NFL Picks Against the Spread Today: Expert Week 17 Picks & ATS Predictions
Last Updated: December 28, 2025 9:58 AM EST • 3 minute read X Social Google News Link
Our NFL picks against the spread today have you covered for the 10-game slate as we predict the outcomes of every game.
As part of our NFL predictions for Week 17, we've also got you covered for Monday Night Football. Our record in Weeks 15 and 16 was 18-13, and our overall mark entering Week 17 was 105-100-3.
NFL picks against the spread: Week 17 ATS predictions
See all of our experts' NFL picks for Week 17 based on the latest NFL odds; pick confidence based on a 1-to-5-star scale.
| Matchup | Pick | Confidence |
|---|---|---|
| Cowboys @ Commanders | Cowboys -7 (Push) | ⭐⭐⭐⭐ |
| Lions @ Vikings | Vikings +6 ✅ | ⭐⭐⭐⭐ |
| Broncos @ Chiefs | Broncos -13 ❌ | ⭐⭐⭐⭐⭐ |
| Texans @ Chargers | Chargers -2.5 ❌ | ⭐⭐⭐⭐⭐ |
| Ravens @ Packers | Packers -2.5 ❌ | ⭐⭐⭐ |
| Cardinals @ Bengals | Cardinals +7 | ⭐⭐⭐ |
| Steelers @ Browns | Steelers -4 | ⭐⭐⭐⭐ |
| Saints @ Titans | Saints -2.5 | ⭐⭐⭐⭐⭐ |
| Jaguars @ Colts | Jaguars -6.5 | ⭐⭐⭐⭐ |
| Buccaneers @ Dolphins | Buccaneers -5.5 | ⭐⭐⭐⭐⭐ |
| Patriots @ Jets | Jets +13.5 | ⭐⭐⭐ |
| Seahawks @ Panthers | Panthers +7 | ⭐⭐⭐⭐ |
| Giants @ Raiders | Giants +1.5 | ⭐⭐⭐⭐ |
| Eagles @ Bills | Eagles +2.5 | ⭐⭐⭐⭐ |
| Bears @ 49ers | Bears +3 | ⭐⭐⭐⭐ |
| Rams @ Falcons | Rams -7.5 | ⭐⭐⭐⭐⭐ |
My best ATS picks for Week 17
Broncos (-13) vs. Chiefs ⭐⭐⭐⭐⭐
Nothing says "Merry Christmas" like watching the Broncos beat up on the Chiefs, who are just in a terrible spot right now. Not only is Patrick Mahomes lost for the season, but as is backup quarterback Gardner Minshew. This team just lost to the lowly Titans 26-9 - it's all a new feeling for this franchise (and its fans), who have found nothing but success ever since Mahomes entered the league. With third-string quarterback Chris Oladokun leading the 6-9 offense, I expect the vaunted Broncos defense to eat him alive, and for Bo Nix to do the rest.
Sorry, Chiefs fans, you're getting a bunch of coal under the Christmas tree this year.
Chargers (-2.5) vs. Texans ⭐⭐⭐⭐⭐
Is C.J. Stroud just a bad quarterback? I'm starting to lean that way, at least. He missed five wide-open receivers as the Texans squeaked out a victory against the worst team in the NFL in the Raiders. He'll get a tough opponent in Week 17, as the Chargers own the sixth-ranked pass defense, allowing just 179 yards per game through the air. On the other side, this Texans defense will be able to keep it close while going against the worst offensive line in the game, according to Pro Football Focus. In the end, expect Justin Herbert's unit to win by a field goal.
Eagles (+2.5) vs. Bills ⭐⭐⭐⭐⭐
Outside of James Cook, the Bills' offense was almost non-existent against the Browns in Week 16. I still don't understand why Brandon Beane didn't go out and get some wide receiver help at the deadline, but I digress. In a game that will likely come down to one score, I'll take the points every single time. I'm looking forward to watching Jalen Hurts and Josh Allen go head-to-head on Sunday, and I'm giving Philly the benefit of the doubt against a Bills defense that can be exposed.
Our Mike Spector also backs Philly in his NFL upset picks.
💡 More Week 17 predictions
Want more NFL betting advice? Check out all of our NFL analysis and expert predictions for every game in Week 17.
💡 NFL expert picks for Week 17
Want more NFL betting advice? Check out all of our NFL analysis and expert predictions for every game this season.
- NFL picks against the spread Week 17
- NFL AI predictions Week 17
- NFL upset picks Week 17
- NFL weather report Week 17
- NFL player props Week 17
- NFL best bets Week 17
- NFL anytime touchdown scorer predictions Week 17
- NFL first touchdown scorer predictions Week 17
- NFL 2+ touchdown scorer predictions Week 17
- NFL anytime touchdown scorer parlay Week 17
📃 Affiliate disclosure
Sportsbook Review may receive a commission if you sign up through our links. Not intended for use in MA. Bonuses not applicable in Ontario. 21+ only. (Gambling problem? Call 1-800-GAMBLER)
Dustin Saracini X social