NFL Odds Today: Week 12 Lines, Spreads & Totals for Every Game
📊 NFL odds Week 12, 2025
The NFL odds for Week 12 are via bet365.
| Game | Spread | Moneyline | Over/Under |
|---|---|---|---|
| Bills vs. Texans (TNF) | Texans +5.5 | BUF -250 / HOU +205 | 43.5 |
| Colts vs. Chiefs | Chiefs -3 | IND +150 / KC -180 | 50.5 |
| Vikings vs. Packers | Packers -6.5 | MIN +235 / GB -290 | 41.5 |
| Patriots vs. Bengals | Bengals +7 | NE -350 / CIN +275 | 50 |
| Giants vs. Lions | Lions -10.5 | NYG +425 / DET -575 | 50 |
| Jets vs. Ravens | Ravens -13.5 | NYJ +650 / BAL -1000 | 44.5 |
| Steelers vs. Bears | Bears -3 | PIT +135 / CHI -160 | 45 |
| Seahawks vs. Titans | Titans +13 | SEA -850 / TEN +575 | 40.5 |
| Browns vs. Raiders | Raiders -3 | CLE +140 / LV -165 | 37 |
| Jaguars vs. Cardinals | Cardinals +2.5 | JAX -150 / ARI +125 | 47.5 |
| Falcons vs. Saints | Saints +1 | ATL -110 / NO -110 | 38.5 |
| Eagles vs. Cowboys | Cowboys +4.5 | PHI -220 / DAL +180 | 50.5 |
| Buccaneers vs. Rams (SNF) | Rams -6.5 | TB +260 / LA -320 | 49.5 |
| Panthers vs. 49ers (MNF) | 49ers -6.5 | CAR +260 / SF -320 | 48 |
Our NFL picks will be locked and loaded for Week 12, with the Denver Broncos, Miami Dolphins, Los Angeles Chargers, and Washington Commanders.
- The Thursday Night Football odds have the Bills as a 5.5-point road favorite against the Texans in Houston (8:15 p.m. ET, Prime Video)
- Sunday's action wraps with a high-level NFC clash as Rams are spotting the Bucs 6.5 points per the Sunday Night Football odds (8:20 p.m. ET, NBC)
- One game in the Monday Night Football odds as the week wraps up, with the 49ers a 6.5-point home betting favorite against the visiting Panthers (8:15 p.m. ET, ESPN)
Get a jump on next week's action with the Week 13 NFL odds.
📈 Week 12 biggest line movement
🔃 Biggest changes to the Week 12 lines
- The Bills have moved to -5.5 from -2.5 against the Texans, based on a strong showing from the visitors and a poor outing from the Texans
- It also looks like CJ Stroud is unlikely to clear concussion protocol, meaning another week of Davis Mills
- The Cards have flipped from -1 to +2.5 against the Jaguars, while the total jumped from 45.5 to 47.5
- The Cards suffered numerous injuries to their already thinned running back corps, may be without Marvin Harrison Jr., and have QB Kyler Murray on IR
- The Saints are now just +1 underdogs after opening at +3.5 against the visiting Falcons; the total fell from 41.5 to 38.5 points
- Atlanta has lost QB Michael Penix Jr. until at least Week 16 as he was placed on IR today after suffering an injury on Sunday
- The Vikings - Packers dropped from 43.5 to 41.5 following slow showings from both sides
- Minnesota QB JJ McCarthy looked poor for a second straight week, Green Bay QB Jordan Love left briefly but returned while dealing with a shoulder injury
- The Seahawks - Titans dipped from 43.5 to 40.5
- Tennessee again looked a mess on offense, putting up 13 points - the ninth time this season they've scored 20 or fewer point
- Panthers - 49ers on MNF moved from 45.5 to 48
- San Francisco looked efficient as they played one of their healthiest games of the season offense
🏈 Bills vs. Texans odds: Thursday Night Football
- Kickoff: 8:15 p.m. ET from NRG Stadium (Houston)
- How to watch: Prime Video
- Early Bills vs. Texans prediction
🏈 Colts vs. Chiefs: Missouri sports betting nears
- Kickoff: 1 p.m. ET from GEHA Field at Arrowhead Stadium (Kansas City, Mo.)
- How to watch: CBS
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🏈 Buccaneers vs. Rams odds: Sunday Night Football
- Kickoff: 8:20 p.m. ET from SoFi Stadium (Inglewood, Calif.)
- How to watch: NBC
- Early Buccaneers vs. Rams prediction
🏈 Panthers vs. 49ers odds: Monday Night Football
- Kickoff: 8:15 p.m. ET from Levi's Stadium (Santa Clara, Calif.)
- How to watch: ESPN
- Early Panthers vs. 49ers prediction
🔢 NFL Week 12 odds and lines
There's an advantage to betting early NFL odds when attempting to beat the closing line. The closer you wait until kickoff to make your picks, the harder it becomes to identify edges and secure the best price on most sides or totals.
❓ Who's playing on prime time in Week 12?
Week 12 opens with the Bills and Texans clashing on Thursday Night Football. The Buccaneers and Rams are battling on Sunday Night Football, and the week wraps with the Panthers and 49ers on Monday Night Football.
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