NFL Odds Week 5: Betting Lines, Spreads & Totals for Every Game
📊 NFL odds Week 5, 2025
The NFL odds for Week 5 are via bet365.
| Game | Spread | Moneyline | Over/Under |
|---|---|---|---|
| 49ers vs. Rams (TNF) | Rams -3 | 49ers +135 / Rams -160 | 47 (-110/-110) |
| Vikings vs. Browns (London) | Browns +4.5 | Vikings -225 / Browns +185 | 38.5 (-110/-110) |
| Cowboys vs. Jets | Jets +1.5 | Cowboys -125 / Jets +105 | 46.5 (-110/-110) |
| Broncos vs. Eagles | Eagles -5.5 | Broncos +190 / Eagles -230 | 43.5 (-110/-110) |
| Texans vs. Ravens | Ravens -9.5 | Texans +375 / Ravens -500 | 46 (-110/-110) |
| Raiders vs. Colts | Colts -6.5 | Raiders +220 / Colts -270 | 48.5 (-110/-110) |
| Dolphins vs. Panthers | Panthers -1.5 | Dolphins +100 / Panthers -120 | 46.5 (-110/-110) |
| Giants vs. Saints | Saints +1.5 | Giants -125 / Saints +105 | 43.5 (-110/-110) |
| Buccaneers vs. Seahawks | Seahawks -1.5 | Buccaneers +105 / Seahawks -125 | 44.5 (-110/-100) |
| Titans vs. Cardinals | Cardinals -8 | Titans +325 / Cardinals -425 | 42 (-110/-110) |
| Lions vs. Bengals | Lions -7.5 | Lions -370 / Bengals +290 | 49.5 (-110/-110) |
| Commanders vs. Chargers | Chargers -3 | Commanders +130 / Chargers -155 | 48.5 (-110/-110) |
| Patriots vs. Bills (SNF) | Bills -10 | Patriots +390 / Bills -525 | 48.5 (-110/-110) |
| Chiefs vs. Jaguars (MNF) | Jaguars +3.5 | Chiefs -185 / Jaguars +155 | 44.5 (-110/-110) |
Even with four teams on bye, our NFL picks are plenty loaded. Week 5 sees the Atlanta Falcons, Chicago Bears, Green Bay Packers, and Pittsburgh Steelers on the sideline.
- An NFC showdown features in the Thursday Night Football odds, with the Rams a 3-point home betting favorite over the 49ers; kickoff is at 8:15 p.m. ET (Prime Video)
- The league stays in Europe as Sunday opens with the Vikings a 4.5-point betting favorite over the Browns at Tottenham Hotspur Stadium in London (9:30 a.m. ET, NFL Network)
- The Sunday Night Football odds look like a blowout in the making as the Bills -10 over the Patriots is the only double-digit spread to open the week (8:20 p.m. ET, NBC)
- The Monday Night Football odds look like a tighter game than once imagined, with the Jaguars a 3.5-point underdog to the visiting Chiefs head of kickoff at 8:15 p.m. ET (ABC/ESPN)
Bet $5, Get $300 in Bonus Bets Win or Lose*
*Deposit required. Mobile app only. Bonus Bets wager excluded from returns. T&Cs, time limits and exclusions apply. Gambling problem? Call 1-800-GAMBLER. Referral Codes are used for marketing/tracking purposes only.
Each product featured on our website has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.
🏈 49ers vs. Rams odds: Thursday Night Football
- Kickoff: 8:15 p.m. ET from SoFi Stadium (Inglewood, Calif.)
- How to watch: Prime Video
🏈 Vikings vs. Browns odds: NFL London Game
- Kickoff: 9:30 a.m. ET from Tottenham Hotspur Stadium (London)
- How to watch: NFL Network
🏈 Patriots vs. Bills odds: Sunday Night Football
- Kickoff: 8:20 p.m. ET from Highmark Stadium (Orchard Park, N.Y.)
- How to watch: NBC
🏈 Chiefs vs. Jaguars odds: Monday Night Football
- Kickoff: 8:15 p.m. ET from EverBank Stadium (Jacksonville, Fla.)
- How to watch: ABC/ESPN
🔢 NFL Week 5 odds and lines
There's an advantage to betting early NFL odds when attempting to beat the closing line. The closer you wait until kickoff to make your NFL picks, the harder it becomes to identify edges and secure the best price on most sides or totals.
❓NFL odds FAQs
Who's playing on prime time in Week 5?
The 49ers visit the Rams on Thursday Night Football, while the Bills host the Patriots on Sunday Night Football. Sunday action opens with an International Series game as the Vikings and Browns clash in London, and the week closes with the Chiefs and Jaguars on Monday Night Football.
How do NFL spread odds work?
When betting on the NFL, the favorite needs to win by a certain number of points to cover the "point spread" - also known as the betting line. Conversely, the underdog needs to lose by fewer than the points displayed in the spread or win outright to cash. For example, a 3-point favorite would need to win by more than a field goal to reward bettors.
How do NFL moneyline odds work?
When betting on the NFL, the underdog will have the "longer" odds and is typically priced at "plus-money" odds that indicate the profit on a $100 bet. For example, a team with +150 odds would turn a $100 bet into a $150 profit - or a $10 bet into a $15 profit - according to our odds converter.
Where can I find the NFL betting odds?
Shop around our best NFL betting sites to find the best odds for your college football picks. Our best sports betting sites for all sports include BetMGM, bet365, Caesars, FanDuel, and DraftKings.
(21+. Gambling Problem? Call 1-800-GAMBLER)
* Bonuses not applicable in Ontario.
Not intended for use in MA.
Each betting site featured on SBR has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.
Related Articles
