NFL Odds This Week: Lines, Spreads & Totals for Every Week 10 Game
📊 NFL odds Week 10, 2025
The NFL odds for Week 10 are via bet365.
| Game | Spread | Moneyline | Over/Under |
|---|---|---|---|
| Raiders vs. Broncos (TNF) | Broncos -9 | LV +375 / DEN -500 | 42 |
| Falcons vs. Colts (Berlin) | Colts -5.5 | ATL +225 / IND -275 | 48.5 |
| Ravens vs. Vikings | Vikings +4 | BAL -210 / MIN +175 | 48 |
| Bills vs. Dolphins | Dolphins +9.5 | BUF -500 / MIA +375 | 50 |
| Browns vs. Jets | Jets -2 | CLE +110 / NYJ -130 | 37 |
| Jaguars vs. Texans | Texans -1 | JAC +100 / HOU -120 | 38 |
| Patriots vs. Buccaneers | Buccaneers -2.5 | NE +120 / TB -140 | 48.5 |
| Saints vs. Panthers | Panthers -5.5 | NO +205 / CAR -250 | 40 |
| Giants vs. Bears | Bears -3.5 | NYG +160 / CHI -190 | 48 |
| Cardinals vs. Seahawks | Seahawks -6.5 | ARI +255 / SEA -315 | 45.5 |
| Lions vs. Commanders | Commanders +8.5 | DET -450 / WAS +350 | 49.5 |
| Rams vs. 49ers | 49ers +3.5 | LAR -185 / SF +155 | 49.5 |
| Steelers vs. Chargers (SNF) | Chargers -3 | PIT +135 / LAC -160 | 45 |
| Eagles vs. Packers (MNF) | Packers -2.5 | PHI +115 / GB -135 | 44.5 |
Our NFL picks will be prepped when the league returns overseas, while the Cincinnati Bengals, Dallas Cowboys, Tennessee Titans, and Kansas City Chiefs are on a bye.
- The Thursday Night Football odds have the Broncos as a 9-point favorite against the Raiders in an AFC West clash (8:15 p.m. ET, Prime Video)
- The Colts are a 5.5-point "home" favorite when they clash with the Falcons in Berlin at 9:30 a.m. ET (NFL Network) on Sunday morning
- Sunday's action wraps with the Steelers and the Chargers in a cross-country Sunday Night Football odds tilt, where Los Angeles is giving up 3 points (8:20 p.m. ET, NBC)
- There's just one game featured in the Monday Night Football odds, with the Packers lined as a 2.5-point favorite against the visiting Eagles (8:15 p.m. ET, ABC/ESPN)
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📈 Week 10 biggest line movement
🔃 Biggest changes to the Week 10 lines
- The Texans shortened from a -3 to -1 favorite over the Jaguars, while the total dropped from 41.5 to 38
- The changes are in direct response to the concussion suffered by Texans QB C.J. Stroud, whose status for Week 10 is unknown
- Panthers lengthened from -3.5 to -5.5 over the visiting Saints
- Carolina picked up a shocking upset victory against Green Bay, while Saints QB Tyler Shough struggled in his first start, earning the hosts a couple more points of respect
- The biggest line move of the week was the Commanders growing from a +3.5 to +8.5 point underdog vs. Lions, while the total dropped from 51.5 to 49.5
- Commanders QB Jayden Daniels suffered a dislocated elbow last week and is headed to the IR
🏈 Raiders vs. Broncos odds: Thursday Night Football
- Kickoff: 8:15 p.m. ET from Empower Field at Mile High (Denver)
- How to watch: Prime Video
- Early Raiders vs. Broncos prediction
🏈 Falcons vs. Colts odds: NFL Germany game
- Kickoff: 9:30 a.m. ET from Olympic Stadium Berlin (Berlin)
- How to watch: NFL Network
- Early Falcons vs. Colts prediction
🏈 Steelers vs. Chargers odds: Sunday Night Football
- Kickoff: 8:20 p.m. ET from SoFi Stadium (Inglewood, Calif.)
- How to watch: NBC
- Early Steelers vs. Chargers prediction
🏈 Eagles vs. Packers odds: Monday Night Football
- Kickoff: 8:15 p.m. ET from Lambeau Field (Green Bay, Wis.)
- How to watch: ESPN/ABC
- Early Eagles vs. Packers prediction
🔢 NFL Week 10 odds and lines
There's an advantage to betting early NFL odds when attempting to beat the closing line. The closer you wait until kickoff to make your NFL picks, the harder it becomes to identify edges and secure the best price on most sides or totals.
❓ Who's playing on prime time in Week 10?
Week 10 opens with the Raiders and Broncos clashing on Thursday Night Football. The league heads to Berlin on Sunday morning for a Germany game with the Colts and the Falcons. The Steelers and Chargers are battling on Sunday Night Football, and the week wraps with the Eagles and Packers on Monday Night Football.
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