NFL Odds Week 2: Lines, Spreads & Totals for Every Game
📊 NFL odds Week 2, 2025
The NFL odds for Week 2 are via bet365, as of Wednesday, Sept. 3
| Game | Spread | Moneyline | Over/Under |
|---|---|---|---|
| Commanders vs. Packers (TNF) | Packers -2.5 | Commanders +140 / Packers -165 | 48.5 (-110/-110) |
| Bills vs Jets | Jets +8.5 | Bills -400 / Jets +320 | 44.5 (-110/-110) |
| Bears vs. Lions | Lions -4.5 | Bears +205 / Lions -250 | 48.5 (-110/-110) |
| Browns vs. Ravens | Ravens -12.5 | Browns +500 / Ravens -700 | 44.5 (-110/-110) |
| Jaguars vs. Bengals | Bengals -5.5 | Jaguars +205 / Bengals -250 | 49.5 (-110/-110) |
| Rams vs. Titans | Titans +5.5 | Rams -245 / Titans +200 | 45.5 (-110/-110) |
| Patriots vs. Dolphins | Dolphins -2.5 | Patriots +125 / Dolphins -150 | 45.5 (-110/-110) |
| Giants vs. Cowboys | Cowboys -3 | Giants +135 / Cowboys -160 | 44.5 (-110/-110) |
| Seahawks vs. Steelers | Steelers -2.5 | Seahawks +120 / Steelers -140 | 41.5 (-110/-100) |
| 49ers vs. Saints | Saints +7 | 49ers -330 / Saints +265 | 44.5 (-110/-110) |
| Panthers vs. Cardinals | Cardinals -4.5 | Panthers +185 / Cardinals -225 | 46.5 (-110/-110) |
| Broncos vs. Colts | Colts +3.5 | Broncos -185 / Colts +155 | 44.5 (-110/-110) |
| Eagles vs. Chiefs | Chiefs -1.5 | Eagles +105 / Chiefs -125 | 45.5 (-110/-110) |
| Falcons vs. Vikings (SNF) | Vikings -4.5 | Falcons +185 / Vikings -225 | 45.5 (-110/-110) |
| Buccaneers vs. Texans (MNF) | Texans -1.5 | Buccaneers +110 / Texans -130 | 46.5 (-110/-110) |
| Chargers vs. Raiders (MNF) | Raiders +3 | Chargers -160 / Raiders +135 | 44.5 (-110/-110) |
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Our NFL picks have long ago piled up for the first week of the season, and now is the time to get out Week 2 NFL odds.
For the first time during the NFL season, we're treated to a Monday Night Football doubleheader.
- The first official Thursday Night Football odds feature the Packers (-2.5) hosting the Commanders at 8:15 p.m. ET (Prime Video)
- The Ravens (-12.5), led by NFL MVP odds contender Lamar Jackson, are the first double-digit favorites of the season as they host the Browns on Sunday (1 p.m. ET, CBS)
- The Sunday Night Football odds have the Vikings (-4.5) hosting the Falcons in a clash between two of the league's more intriguing young signal-callers
- The Monday Night Football odds give us a doubleheader
- Houston is a 1.5-point betting favorite against visiting Tampa Bay in the early game at 7 p.m. ET (ABC/ESPN)
- An AFC West rivalry meeting between the Chargers (-3) and Raiders serves as the nightcap (10 p.m. ET, ESPN)
🏈 Commanders vs. Packers odds: Thursday Night Football
- Kickoff: 8:15 p.m. ET from Lambeau Field (Green Bay, Wisc.)
- How to watch: Prime Video
🏈 Falcons vs. Vikings: Sunday Night Football
- Kickoff: 8:20 p.m. ET from U.S. Bank Stadium (Minneapolis)
- How to watch: NBC
🏈 Buccaneers vs. Texans odds: Monday Night Football
- Kickoff: 7 p.m. ET from NRG Stadium (Houston)
- How to watch: ABC/ESPN
🏈 Chargers vs. Raiders odds: Monday Night Football
- Kickoff: 10 p.m. ET from Allegiant Stadium (Las Vegas)
- How to watch: ESPN
🔢 NFL Week 2 odds and lines
There's an advantage to betting early NFL odds when attempting to beat the closing line. The closer you wait until kickoff to make your NFL picks, the harder it becomes to identify edges and secure the best price on most sides or totals.
❓NFL odds FAQs
How do NFL spread odds work?
When betting on the NFL, the favorite needs to win by a certain number of points to cover the "point spread" - also known as the betting line. Conversely, the underdog needs to lose by fewer than the points displayed in the spread or win outright to cash. For example, a 3-point favorite would need to win by more than a field goal to reward bettors.
How do NFL moneyline odds work?
When betting on the NFL, the underdog will have the "longer" odds and is typically priced at "plus-money" odds that indicate the profit on a $100 bet. For example, a team with +150 odds would turn a $100 bet into a $150 profit - or a $10 bet into a $15 profit - according to our odds converter.
Where can I find the NFL betting odds?
Shop around our best NFL betting sites to find the best odds for your college football picks. Our best sports betting sites for all sports include BetMGM, bet365, Caesars, FanDuel, and DraftKings.
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