College Football Predictions Week 1 2025: Best Bets & Odds for Top Games

Our college football predictions for Week 1 cover the loaded opening week of games, including the much anticipated Monday night finale between TCU and North Carolina.

While Arch Manning and Texas dominated the conversation coming into the week, before falling to the college football championship odds favorites, the story over the last few games is how Notre Dame's new QB will look and the debut of Bill Belichick in Chapel Hill.

Don't miss any of our college football picks through Monday's action.

🏈 College football predictions for Week 1

Here are all of our college football expert picks for tonight's matchup, the last of Week 1:

• TCU vs. North Carolina early odds
• TCU vs. North Carolina prediction
• TCU vs. North Carolina player props
• TCU vs. North Carolina parlay picks
• TCU vs. North Carolina touchdown scorer predictions

💰 College football odds & expert picks: Week 1

Here are the latest odds for every Week 1 game via the best college football betting sites, which update live in real time. 

📊 TCU vs. North Carolina odds

• Date: Monday, Sept. 1
• Kickoff: 8 p.m. ET
• Location: Kenan Stadium (Chapel Hill, N.C.)
• How to watch: ESPN
• Pick: TCU -3.5 (-110 via BetMGM)

🔮 TCU vs. North Carolina prediction: TCU -3.5

Here's an excerpt from our TCU vs. North Carolina prediction on why Mike Spector predicts TCU will win and cover the spread: 

"Only the second head coach to win a Super Bowl and then coach at the college level, nobody can doubt Belichick’s resume. But his influence on a roster that features 70 new players will take more time, which makes me wonder why the Horned Frogs are such a short betting favorite."

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🎯 College football Week 1 expert picks

• College football picks against the spread Week 1
• College football upset picks Week 1
• College football trends that matter Week 1
• College football moneyline parlay Week 1
• College football best bets Week 1
• College football player props Week 1
• College football anytime touchdown scorer predictions Week 1
• College football picks Week 1
• College football AI predictions for Week 1

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