NFL Odds Week 12: Lines, Spreads & Totals for Every Game
📊 NFL odds Week 12, 2025
The NFL odds for Week 12 are via bet365.
| Game | Spread | Moneyline | Over/Under |
|---|---|---|---|
| Bills vs. Texans (TNF) | Texans +2.5 | BUF -135 / HOU +115 | 44 |
| Colts vs. Chiefs | Chiefs -4.5 | IND +180 / KC -220 | 50.5 |
| Vikings vs. Packers | Packers -6.5 | MIN +225 / GB -275 | 43.5 |
| Patriots vs. Bengals | Bengals +5.5 | NE -240 / CIN +195 | 51 |
| Giants vs. Lions | Lions -11.5 | NYG +450 / DET -600 | 49.5 |
| Jets vs. Ravens | Ravens -14.5 | NYJ +600 / BAL -900 | 44.5 |
| Steelers vs. Bears | Bears -1.5 | PIT +105 / CHI -125 | 46.5 |
| Seahawks vs. Titans | Titans +12.5 | SEA -700 / TEN +500 | 43.5 |
| Browns vs. Raiders | Raiders -2 | CLE +105 / LV -125 | 37.5 |
| Jaguars vs. Cardinals | Cardinals -1 | JAX +100 / ARI -120 | 45.5 |
| Falcons vs. Saints | Saints +3.5 | ATL -170 / NO +145 | 41.5 |
| Eagles vs. Cowboys | Cowboys +3.5 | PHI -205 / DAL +170 | 50.5 |
| Buccaneers vs. Rams (SNF) | Rams -6 | TB +220 / LA -270 | 49.5 |
| Panthers vs. 49ers (MNF) | 49ers -6.5 | CAR +240 / SF -300 | 45.5 |
Our NFL picks will be locked and loaded for Week 12, with the Denver Broncos, Miami Dolphins, Los Angeles Chargers, and Washington Commanders.
- The Thursday Night Football odds have the Bills as a 2.5-point road favorite against the Texans in Houston (8:15 p.m. ET, Prime Video)
- Sunday's action wraps with a high-level NFC clash as Rams are spotting the Bucs 6 points per the Sunday Night Football odds (8:20 p.m. ET, NBC)
- One game in the Monday Night Football odds as the week wraps up, with the 49ers a 6.5-point home betting favorite against the visiting Panthers (8:15 p.m. ET, ESPN)
🏈 Bills vs. Texans odds: Thursday Night Football
- Kickoff: 8:15 p.m. ET from NRG Stadium (Houston)
- How to watch: Prime Video
🏈 Buccaneers vs. Rams odds: Sunday Night Football
- Kickoff: 8:20 p.m. ET from SoFi Stadium (Inglewood, Calif.)
- How to watch: NBC
🏈 Panthers vs. 49ers odds: Monday Night Football
- Kickoff: 8:15 p.m. ET from Levi's Stadium (Santa Clara, Calif.)
- How to watch: ESPN
🔢 NFL Week 12 odds and lines
There's an advantage to betting early NFL odds when attempting to beat the closing line. The closer you wait until kickoff to make your picks, the harder it becomes to identify edges and secure the best price on most sides or totals.
❓ Who's playing on prime time in Week 12?
Week 12 opens with the Bills and Texans clashing on Thursday Night Football. The Buccaneers and Rams are battling on Sunday Night Football, and the week wraps with the Panthers and 49ers on Monday Night Football.
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