NFL Odds Week 1: Lines, Spreads & Totals for Every Game
📊 NFL odds Week 1 2025
The NFL odds for Week 1 are via bet365, as of Sunday morning:
| Game | Spread | Moneyline | Over/Under |
|---|---|---|---|
| Cardinals vs. Saints | Saints +6.5 | Cardinals -290 / Saints +235 | 43.5 (-110/-110) |
| Panthers vs. Jaguars | Jaguars -4 | Panthers +175 / Jaguars -210 | 46.5 (-110/-110) |
| Bengals vs. Browns | Browns +5 | Bengals -245 / Browns +200 | 48 (-110/-110) |
| Raiders vs. Patriots | Patriots -2.5 | Raiders +125 / Patriots -150 | 44 (-110/-110) |
| Dolphins vs. Colts | Colts -1 | Dolphins -110 / Colts -110 | 46.5 (-110/-110) |
| Giants vs. Commanders | Commanders -6 | Giants +225 / Commanders -275 | 45.5 (-110/-110) |
| Steelers vs. Jets | Jets +3 | Steelers -155 / Jets +130 | 37.5 (-110/-110) |
| Buccaneers vs. Falcons | Falcons +1 | Bucs -110 / Falcons -110 | 47 (-110/-110) |
| 49ers vs. Seahawks | Seahawks +1.5 | 49ers -125 / Seahawks +105 | 43.5 (-110/-110) |
| Titans vs. Broncos | Broncos -8.5 | Titans +350 / Broncos -450 | 42.5 (-110/-110) |
| Lions vs. Packers | Packers -1.5 | Lions +105 / Packers -125 | 47.5 (-110/-110) |
| Texans vs. Rams | Rams -3 | Texans +140 / Rams -165 | 43 (-110/-110) |
| Ravens vs. Bills (SNF) | Bills +1 | Ravens -120 / Bills +100 | 50.5 (-110/-110) |
| Vikings vs. Bears (MNF) | Bears +1.5 | Vikings -125 / Bears +105 | 44 (-110/-110) |
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It's finally time. We have our NFL picks loaded up, the opening kickoff of the season is hours away.
Like the first week of any NFL season, we're treated to extra primetime games and so many exciting storylines.
- No. 1 overall draft pick Cam Ward is the only rookie QB to start the season as his Titans (+8.5) visit the Broncos on Sunday (4:05 p.m. ET, FOX)
- The Sunday Night Football odds have the Bills (+1) squaring off with the Ravens in Buffalo at 8:20 p.m. ET (NBC) in a clash of NFL MVP odds contenders
- Longtime Rivals, the Vikings (-1.5) and Bears clash on Monday Night Football (8:15 p.m. ET, ABC/ESPN) to cap the week
Liam Fox's NFL weather report for Week 1 assesses the game-time conditions for the NFL's 12 games in open-air stadiums this week, and how those may influence the Week 1 odds and betting lines. Gary Pearson's NFL live betting guide has you covered for in-game wagers on this week's four prime-time games.
🏈 Ravens vs. Bills odds: Sunday Night Football
- Kickoff: 8:20 p.m. ET from Highmark Stadium (Orchard Park, N.Y.)
- How to watch: NBC
- Ravens vs. Bills prediction: Over 50.5 (-105) via Mike Spector
🏈 Vikings vs. Bears odds: Monday Night Football
- Kickoff: 8:15 p.m. ET from Soldier Field (Chicago)
- How to watch: ABC/ESPN
- Vikings vs. Bears prediction: Under 44.5 (-110) via Gary Pearson
🔢 NFL Week 1 odds and lines
There's an advantage to betting early NFL odds when attempting to beat the closing line. The closer you wait until kickoff to make your NFL picks, the harder it becomes to identify edges and secure the best price on most sides or totals.
💡 NFL expert picks for Week 1
- NFL picks against the spread Week 1
- NFL QB clutch player ratings Week 1
- NFL fantasy pickup player props Week 1
- NFL rookie player props Week 1
- NFL trends that matter Week 1
- NFL weather report Week 1
- NFL survivor picks Week 1
- NFL upset picks Week 1
- NFL betting guide: How to bet Week 1 on a $100 budget
- NFL long-shot parlay Week 1
- NFL live betting guide Week 1
- NFL moneyline picks Week 1
- NFL AI predictions Week 1
- NFL player props Week 1
- NFL Watchability Index Week 1
- NFL expert picks Week 1
- NFL anytime touchdown scorer predictions Week 1
- NFL anytime touchdown scorer parlay Week 1
- NFL best bets Week 1
❓NFL odds FAQs
How do NFL spread odds work?
When betting on the NFL, the favorite needs to win by a certain number of points to cover the "point spread" - also known as the betting line. Conversely, the underdog needs to lose by fewer than the points displayed in the spread or win outright to cash. For example, a 3-point favorite would need to win by more than a field goal to reward bettors.
How do NFL moneyline odds work?
When betting on the NFL, the underdog will have the "longer" odds and is typically priced at "plus-money" odds that indicate the profit on a $100 bet. For example, a team with +150 odds would turn a $100 bet into a $150 profit - or a $10 bet into a $15 profit - according to our odds converter.
Where can I find the NFL betting odds?
Shop around our best NFL betting sites to find the best odds for your college football picks. Our best sports betting sites for all sports include BetMGM, bet365, Caesars, FanDuel, and DraftKings.
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