Monday Night Football Player Prop Picks, Predictions Week 16: Will Chargers' Playoff Push Continue?

Check out our best Monday Night Football player prop picks for the Colts-Chargers Week 16 matchup based on the top odds.

Rodrigo Villagomez

Last Updated: December 26, 2022 10:21 AM EST • 3 minute read

The Los Angeles Chargers look to improve their postseason chances against the Indianapolis Colts to close out Week 16. Here are our Monday Night Football player prop picks based on the latest odds.

A thrilling holiday weekend comes to an end on Monday night as the Los Angeles Chargers travel to Indiana to take on the Indianapolis Colts. The Chargers' hopes were high to start the season, but now they're fighting to stay in the playoff mix.

Meanwhile, the Colts have been suffering through a disappointing campaign and are starting their third quarterback. They'll try to play spoiler over the last few weeks of the season.

Here are our best Chargers-Colts Monday Night Football player prop picks for Week 16 (odds via FanDuel Sportsbook, DraftKings Sportsbook, and BetMGM; Pick confidence is based on a 1-to-5-star scale).

Check out our Chargers vs. Colts game picks, Justin Herbert prop picks, and Colts-Chargers SGP.

Monday Night Football Player Prop Picks for Week 16

Mike Williams Over Michael Pittman Jr. receiving yards (+100 via DraftKings) ⭐⭐⭐⭐
Total touchdowns Under 4.5 (+120 via BetMGM) ⭐⭐⭐⭐
Derwin James to record a sack, and Chargers win (+1000 via FanDuel) ⭐⭐⭐⭐

Chargers vs. Colts Odds

Monday Night Football Prop Predictions

Williams Over Pittman Jr. receiving yards (+100) ⭐⭐⭐⭐

Williams comes into Monday night averaging 69.3 receiving yards per game over his 10 appearances in 2022-23. However, it's been feast or famine for him. He's posted four games with over 100 yards, but also four with fewer than 20. The Colts' defense surrendered 157 yards to K.J. Osborn and 123 to Justin Jefferson of the Minnesota Vikings in Week 15.

Pittman Jr. is averaging 62.7 yards per game during his 13 contests in 2022-23. His production has remained somewhat consistent despite the team's turmoil at quarterback. However, his 7.6 yards per reception over Pittman's last three games doesn't lead to much confidence.

Journeyman Nick Foles is under center for the Colts in Week 16. The offense will encounter a Los Angeles defense that allowed just 32 yards to Tennessee Titans wide receivers in Week 15.

Total touchdowns Under 4.5 (+120) ⭐⭐⭐⭐

Despite boasting a star-studded offensive lineup, the Chargers only average 2.4 touchdowns per game. They've registered exactly two touchdowns over their last three matchups. Los Angeles has managed 2.6 touchdowns per contest on the road. Meanwhile, the Colts are allowing 2.5 touchdowns per game at home.

Indianapolis is averaging the second-fewest touchdowns per game in 2022-23 while crossing the goal line 1.6 times. The Colts tallied two touchdowns in two of their last three battles. They'll be attempting to score against a Chargers defense that's surrendered 2.3 touchdowns over its last three games.

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James to record a sack and Chargers win (+1000) ⭐⭐⭐⭐

James has returned to practice this week, and all signs point to him playing Monday night. The Chargers aren't afraid to send their star safety after the opposing quarterback, and James has recorded four sacks on the season as a result. Los Angeles has registered six sacks over the past two weeks, including four in Week 15 against the Titans.

The defensive back gets a more than favorable matchup on Monday against a Colts offensive line allowing the second most sacks per game. Indianapolis is giving up 3.5 sacks per matchup in 2022-23. Opposing teams have combined to notch 23 sacks over Indy's last six outings.

Monday Night Football player prop picks made 12/26/2022 at 2:12 p.m. ET.

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Written by:
Rodrigo Villagomez

Rod has been a contributing author at Sportsbook Review for the last two years specializing in NASCAR and NFL prop betting. He has been writing and podcasting professionally for almost 20 years, spending the last four years in the sports gambling space. Rod has made several appearances on the SiriusXM Fantasy Sports channel. He’s appeared multiple times on the Fantasy Alarm Show with Howard Bender as well as several times over the last two years during the FSGA Draft Week. He is a published author in the academic world with an article on steroids in baseball featured in the Bedford Reader textbook. Rod loves to find non-traditional bets which has led him to dive into the world of defensive and kicking props in football among others. His love of motorsports has translated into several winning weeks of both NASCAR and Formula 1 bets. Rod is a fan first and aims to provide betting picks that are not only profitable but will provide the maximum entertainment value during the sweat. Ultimately, he tries to remember that watching sports should still be fun and anything else is icing on the cake.