Early Boise State vs. South Florida Prediction, Odds & Picks: Week 1

Last Updated: August 26, 2025 8:19 AM EDT • 4 minute read X Social Google News Link

The early Boise State vs. South Florida odds highlight the latest betting lines and my picks for Thursday's clash as Week 1 of the college football season gets underway with AP top 25 action.
As part of the College Football Week 1 predictions, I use my early Boise State vs. South Florida prediction & picks to look at key betting numbers ahead of the action from Raymond James Stadium in Tampa, Fla., at 5:30 p.m. ET (ESPN).
No. 25 Boise State can be found as short as a 5.5-point betting favorite on the road, with the total dipping as low as O/U 62.5 points.
Best Boise State vs. South Florida early prediction: Week 1 💰
🔎 College football picks made Monday; odds subject to change. Our NEW college football player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!
Prediction: Boise State -6 ⭐⭐⭐⭐
Best odds: -110 via BetMGM | Implied probability: 52.38%
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Ashton Jeanty and his 2,600-plus rushing yards are gone from last year’s Broncos team, and I won’t begin to pretend he is easily replaceable. But there is still plenty of talent left on the roster, and my Boise State vs. South Florida early predictions give a confident four-star lean to the Broncos at anything less than a touchdown.
Boise State brings back 67% of its production (13th-highest among FBS teams) from last year and is the only Mountain West team that returns players with more than 200 combined starts.
Quarterback Maddux Madsen is back, and an offensive line that suffered numerous injuries but still paved the way for a phenomenal season from Jeanty is healthy to start the season.
The Broncos should exploit a Bulls defense projected to finish outside the top 100 in Defensive SP+, while South Florida’s offense should struggle early after losing last season's top three running backs and two wide receivers.
Boise State vs. South Florida early odds 📈
See the college football odds from our best college football betting sites.
Boise State vs. South Florida opening odds
- Moneyline: Boise State -300 | South Florida +240
- Spread: Boise State -9.5 (110) | South Florida +9.5 (-110)
- Over/Under: Over 63.5 (-110) | Under 63.5 (-110)
Boise State vs. South Florida odds analysis
Boise State plummeted from a 9.5-point favorite down to -6, with only FanDuel a half-point higher at -6.5 (-110).
The Broncos are the only AP-ranked Group of Five team and are coming off a College Football Playoff appearance. And considering they are receiving 69% of point spread wagers, Broncos backers will want to jump on any +6s that remain before the line heads back to a touchdown or higher.
The total has been the much more stable number, with Caesars and bet365 coming down from 64 to align with all the other top sports betting sites at 63.5.
There is nearly dead-even two-way action on O/U wagers thus far, so this line shouldn't fluctuate much more before kickoff.
Don't miss our guide for how to bet on college football or this week's best sportsbook promos.

Boise State vs. South Florida injuries to watch 🚑
Boise State vs. South Florida betting insights 📊
Here are some betting insights from our college football odds on Tuesday morning
- The spread opened at Boise State -9.5 but as has been bet as low as -5.5 despite 69% of the wagers on the cover
- The moneyline has shifted, with the opening line of South Florida +240 still sitting as long as +200
- A small majority of the wagers have been on the Under (52%) with the opening line (63.5) moving as low as 62.5
How to watch Boise State vs. South Florida 📺
- When: Thursday, Aug. 28
- Kickoff: 5:30 p.m. ET
- Where: Raymond James Stadium (Tampa, Fla.)
- How to watch: ESPN
- Weather: 91 degrees, 39% chance of precipitation, wind 7 mph ENE
- Favorite: Boise State -6 (-110 via BetMGM)
Expert early Week 1 college football predictions, odds & picks 💡
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College football betting odds pages 📃
CFP National Championship Odds | Heisman Trophy odds | College Football Playoff Odds | College Football Playoff Bracket |
ACC Odds | Big Ten Odds | Big 12 Odds | SEC Odds |
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Mike Spector X social