NFL Odds Week 6: Betting Lines, Spreads & Totals for Every Game

📊 NFL odds Week 6, 2025

The NFL odds for Week 6 are via bet365.

Our NFL picks are loaded up for another week, and we have 15 games to choose from with only the Minnesota Vikings and Houston Texans on a bye.

• The Thursday Night Football odds highlight an NFC East rivalry, Eagles a 5.5-point road betting favorite over the Giants; kickoff is at 8:15 p.m. ET (Prime Video)
• The league stays in England as Sunday opens with the Broncos a 6.5-point betting favorite over the Jets at Tottenham Hotspur Stadium in London (9:30 a.m. ET, NFL Network)
• The Lions and Chiefs clash to wrap up the day's action, with the Sunday Night Football odds showing the Chiefs as the 1.5-point betting favorite (8:20 p.m. ET, NBC)
• The Monday Night Football odds again treat us to a doubleheader:
• The Bills are a 5.5-point road betting favorite against the Falcons in Atlanta (7:15 p.m. ET, ESPN)
• The Commanders are a 5-point betting favorite as they host the Bears (8:15 p.m. ET, ABC)
• The weeks biggest opening spread: Packers -13.5 vs. Bengals
• The weeks biggest opening total: 50.5 points for both Monday Night Football games

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🏈 Eagles vs. Giants odds: Thursday Night Football

• Kickoff: 8:15 p.m. ET from MetLife Stadium (East Rutherford, N.J.)
• How to watch: Prime Video

🏈 Broncos vs. Jets odds: NFL London Game

• Kickoff: 9:30 a.m. ET from Tottenham Hotspur Stadium (London)
• How to watch: NFL Network

🏈 Lions vs. Chiefs odds: Sunday Night Football

• Kickoff: 8:20 p.m. ET from GEHA Field at Arrowhead Stadium (Kansas City, Mo.)
• How to watch: NBC

🏈 Bills vs. Falcons odds: Monday Night Football

• Kickoff: 7:15 p.m. ET from Mercedes-Benz Stadium (Atlanta)
• How to watch: ESPN

🏈 Bears vs. Commanders odds: Monday Night Football

• Kickoff: 8:15 p.m. ET from Northwest Stadium (Landover, Md.)
• How to watch: ABC

🔢 NFL Week 6 odds and lines

There's an advantage to betting early NFL odds when attempting to beat the closing line. The closer you wait until kickoff to make your NFL picks, the harder it becomes to identify edges and secure the best price on most sides or totals.

❓NFL odds FAQs

Who's playing on prime time in Week 6?

The Eagles visit the Giants on Thursday Night Football, while the Chiefs host the Lions on Sunday Night Football. Sunday action opens with an International Series game as the Broncos and Jets clash in London, and the week closes with a Monday Night Football doubleheader: Bills at Falcons, Bears at Commanders.

How do NFL spread odds work?

When betting on the NFL, the favorite needs to win by a certain number of points to cover the "point spread" - also known as the betting line. Conversely, the underdog needs to lose by fewer than the points displayed in the spread or win outright to cash. For example, a 3-point favorite would need to win by more than a field goal to reward bettors.

How do NFL moneyline odds work?

When betting on the NFL, the underdog will have the "longer" odds and is typically priced at "plus-money" odds that indicate the profit on a $100 bet. For example, a team with +150 odds would turn a $100 bet into a $150 profit - or a $10 bet into a $15 profit - according to our odds converter.

Where can I find the NFL betting odds?

Shop around our best NFL betting sites to find the best odds for your college football picks. Our best sports betting sites for all sports include BetMGM, bet365, Caesars, FanDuel, and DraftKings.