NFL Odds Week 15: Betting Lines, Spreads & Totals for Every Game

We look at the NFL odds and Week 15 lines & spreads, focusing on the biggest line movements and impact injuries moving the betting lines.
The Tampa Bay Buccaneers mascot as we look at the Week 15 NFL odds
Pictured: The Tampa Bay Buccaneers mascot as we look at the Week 15 NFL odds. Photo by Nathan Ray Seebeck-Imagn Images
Enjoying SBR content? Add us as a preferred source on your Google account Add as a preferred source on Google

NFL odds Week 15, 2025

The NFL odds for Week 15 are via bet365.

Game Spread  Moneyline Over/Under
Falcons vs. Buccaneers (TNF) Buccaneers -5.5 ATL +195 / TB -240 44.5
Cardinals vs. Texans Texans -7 ARI +260 / HOU -320 42.5
Ravens vs. Bengals Bengals +3 BAL -155 / CIN +130 51.5
Bills vs. Patriots Patriots -1 BUF -110 / NE -110 47.5
Browns vs. Bears Bears -7 CLE +300 / CHI -380 39.5
Chargers vs. Chiefs Chiefs -4.5 LAC +170 / KC -205 43.5
Raiders vs. Eagles Eagles -12.5 LV +650 / PHI -1000 39.5
Jets vs. Jaguars Jaguars -9.5 NYJ +375 / JAX -500 43
Commanders vs. Giants Giants +1.5 WSH -130 / NYG +110 47.5
Panthers vs. Saints Saints +2.5 CAR -150 / NO +125 39.5
Lions vs. Rams Rams -4.5 DET +175 / LAR -210 51
Packers vs. Broncos Broncos +1.5 GB -125 / DEN +105 42
Colts vs. Seahawks Seahawks -3.5 IND +155 / SEA -185 46.5
Titans vs. 49ers 49ers -12.5 TEN +650 / SF -1000 42.5
Vikings vs. Cowboys (SNF) Cowboys -7.5 MIN +325 / DAL -425 47
Dolphins vs. Steelers (MNF) Steelers -3 MIA +140 / PIT -165 41.5

Our NFL picks will be locked and loaded for Week 15 as we head into the final weeks of the season with bye weeks all wrapped up.

  • The Thursday Night Football odds have the Buccaneers a 5.5-point home betting favorite against the Falcons in an NFC South clash at Raymond James Stadium (8:15 p.m. ET, Prime Video)
  • Sunday's action wraps with the Cowboys a 7.5-point home betting favorite over the Vikings per the Sunday Night Football odds, with kickoff from AT&T Stadium at 8:20 p.m. ET (NBC)
  • The Monday Night Football odds have the Steelers as a 3-point betting favorite against the Dolphins at Acrisure Stadium (8:15 p.m. ET, ESPN)

Falcons vs. Buccaneers odds: Thursday Night Football

  • Kickoff: 8:15 p.m. ET from Raymond James Stadium (Tampa, Fla.)
  • How to watch: Prime Video

Vikings vs. Cowboys odds: Sunday Night Football

  • Kickoff: 8:20 p.m. ET from AT&T Stadium (Arlington, Texas)
  • How to watch: NBC

Dolphins vs. Steelers odds: Monday Night Football

  • Kickoff: 8:15 p.m. ET from Acrisure Stadium (Pittsburgh)
  • How to watch: ESPN

NFL Week 15 odds and lines

There's an advantage to betting early NFL odds when attempting to beat the closing line. The closer you wait until kickoff to make your picks, the harder it becomes to identify edges and secure the best price on most sides or totals.

Who's playing on prime time in Week 15?

Week 15 opens with the Falcons and Buccaneers on Thursday Night Football. The Cowboys host the Vikings on Sunday Night Football, while the Dolphins visit the Steelers to finish the week on Monday Night Football.


📃 Affiliate disclosure

Sportsbook Review may receive a commission if you sign up through our links. Not intended for use in MA. Bonuses not applicable in Ontario. 21+ only. (Gambling problem? Call 1-800-GAMBLER)