Seahawks vs. 49ers Predictions & Odds Tonight | Best Bet, TD Pick for NFL Week 18

With the division and a first-round bye on the line, I'm dropping my Seahawks vs. 49ers prediction to get you set for Saturday Night Football.
San Francisco 49ers quarterback Brock Purdy (13) celebrates as we break down our Seahawks vs. 49ers predictions & odds.
Pictured: San Francisco 49ers quarterback Brock Purdy (13) celebrates as we break down our Seahawks vs. 49ers predictions & odds. Photo by Kyle Terada-Imagn Images
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We have the NFC West and a first-round bye on the line in Week 18, and I'm dropping my best Seahawks vs. 49ers prediction to get you set for the 8:00 p.m. ET kickoff tonight at Levi's Stadium (ESPN) as part of our NFL predictions for Week 18.  

The Seahawks are laying 1.5 points on the road in a game that should be tight from wire-to-wire. Can Brock Purdy bury Seattle at home? Let's dive in.


🏈 Seahawks vs. 49ers predictions

See the latest NFL odds and our experts' NFL picks for every game this season.

Predictions Best odds Confidence 
49ers ML +120 via FanDuel ⭐⭐⭐⭐
George Kittle anytime touchdown +160 via FanDuel ⭐⭐⭐

💰 Seahawks vs. 49ers best bet

Search the best NFL player prop odds for any team or player across every market from legal sportsbooks in your area.

49ers moneyline (+120) ⭐⭐⭐⭐

Playoffs start early for the Seahawks and 49ers, who are both looking to not only win the NFC West, but also secure a first-round bye in the playoffs. It's only one of the many Week 18 scenarios we're monitoring entering the final week of the season. 

The 49ers are one of the hottest teams in football after winning six straight, so we can hold the points, as I see them taking this one outright in front of their own fans. Brock Purdy and the offense have been nearly unstoppable over that span, dropping 37 points or more in four of six of those games. Let's watch that offense stay hot on Saturday night.

Score prediction: Seahawks 28, 49ers 31


🙌 Best Seahawks vs. 49ers touchdown scorer pick

See all of our NFL touchdown props and the rest of our NFL betting analysis.

George Kittle, TE, 49ers: TD Pick (+160) ⭐⭐⭐

The Purdy-Kittle connection is alive and well, so let's cash in on it while we can. Over the last two weeks, not only has the tight end scored twice, but his target share has skyrocketed, earning 17 looks from Purdy over that span. The 49ers have truly weaponized him in the red zone, and I'm banking on him scoring one more time in Week 18 with the division (and conference) on the line.


📊 Live Seahawks vs. 49ers odds


📈 Seahawks vs. 49ers betting trends

Seahawks Statistic 49ers
13-3 W-L record 12-4
11-5 ATS record 10-5-1
9-7 O/U record 10-5-1
5.9 Yards per play 5.6
4.6 Yards allowed per play 5.6
-0.3 Turnover margin -0.3
5-0 Last 5 games 5-0
W, 27-10 vs. Panthers Previous result W, 42-38 vs. Bears

🌤️ Seahawks vs. 49ers weather

See our Week 18 weather report for the latest forecast for every Week 18 game.

We're expecting rain for this enormous matchup that will decide both the NFC West and the conference's No. 1 seed. Both teams are equipped to run the football in sloppy conditions, as each has topped 140 rushing yards in back-to-back weeks. We break it all down in detail with our Seahawks vs. 49ers weather report.


📺 How to watch Seahawks vs. 49ers: NFL Week 18

  • Date: Saturday, Jan. 3
  • Kickoff: 8 p.m. ET
  • Location: Levi's Stadium (Santa Clara, Calif.)
  • TV: ABC/ESPN

💡 Seahawks vs. 49ers expert picks


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