NFL Betting Odds: Week 15 Lines, Spreads & Totals for TNF and Every Game
We look at the NFL odds and Week 15 lines & spreads, focusing on the biggest line movements and impact injuries moving the betting lines.
NFL odds Week 15, 2025
The NFL odds for Week 15 are via bet365.
| Game | Spread | Moneyline | Over/Under |
|---|---|---|---|
| Falcons vs. Buccaneers (TNF) | Buccaneers -4.5 | ATL +200 / TB -245 | 44.5 |
| Cardinals vs. Texans | Texans -9.5 | ARI +390 / HOU -525 | 42.5 |
| Ravens vs. Bengals | Bengals +2.5 | BAL -140 / CIN +120 | 51.5 |
| Bills vs. Patriots | Patriots +1 | BUF -115 / NE -105 | 49.5 |
| Browns vs. Bears | Bears -7.5 | CLE +300 / CHI -380 | 39 |
| Chargers vs. Chiefs | Chiefs -5.5 | LAC +220 / KC -270 | 41.5 |
| Raiders vs. Eagles | Eagles -11.5 | LV +525 / PHI -750 | 38 |
| Jets vs. Jaguars | Jaguars -13 | NYJ +600 / JAX -900 | 41.5 |
| Commanders vs. Giants | Giants -2.5 | WSH +120 / NYG -140 | 47 |
| Panthers vs. Saints | Saints +2.5 | CAR -155 / NO +130 | 40.5 |
| Lions vs. Rams | Rams -6 | DET +220 / LAR -270 | 55 |
| Packers vs. Broncos | Broncos +2 | GB -130 / DEN +110 | 42.5 |
| Colts vs. Seahawks | Seahawks -14 | IND +600 / SEA -800 | 42.5 |
| Titans vs. 49ers | 49ers -12.5 | TEN +575 / SF -850 | 44.5 |
| Vikings vs. Cowboys (SNF) | Cowboys -5.5 | MIN +220 / DAL -270 | 47.5 |
| Dolphins vs. Steelers (MNF) | Steelers -3.5 | MIA +155 / PIT -185 | 41.5 |
Our NFL picks will be locked and loaded for Week 15 as we head into the final weeks of the season with bye weeks all wrapped up.
- The Thursday Night Football odds have the Buccaneers a 4.5-point home betting favorite against the Falcons in an NFC South clash at Raymond James Stadium (8:15 p.m. ET, Prime Video)
- Sunday's action wraps with the Cowboys a 5.5-point home betting favorite over the Vikings per the Sunday Night Football odds, with kickoff from AT&T Stadium at 8:20 p.m. ET (NBC)
- The Monday Night Football odds have the Steelers as a 3.5-point betting favorite against the Dolphins at Acrisure Stadium (8:15 p.m. ET, ESPN)
↕️ Week 15 biggest line movement
- The Texans jumped from -7 to -9.5 against the Cardinals after shutting down the Chiefs (20-10) last week
- The Patriots have slipped from a 1-point favorite to a 1-point underdog against the visiting Bills; the total has grown from 47.5 to 49.5
- The Jags have gone from -9.5 to -13 against the Jets with New York's starting QB yet to be announced
- The Giants have moved from a 1.5-point underdog to a 2.5-point favorite following the Commanders being shut out 31-0 by the Vikings
- The Seahawks moved from -3.5 to -14 following the season-ending injury to Colts starting QB Daniel Jones; the total plummeted from 46.5 to 42.5
- The Lions-Rams total has grown from 51 to 55 following both Detroit and Los Angeles posting 40-burgers last week
Falcons vs. Buccaneers odds: Thursday Night Football
- Kickoff: 8:15 p.m. ET from Raymond James Stadium (Tampa, Fla.)
- How to watch: Prime Video
- Falcons vs. Buccaneers prediction
- Falcons vs. Buccaneers player props
Bills vs. Patriots odds: Game of the Week
- Kickoff: 1 p.m. ET from Gillette Stadium (Foxborough, Mass.)
- How to watch: CBS
- Early Bills vs. Patriots prediction
Vikings vs. Cowboys odds: Sunday Night Football
- Kickoff: 8:20 p.m. ET from AT&T Stadium (Arlington, Texas)
- How to watch: NBC
- Early Vikings vs. Cowboys prediction
Dolphins vs. Steelers odds: Monday Night Football
- Kickoff: 8:15 p.m. ET from Acrisure Stadium (Pittsburgh)
- How to watch: ESPN
- Early Dolphins vs. Steelers prediction
NFL Week 15 odds and lines
There's an advantage to betting early NFL odds when attempting to beat the closing line. The closer you wait until kickoff to make your picks, the harder it becomes to identify edges and secure the best price on most sides or totals.
Who's playing on prime time in Week 15?
Week 15 opens with the Falcons and Buccaneers on Thursday Night Football. The Cowboys host the Vikings on Sunday Night Football, while the Dolphins visit the Steelers to finish the week on Monday Night Football.
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