Premier League Predictions, Odds for Matchday 1: Opening Weekend EPL Best Bets

Matchday 1 has arrived as we examine the best Premier League bets for opening weekend, offering predictions for Manchester City, Chelsea, and Liverpool.

Gary Pearson

Last Updated: August 14, 2025 9:16 AM EDT • 5 minute read

Premier League Predictions, Odds for Matchday 1: Liverpool, Man City, Chelsea Best Bets — Pictured: Mo Salah in action during the Community Shield as we offer our Premier League Predictions. Photo by Liam Asman via Imagn Images.

The only thing more exciting than opening weekend is knowing the world's top league will be on display until May, and we have a quartet of tantalizing picks in our Premier League predictions.

Liverpool are the Premier League odds favorites at our best soccer betting sites entering the 2025-26 season, with Manchester City and Chelsea receiving the third- and fourth-shortest odds.

While those three contenders headline our picks, we also offer a bonus bet featuring one of the relegation front-runners.

🏴󠁧󠁢󠁥󠁮󠁧󠁿 Premier League predictions & odds for Matchday 1

Here are my Premier League predictions for opening weekend. Odds are provided by our best sports betting apps.

Liverpool vs. Bournemouth: Liverpool win & Bournemouth not to score (+135 via BetMGM) ⭐⭐⭐⭐
Wolves vs. Man City: Manchester City win & Over 1.5 goals (-150 via BetMGM) ⭐⭐⭐
Chelsea vs. Crystal Palace: Chelsea win & Under 3.5 goals (+115 via DraftKings) ⭐⭐⭐⭐
Leeds vs. Everton: Under 2.5 goals (-132 via FanDuel) ⭐⭐⭐⭐

💰 Liverpool win & Bournemouth not to score ⭐⭐⭐⭐

Best odds: +135 via BetMGM ($10 returns $13.50 profit)
Implied win probability: 42.55%

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The reigning champions conceded 16 goals in 19 matches at Anfield last season, showcasing their defensive dominance throughout the campaign. It was the joint-best defensive record in the top flight, tied with Nottingham Forest and their Matchday 1 opponent, Bournemouth.

The Reds have kept three straight clean sheets against the Cherries, outscoring them 9-0. Their last head-to-head at Anfield resulted in a 3-0 Liverpool victory.

I expect that trend to continue in the opener, with Liverpool kicking off the defense of their championship with another clean-sheet triumph. BetMGM offers the best price of our top sports betting apps, with DraftKings closest at +125.

📊 Liverpool vs. Bournemouth live odds

💰 Man City win & Over 1.5 goals ⭐⭐⭐

Best odds: -150 via BetMGM ($10 returns $6.67 profit)
Implied win probability: 60%

Despite their comparative offensive struggles on enemy ground last season, the Cityzens scored the second-most goals overall (72). Meanwhile, Wolves conceded 32 at home, the seventh-most.

Wolves defender Yerson Mosquera is set to return after missing last season with a horrific ACL and MCL rupture. While Wolves will be delighted by his return, he'll require some time to get up to the lightning-quick pace of the Premier League.

Facing Man City on his return will be about as forgiving as running full tilt into a brick wall.

Wolves have historically been woeful in August, with a solitary victory since returning to the Premier League seven years ago. That rotten run should continue against a highly motivated City side. It's a three-star play solely due to the short odds and decreased potential return.

📊 Wolves vs. Man City live odds

💰 Chelsea win & Under 3.5 goals ⭐⭐⭐⭐

Best odds: +115 via DraftKings ($10 returns $11.50 profit)
Implied win probability: 46.51%

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Seven of the previous eight meetings between these London rivals ended with three goals or fewer, with both of last season's head-to-head tilts ending deadlocked at one.

With the joint-sixth-best defensive record on the road, allowing 25 goals, Crystal Palace were as stingy in hostile environments as a family of five saving for a down payment on a house.

The Blues, meanwhile, will be excited about their fresh slate, especially after winning the Club World Cup. Chelsea splashed out in the transfer market, which is about as surprising as a horse eating hay.

The club spent over $320 million on eight players, including the formidable $82-million man, Joao Pedro.

While it will take some time for Enzo Maresca to source the starting 11 that offers the best cohesion and chemistry, the Blues should have enough to take all three points.

📊 Chelsea vs. Crystal Palace live odds

💰 Leeds vs. Everton: Under 2.5 goals ⭐⭐⭐⭐

Best odds: -132 via FanDuel ($10 returns $11.50 profit)
Implied win probability: 56.90%

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The first bit of business for Leeds United upon their return to the Premier League is to source some defensive stability. In 2022-23, their previous season in the top flight, Leeds shipped 78 goals, the most of any team.

They allowed 30 in 46 matches last season, the second-fewest in the Championship, en route to guaranteed promotion.

I imagine Daniel Farke will do everything in his power to remain tight at the back. They play their first match at Elland Road, a notoriously hostile environment for opposing teams, which Everton will be acutely aware of.

The visiting Toffees struggled to muster offense again last season, scoring the fewest goals (42) of any team that remained in the top flight. I don't see that changing on opening day against an adrenaline-fueled and organized Leeds United.

FanDuel offers the edge here, providing -132 odds. Caesars (-135) is closest, while DraftKings (140) and BetMGM (-145) offer the least value.

📊 Leeds vs. Everton live odds

💡 Premier League expert picks

Premier League odds & predictions
Premier League predictions for Matchday 1
Liverpool vs. Bournemouth prediction
Wolves vs. Man City prediction
Chelsea vs. Crystal Palace prediction
Man United vs. Arsenal prediction
Leeds United vs. Everton prediction

Soccer betting odds pages

World Cup Odds	EPL Title Odds
Women's World Cup Odds	UEFA Champions League Odds

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Each betting site featured on SBR has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.

Written by:
Gary Pearson

Gary Pearson has written professionally since 2010, focusing on sports betting since 2014. Before entering the sports betting space, he contributed to the Canadian Press, FanSided, the Hockey Writers, the Calgary Herald, and other publications. His work has also been featured in Sports Illustrated and Bleacher Report. Gary, who consumes sports like a blue whale devours plankton, has a penchant for writing predictions and analyses across several sports, including hockey, soccer, football, tennis, and more. He bets regularly, preferring single-game picks, props, and live betting. While there isn't a sport he has yet to dabble in, Gary prefers betting on soccer, hockey, and football. He studied at various post-secondary institutions, including the University of Calgary, SAIT Polytechnic, and Griffith University, located in Brisbane, Australia. Gary has a marketing degree and completed his bachelor's degree in journalism at Griffith University. He feels strongly that life experience is as essential as post-secondary education, helping formulate more accurate predictions and analyses. Gary believes that competing at a high level of amateur sports during his formative years helped him better understand an athlete's psyche and the nuances and complexities of a team's dynamic, both on and off the playing surface. He feels that knowledge is immeasurably important when offering his analytical expertise. He has lived on five continents and currently resides in Canada.