Seahawks vs. 49ers Expert Picks | Predictions, Best Bets & Latest Odds Today

If you like meaningful football, you'll love this NFC West rivalry today between the Seattle Seahawks (13-3) and San Francisco 49ers (12-4) with the winner claiming the division title and No. 1 seed in the NFC postseason. Our Seahawks vs. 49ers expert picks compile our expert predictions and best bets ahead of kickoff tonight at 8 p.m. ET as part of our NFL Week 18 predictions.  

🏈 Seahawks vs. 49ers expert picks, predictions & best bets

See the latest NFL odds and our experts' NFL picks for every game this season.

🔮 Seahawks vs. 49ers prediction

49ers moneyline (+120) ⭐⭐⭐⭐

Dustin Saracini: "Playoffs start early for the Seahawks and 49ers, who are both looking to not only win the NFC West, but also secure a first-round bye in the playoffs. It's only one of the many Week 18 scenarios we're monitoring entering the final week of the season. The 49ers are one of the hottest teams in football after winning six straight, so we can hold the points, as I see them taking this one outright in front of their own fans."

See Saracini's full analysis in his Seahawks vs. 49ers predictions, including his favorite player prop bet and the best betting trends, injury report, and more. Our Seahawks vs. 49ers weather report details how rain and wind can impact which team prevails in this NFC West championship matchup.

🔥 Best Seahawks vs. 49ers player prop pick

Jaxon Smith-Njigba Over 7.5 receptions (+114) ⭐⭐⭐⭐

Phil Wood: "When these teams met back in Week 1, Smith-Njigba caught nine passes for 124 yards. He hasn’t let up since, catching at least eight passes in 10 of his 16 games. He’s been targeted at least 12 times in back-to-back games. The 49ers rank 24th in receiving yards allowed, giving up an average of 244.5 per game. They’ve also allowed 378 receptions, third-most in the NFL."

See Wood's full analysis in his Seahawks vs. 49ers player props, including his best bet for Sam Darnold and Jauan Jennings. Both of those players feature in our NFL contract incentives tracker, which details every bonus, milestone, and record at stake in Week 18 and my favorite ways to bet on them.

🙌 Best Seahawks vs. 49ers anytime touchdown scorer pick

🔥 Jaxon Smith-Njigba to score anytime TD (-110) ⭐⭐⭐⭐

Isaiah Sirois: "Jaxon Smith-Njigba paces Seattle in red-zone looks with 17 targets, turning 10 of them into a team-high six touchdowns. He’s also added four more scores from outside the 20. With San Francisco’s defense showing cracks, JSN is in a prime spot to take advantage."

See Sirois' full analysis in his anytime touchdown scorer predictions for Seahawks vs. 49ers, including one bet at +1600 to reach the end zone tonight. You can follow all of our NFL touchdown props for the biggest games every week.

1️⃣ Best Seahawks vs. 49ers first touchdown scorer pick

George Kittle, TE, 49ers (+850) ⭐⭐⭐⭐

LJ Blut: "George Kittle has scored five touchdowns in his last six games played, and has historically had excellent performances against the Seahawks. 49ers quarterback Brock Purdy is coming off his best game of the season in Week 17, and I fully expect him to use Kittle as his main red-zone target in this contest."

See Blut's full analysis in his first touchdown scorer predictions for Seahawks vs. 49ers, including an +1800 long shot to score first tonight in the NFC West title game.

🚀 Seahawks vs. 49ers same-game parlay

Here's a look at what our NFL expert Brenden Schaeffer is betting tonight with his best Seahawks vs. 49ers SGP paying out at +482 odds:

See Schaeffer's full analysis in his Seahawks vs. 49ers same-game parlay, including his analysis for all three SGP bets. You can follow all of our NFL same-game parlay bets for the biggest games every week.

📊 Seahawks vs. 49ers odds

Want more NFL betting advice? Check out all of our NFL analysis and expert predictions for every game from Week 18 through the Super Bowl.

📺 How to watch Seahawks vs. 49ers: NFL Week 18

• Date: Saturday, Jan. 3
• Kickoff: 8 p.m. ET
• Location: Levi's Stadium (Santa Clara, Calif.)
• TV: ABC/ESPN