NFL Odds for Week 6: Betting Lines, Spreads & Totals for Every Game
📊 NFL odds Week 6, 2025
The NFL odds for Week 6 are via bet365.
| Game | Spread | Moneyline | Over/Under |
|---|---|---|---|
| Eagles vs. Giants (TNF) | Giants +7.5 | Eagles -390 / Giants +310 | 41.5 (-110/-110) |
| Broncos vs. Jets (London) | Jets +7 | Broncos -380 / Jets +300 | 43.5 (-110/-110) |
| Cardinals vs. Colts | Colts -6.5 | Cardinals +240 / Colts -300 | 47.5 (-110/-110) |
| Browns vs. Steelers | Steelers -5 | Browns +200 / Steelers -245 | 38 (-110/-110) |
| Cowboys vs. Panthers | Panthers +3.5 | Cowboys -190 / Panthers +160 | 49.5 (-110/-110) |
| Chargers vs. Dolphins | Dolphins +4 | Chargers -220 / Dolphins +180 | 43.5 (-110/-110) |
| Rams vs. Ravens | Ravens +7.5 | Rams -400 / Ravens +320 | 45 (-110/-110) |
| Patriots vs. Saints | Saints +3.5 | Patriots -205 / Saints +170 | 46 (-110/-110) |
| Seahawks vs. Jaguars | Jaguars -1 | Seahawks -105 / Jaguars -115 | 46.5 (-110/-100) |
| Titans vs. Raiders | Raiders -4.5 | Titans +200 / Raiders -245 | 41.5 (-110/-110) |
| Bengals vs. Packers | Packers -14.5 | Bengals +700 / Packers -1100 | 44 (-110/-110) |
| 49ers vs. Buccaneers | Buccaneers -3 | 49ers +135 / Buccaneers -160 | 47.5 (-110/-110) |
| Lions vs. Chiefs (SNF) | Chiefs -1.5 | Lions +100 / Chiefs -120 | 50.5 (-110/-110) |
| Bills vs. Falcons (MNF) | Falcons +3.5 | Bills -205 / Falcons +170 | 48.5 (-110/-110) |
| Bears vs. Commanders (MNF) | Commanders -4.5 | Bears +185 / Commanders -225 | 50 (-110/-110) |
Our NFL picks are loaded up for another week, and we have 15 games to choose from with only the Minnesota Vikings and Houston Texans on a bye.
- The Thursday Night Football odds highlight an NFC East rivalry, with the Eagles a 7.5-point road betting favorite over the Giants; kickoff is at 8:15 p.m. ET (Prime Video)
- The league stays in England on Sunday with the Broncos a 7-point betting favorite over the Jets at Tottenham Hotspur Stadium in London (9:30 a.m. ET, NFL Network)
- The Lions and Chiefs clash to wrap up Sunday's action, with the Sunday Night Football odds showing the Chiefs as the 1.5-point betting favorite (8:20 p.m. ET, NBC)
- The Monday Night Football odds again treat us to a doubleheader:
- The Bills are a 3.5-point road betting favorite against the Falcons in Atlanta (7:15 p.m. ET, ESPN)
- The Commanders are a 4.5-point betting favorite as they host the Bears (8:15 p.m. ET, ABC)
- The week's biggest spread as of Monday morning: Packers -14.5 vs. Bengals
- The week's biggest total as of Monday morning: 50.5 points for Lions vs. Chiefs
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📈 Week 6 biggest line movement
↕️ The biggest changes to the Week 6 lines
- The Colts' strong performance (40-6 win vs. Raiders) boosted them from -3.5 to -6.5, while the Cardinals floundered in a 22-21 loss to the previously winless Titans
- An abysmal showing from the Ravens (44-10 loss to Texans) moved them from a 5.5 to 7.5-point underdog against the Rams
- The Bucs picked up a road win as an underdog (38-35 vs. Seahawks) and jumped from -1.5 to -3 against the visiting 49ers
- The Bills tightened from from -5.5 to -3.5 against the Falcons following Buffalo's first loss of the season (23-20 vs. Patriots)
- The Bills vs. Falcons also saw their total fall from 50.5 to 48.5 as Buffalo's offense looked pedestrian for a second consecutive week
🚑️ Key injuries suffered in Week 5
- Cardinals QB Kyler Murray suffered a foot injury, and his status for Week 6 remains up in the air
- Colts K Spencer Shrader has been diagnosed with a torn ACL and MCL and is sidelined for the season
- Chiefs WR Xavier Worthy left briefly with an ankle injury but was able to return to finish MNF
- Chargers RB Omarion Hampton will be placed on injured reserve with an ankle injury
🏈 Eagles vs. Giants odds: Thursday Night Football
- Kickoff: 8:15 p.m. ET from MetLife Stadium (East Rutherford, N.J.)
- How to watch: Prime Video
- Eagles vs. Giants early prediction
🏈 Broncos vs. Jets odds: NFL London Game
- Kickoff: 9:30 a.m. ET from Tottenham Hotspur Stadium (London)
- How to watch: NFL Network
- Broncos vs. Jets early prediction
🏈 Lions vs. Chiefs odds: Sunday Night Football
- Kickoff: 8:20 p.m. ET from GEHA Field at Arrowhead Stadium (Kansas City, Mo.)
- How to watch: NBC
- Lions vs. Chiefs early prediction
🏈 Bills vs. Falcons odds: Monday Night Football
- Kickoff: 7:15 p.m. ET from Mercedes-Benz Stadium (Atlanta)
- How to watch: ESPN
- Bills vs. Falcons early prediction
🏈 Bears vs. Commanders odds: Monday Night Football
- Kickoff: 8:15 p.m. ET from Northwest Stadium (Landover, Md.)
- How to watch: ABC
- Bears vs. Commanders early prediction
🔢 NFL Week 6 odds and lines
There's an advantage to betting early NFL odds when attempting to beat the closing line. The closer you wait until kickoff to make your NFL picks, the harder it becomes to identify edges and secure the best price on most sides or totals.
❓NFL odds FAQs
Who's playing on prime time in Week 6?
The Eagles visit the Giants on Thursday Night Football, while the Chiefs host the Lions on Sunday Night Football. Sunday action opens with an International Series game as the Broncos and Jets clash in London, and the week closes with a Monday Night Football doubleheader: Bills at Falcons, Bears at Commanders.
How do NFL spread odds work?
When betting on the NFL, the favorite needs to win by a certain number of points to cover the "point spread" - also known as the betting line. Conversely, the underdog needs to lose by fewer than the points displayed in the spread or win outright to cash. For example, a 3-point favorite would need to win by more than a field goal to reward bettors.
How do NFL moneyline odds work?
When betting on the NFL, the underdog will have the "longer" odds and is typically priced at "plus-money" odds that indicate the profit on a $100 bet. For example, a team with +150 odds would turn a $100 bet into a $150 profit - or a $10 bet into a $15 profit - according to our odds converter.
Where can I find the NFL betting odds?
Shop around our best NFL betting sites to find the best odds for your college football picks. Our best sports betting sites for all sports include BetMGM, bet365, Caesars, FanDuel, and DraftKings.
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