Raiola’s early-season efficiency is undeniable. Still, the matchup tilts toward Michigan’s ground game: transfer back Justice Haynes has stacked 100-yard outings, and the Wolverines can lean into a run-first script to keep the freshman Bryce Underwood in manageable downs.

Nebraska’s defense has choked off passing attacks so far, but the Huskers have been more forgiving on the ground; if Emmett Johnson can’t keep pace on standard downs, Raiola is forced into tighter windows against a deeper front. In a field-position game with few explosives, our model gives Michigan a late red-zone edge and a one-score road win.


🏈 Auburn vs. Oklahoma prediction

College Football AI Predictions Week 4: ATS Picks & Score Projections for Saturday
Pictured: Oklahoma Sooners quarterback John Mateer (10) rushes against Temple Owls linebacker Ty Davis (10). Photo by Kyle Ross / Imagn Images.

🚨 Auburn vs. Oklahoma projected score

Team 1Q 2Q 3Q 4Q Final
Auburn 3 7 7 3 20
Oklahoma 7 10 3 7 27

🔢 Oklahoma projected stats

  • Passing leader: John Mateer - 22/34, 268 yards, 2 TD, 1 INT
  • Rushing leader: Jovantae Barnes - 15 rushes, 82 yards, 1 TD
  • Receiving leader: Deion Burks - 6 receptions, 88 yards, 1 TD

🔢 Auburn projected stats

  • Passing leader: Jackson Arnold - 21/33, 242 yards, 1 TD, 1 INT
  • Rushing leader: Jeremiah Cobb - 14 rushes, 71 yards, 1 TD
  • Receiving leader: Eric Singleton Jr. - 6 receptions, 79 yards, 1 TD

🆚 Auburn vs. Oklahoma preview

Oklahoma enters with a clear identity: an up-tempo, QB-forward attack under OC Ben Arbuckle, and a hot-handed John Mateer who’s thrust himself into the Heisman Trophy odds conversation. With a deep receiver room (Burks, Keontez Lewis, Isaiah Sategna) and a steady rotation at RB led by Jovantae Barnes, the Sooners project to sustain drives and finish enough red-zone trips at home in Norman.

Auburn’s best counter is balance and ball control around Jackson Arnold, with playmakers on the perimeter (Eric Singleton Jr., Cam Coleman) and a backfield that can share volume if Damari Alston’s workload fluctuates. The Tigers are dangerous - especially if they flip field position - but OU’s passing efficiency and crowd-aided third-down edge tilt a one-score game to the Sooners.


🏈 Florida vs. Miami prediction

College Football AI Predictions Week 4: ATS Picks & Score Projections for Saturday
Pictured: Miami Hurricanes quarterback Carson Beck (11) reacts against the South Florida Bulls. Photo by Sam Navarro / Imagn Images.

🚨 Florida vs. Miami projected score

Team 1Q 2Q 3Q 4Q Final
Florida 7 3 3 7 20
Miami 14 3 7 7 31

🔢 Miami projected stats

  • Passing leader: Carson Beck - 23/33, 288 yards, 2 TD, 1 INT
  • Rushing leader: Mark Fletcher Jr. - 17 rushes, 94 yards, 1 TD
  • Receiving leader: CJ Daniels - 6 receptions, 88 yards, 1 TD

🔢 Florida projected stats

  • Passing leader: DJ Lagway - 21/34, 238 yards, 1 TD, 1 INT
  • Rushing leader: Jadan Baugh - 16 rushes, 86 yards
  • Receiving leader: Vernell Brown III - 6 receptions, 76 yards, 1 TD

🆚 Florida vs. Miami preview

Miami’s profile through three weeks is clean: Carson Beck is operating at an elite efficiency clip and the run game has a reliable hammer in Mark Fletcher Jr. That balance, plus a front seven keyed by Rueben Bain Jr., has paired points per drive with field-position wins. At home, under the lights at Hard Rock, the Hurricanes project to sustain drives and finish more red-zone trips.

Florida needs a turnover-light night from DJ Lagway and steady production from Jadan Baugh to keep the game on script. The Gators have real perimeter juice with freshman Vernell Brown III, but recent offense-wide inconsistencies and a key defensive injury up front raise the degree of difficulty on the road. Our model leans Miami by two scores, with efficiency on early downs and pass protection separating the Hurricanes late.


🏈 Illinois vs. Indiana prediction

College Football AI Predictions Week 4: ATS Picks & Score Projections for Saturday
Pictured: Illinois Fighting Illini quarterback Luke Altmyer (9) celebrates with teammates against the Western Michigan Broncos. Photo by Ron Johnson / Imagn Images.

🚨 Illinois vs. Indiana projected score

Team 1Q 2Q 3Q 4Q Final
Illinois 7 10 7 3 27
Indiana 3 7 7 6 23

🔢 Illinois projected stats

  • Passing leader: Luke Altmyer - 21/33, 268 yards, 2 TD
  • Rushing leader: Aidan Laughery - 15 rushes, 78 yards
  • Receiving leader: Malik Elzy - 5 receptions, 92 yards, 1 TD

🔢 Indiana projected stats

  • Passing leader: Fernando Mendoza - 22/35, 254 yards, 2 TD, 1 INT
  • Rushing leader: Kaelon Black - 16 rushes, 84 yards
  • Receiving leader: Elijah Sarratt - 8 receptions, 101 yards, 1 TD

🆚 Illinois vs. Indiana preview

Illinois arrives with a veteran quarterback playing clean, efficient football; Luke Altmyer has been sharp to start 2025, and the Illini’s receiver depth (Malik Elzy, Hank Beatty, Justin Bowick) gives them reliable answers on passing downs. That, plus a physical front and an edge presence in Gabe Jacas, positions Illinois to win enough early downs and keep the game in Altmyer’s hands.

Indiana’s identity under Curt Cignetti still leans on the ground, and even with RB Lee Beebe Jr. out for the season, the tandem of Kaelon Black and Roman Hemby can churn out steady gains while Fernando Mendoza distributes to Elijah Sarratt and Omar Cooper Jr. The margin comes down to protection and finishing drives; our model gives a slight edge to Illinois’ passing efficiency and red-zone execution in a one-score road win.

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