Bills vs. Jaguars Expert Picks for Wild Card Weekend: NFL Predictions, Best Bets & Odds
The AFC bracket gets rolling today when the Jacksonville Jaguars (13-4) host the Buffalo Bills (12-5) at EverBank Stadium at 1 p.m. ET (ESPN), with Jacksonville as the -1.5 betting odds favorite.
Our Bills vs. Jaguars expert picks for NFL Wild Card Weekend are diving in on the matchup while highlighting our best NFL playoff predictions.
🏈 Bills vs. Jaguars expert picks: NFL Wild Card Weekend predictions
See the latest NFL odds and our experts' NFL picks for every game this season.
| Betting expert | Best bet | Best odds | Confidence |
|---|---|---|---|
| Dustin Saracini | Jaguars ML | -108 via FanDuel | ⭐⭐⭐⭐⭐ |
| Dustin Saracini | Trevor Lawrence anytime TD | +175 via FanDuel | ⭐⭐⭐⭐⭐ |
| Corey Scott | Josh Allen anytime TD | -125 via DraftKings | ⭐⭐⭐⭐⭐ |
| Brenden Schaeffer | Over 51.5 | -112 via DraftKings | ⭐⭐⭐⭐ |
| Brenden Schaeffer | Ty Johnson Over 1.5 receptions | -118 via DraftKings | ⭐⭐⭐⭐ |
🔮 Bills vs. Jaguars prediction
Jaguars ML (-108) ⭐⭐⭐⭐⭐
Dustin Saracini: The Jaguars are one of the most complete teams in the league, boasting a top-10 pass defense alongside the league's best run-stopping unit. Trevor Lawrence surged up the NFL MVP odds board down the stretch and is playing the best football of his career. It's a different feeling in Jacksonville this year, leading me to believe they might make a deep run.
See Dustin Saracini's full analysis in his Bills vs. Jaguars prediction, including his favorite player prop bet and the best Bills vs. Jaguars betting trends, injury report, and more.
🔥 Best Bills vs. Jaguars player prop pick
Trevor Lawrence anytime touchdown (+175) ⭐⭐⭐⭐⭐
Dustin Saracini: Lawrence was a certified menace down the stretch, racking up four rushing touchdowns in the final four games of the season. With more than five carries per game during that run, it wouldn’t be a surprise to see him find the end zone again - especially against a Bills defense that lets opponents score nearly 60% of the time once they reach the red zone, a mark that sits firmly in the bottom 10 league-wide.
See Saracini's full analysis in his Bills vs. Jaguars player props, including his best bet for Josh Allen and James Cook tonight.
🙌 Best Bills vs. Jaguars anytime touchdown scorer pick
Josh Allen, QB, Bills (-125) ⭐⭐⭐⭐⭐
Corey Scott: Excluding Week 18, when he played only one snap, Allen rushed for 14 touchdowns in 16 regular-season games. He rushed for two touchdowns in a one-point loss to the Philadelphia Eagles in Week 17, and this game is expected to be close too.
See Corey Scott's full analysis in his anytime touchdown scorer predictions for the Bills-Jaguars Wild Card Weekend matchups. You can follow all of our NFL touchdown props for the biggest games every week.
🚀 Bills vs. Jaguars same-game parlay
Here's a look at what our NFL expert Brenden Schaeffer is betting today with his best Bills vs. Jaguars SGP paying out at +650 odds:
💵 Bills vs. Jaguars SGP bets
- Over 51.5 (-112) ⭐⭐⭐⭐
- Trevor Lawrence anytime TD scorer (+180) ⭐⭐⭐⭐
- Ty Johnson Over 1.5 receptions (-118) ⭐⭐⭐⭐
Best SGP odds: +650 via DraftKings ($10 to win $65)
See Brenden Schaeffer's full analysis in his Bills vs. Jaguars same-game parlay, including his analysis for all three SGP bets.
📊 Bills vs. Jaguars odds: NFL Wild Card Weekend
Want more NFL betting advice? Check out all of our NFL analysis and expert predictions for every game this season.
📺 How to watch Bills vs. Jaguars: NFL Wild Card Weekend
- Date: Sunday, Jan. 11, 2026
- Kickoff: 1 p.m. ET
- Location: EverBank Stadium (Jacksonville, FL.)
- TV: ESPN
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