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Champions League Odds & Best Bets This Week for the Round of 16 Second Leg

Anthony Wootton

Last Updated: March 8, 2023 8:09 AM EST • 2 min 38 sec read.

Kylian Mbappe and Lionel Messi of PSG are back in action in our Champions League Best Bets.
Paris Saint-Germain's Argentine forward Lionel Messi (R) celebrates with Paris Saint-Germain's French forward Kylian Mbappe (L) after scoring a goal during the French L1 football match between Paris Saint-Germain (PSG) and FC Nantes on March 4.

Tuesday's Champions League action saw Benfica dispatch Brugge 5-1 and Chelsea top Dortmund by a 2-0 count. Read on for our Champions League best bets for Wednesday's Round of 16 play based on the best Champions League odds.

Champions League fans will want to get their Bayern vs. PSG picks in before their 3 p.m. ET match on Wednesday. Tottenham and AC Milan will meet at the same time as this week's Champions League Round of 16 second-leg action concludes.

Eight more teams will play next Tuesday and Wednesday to decide the quarterfinal matchups.

Here are our best Champions League bets from the Round of 16's second leg (odds via Caesars Sportsbook, DraftKings Sportsbook, and FanDuel Sportsbook; pick confidence based on a 1-to-5-star scale).

Check out our soccer picks.

Champions League schedule and odds this week

(odds via DraftKings as of March 8 at 8:08 a.m. ET)

  • Bayern Munich (-135) vs. PSG (+315)
  • Tottenham (-115) vs. Milan (+340)

Champions League best bets

  • Moneyline: PSG (+290 via Caesars) vs. Bayern Munich ⭐⭐⭐
  • Prop: Tottenham to advance vs. Milan (+140 via Caesars) ⭐⭐⭐

Check out our best Champions League odds.

Top Champions League picks

Moneyline: PSG (+290) vs. Bayern Munich (+290 via Caesars) ⭐⭐⭐

There’s no Neymar for Paris Saint-Germain, but the French champions are unbeaten when Lionel Messi and Kylian Mbappe have partnered each other without him in the side. Mbappe broke the all-time scoring record for PSG at the weekend, and when he was asked about his future he said, “winning the Champions League.” Only Liverpool’s Mohamed Salah (8) has scored more goals than Mbappe (7) in this season’s competition. Messi leads the tournament for the most assists (4). 

Bayern Munich have won 15 of their last 17 home games in the Champions League, although their only defeat during that span was to PSG. Messi is one goal away from joining Cristiano Ronaldo as the only players to score 50 goals in the knockout stages of the competition. The European crown is what PSG crave more than any title. They’ve got the players to turn this tie around. 

The +290 odds from Caesars are the best among our top five books for this play. BetMGM and PointsBet price PSG as low as +260, while the next highest odds are +270 via FanDuel. I like this play because of how much this tournament means to the French club. Messi’s had a phenomenal season so far and a Champions League crown will be the cherry on the top.

Prop: Tottenham to advance vs. Milan (+140 via Caesars) ⭐⭐⭐

Milan head to London with a 1-0 advantage. However, these two sides are having similar seasons in their respective domestic leagues. Both have won 14 games, both currently occupy fourth place and both have lost their most-recent match. 

Spurs have progressed from two of their last three European ties after losing the first leg. Milan have only ever won one of their 21 away games against English sides in all European competitions. Tottenham’s Italian head coach, Antonio Conte, returns to the dugout after recovering from gallbladder surgery. Conte is a fierce winner, who coached Milan’s arch rivals Inter to the Italian championship in 2021. Conte has won five of his last six home games against AC Milan in all competitions. 

Whichever way they get through, home advantage will be a key factor in this tie for Spurs. We just need them to advance to win this play. Tottenham has the superior squad, which should see them progress. 

FanDuel’s odds for this play is +122, with DraftKings at +135. Caesars is offering the best price at +140.  

Champions League best bets made 3/5/2023 at 2:30 p.m. ET.

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Written By:
Anthony Wootton
Anthony is an accredited NFL journalist and has been reporting on the league for over a decade, covering the London games for the BBC and other broadcast outlets. He's presented a North American sports show for national radio across the UK, which is now the TransAtlantic Sports Show podcast. Anthony has also produced and presented radio documentaries on football for global audiences. He has years of betting experience, writing NFL tips for some of the industry's biggest sportsbooks. He's a producer of sports content, including Premier League, LaLiga, Bundesliga, Champions League, and international soccer. He's a keen follower of sport, and a long-time sufferer of English Championship team, Blackburn Rovers. He's a keen runner and completed a challenge of running every day in 2021, which included a minimum distance of 5km in the rules.